The TRAR gene classifier to predict response to neoadjuvant therapy in HER2-positive and ER-positive breast cancer patients: an explorative analysis from the NeoSphere trial.

As most erb-b2 receptor tyrosine kinase 2 (HER2)-positive breast cancer (BC) patients currently receive dual HER2-targeting added to neoadjuvant chemotherapy, improved methods for identifying individual response, and assisting postsurgical salvage therapy, are needed. Herein, we evaluated the 41-gen...

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Detalles Bibliográficos
Autores: Triulzi, Tiziana, Bianchini, Giampaolo, Di Cosimo, Serena, Pienkowski, Tadeusz, Im, Young-Hyuck, Valeria Bianchi, Giulia, Galbardi, Barbara, Dugo, Matteo, De Cecco, Loris, Tseng, Ling-Ming, Liu, Mei-Ching, Bermejo, Begona, Semiglazov, Vladimir, Viale, Giulia, de la Haba-Rodriguez, Juan, Oh, Do-Youn, Poirier, Brigitte, Valagussa, Pinuccia, Gianni, Luca, Tagliabue, Elda
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p16334
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/16334
Access Level:acceso abierto
Palabra clave:HER2
breast cancer
gene expression profile
pertuzumab
predictive biomarker
trastuzumab
Descripción
Sumario:As most erb-b2 receptor tyrosine kinase 2 (HER2)-positive breast cancer (BC) patients currently receive dual HER2-targeting added to neoadjuvant chemotherapy, improved methods for identifying individual response, and assisting postsurgical salvage therapy, are needed. Herein, we evaluated the 41-gene classifier trastuzumab advantage risk model (TRAR) as a predictive marker for patients enrolled in the NeoSphere trial. TRAR scores were computed from RNA of 350 pre- and 166 post-treatment tumor specimens. Overall, TRAR score was significantly associated with pathological complete response (pCR) rate independently of other predictive clinico-pathological variables. Separate analyses according to estrogen receptor (ER) status showed a significant association between TRAR score and pCR in ER-positive specimens but not in ER-negative counterparts. Among ER-positive BC patients not achieving a pCR, those with TRAR-low scores in surgical specimens showed a trend for lower distant event-free survival. In conclusion, in HER2-positive/ER-positive BC, TRAR is an independent predictor of pCR and represents a promising tool to select patients responsive to anti-HER2-based neoadjuvant therapy and to assist treatment escalation and de-escalation strategies in this setting.

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