Routine cerebrospinal fluid parameters as biomarkers in first-episode psychosis: A prospective observational study

In recent years, multiple studies have investigated the role of biomarkers in first-episode psychosis (FEP) to facilitate early diagnosis, disease stratification, therapeutic choice and outcome prediction. Few studies have focused on cerebrospinal fluid (CSF) investigations. In this prospective obse...

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Autores: Giné-Servén, Eloi, Martinez-Ramirez, Maria, Boix-Quintana, Ester, Davi-Loscos, Eva, Guanyabens, Nicolau, Casado, Virginia, Crespo Facorro, Benedicto, Labad, Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/138693
Acceso en línea:https://hdl.handle.net/11441/138693
https://doi.org/10.1016/j.pnpbp.2021.110424
Access Level:acceso abierto
Palabra clave:Biomarkers
First episode
Psychosis
Protein
LDH
CSF
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spelling Routine cerebrospinal fluid parameters as biomarkers in first-episode psychosis: A prospective observational studyGiné-Servén, EloiMartinez-Ramirez, MariaBoix-Quintana, EsterDavi-Loscos, EvaGuanyabens, NicolauCasado, VirginiaCrespo Facorro, BenedictoLabad, JavierBiomarkersFirst episodePsychosisProteinLDHCSFIn recent years, multiple studies have investigated the role of biomarkers in first-episode psychosis (FEP) to facilitate early diagnosis, disease stratification, therapeutic choice and outcome prediction. Few studies have focused on cerebrospinal fluid (CSF) investigations. In this prospective observational study, 95 FEP inpatients were followed up for one year. A lumbar puncture was performed at index admission (baseline) to study the CSF parameters (glucose, total proteins, lactate dehydrogenase [LDH], and pleocytosis). At the baseline visit, the clinical assessment included prodromal (psychotic and non-psychotic) symptoms before the psychotic outbreak and psychopathology at admission. The SCID-I was administered to obtain a clinical diagnosis at baseline and at 12 months. The relationship between prodromal and psychopathology symptoms at the baseline visit was tested with multiple linear regression. Multinomial logistic regression was also used to explore the association between CSF biomarkers and longitudinal diagnoses at follow-up (schizophrenia/schizoaffective disorder vs unipolar/bipolar depression vs other psychoses). Higher CSF glucose was associated with depressive (Standardized beta = 0.27, p = 0.041) and disorganized/concrete symptoms (Standardized beta = 0.33, p = 0.023) and lower CSF LDH was associated with prodromal symptoms (Standardized beta = −0.25, p = 0.042). Lower LDH concentrations were also associated with social withdrawal (r = −0.342, p = 0.001). CSF glucose was a predictor of the long-term diagnosis (lower CSF concentrations were associated with schizophrenia or schizoaffective disorder diagnoses [OR = 0.88, CI95%: 0.77–0.99). Our study suggests that CSF biomarkers that involve bioenergetic systems are associated with prodromal symptoms and the phenotype of psychotic disorders during the early stages of the disease.Pergamon Elsevier Science LTDPsiquiatríaCTS1086: Psiquiatría Traslacional2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/138693https://doi.org/10.1016/j.pnpbp.2021.110424reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésProgress in Neuro-Psychopharmacology and Biological Psychiatry, 112.http://doi.org/10.1016/j.pnpbp.2021.110424info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1386932026-06-17T12:51:07Z
dc.title.none.fl_str_mv Routine cerebrospinal fluid parameters as biomarkers in first-episode psychosis: A prospective observational study
title Routine cerebrospinal fluid parameters as biomarkers in first-episode psychosis: A prospective observational study
spellingShingle Routine cerebrospinal fluid parameters as biomarkers in first-episode psychosis: A prospective observational study
Giné-Servén, Eloi
Biomarkers
First episode
Psychosis
Protein
LDH
CSF
title_short Routine cerebrospinal fluid parameters as biomarkers in first-episode psychosis: A prospective observational study
title_full Routine cerebrospinal fluid parameters as biomarkers in first-episode psychosis: A prospective observational study
title_fullStr Routine cerebrospinal fluid parameters as biomarkers in first-episode psychosis: A prospective observational study
title_full_unstemmed Routine cerebrospinal fluid parameters as biomarkers in first-episode psychosis: A prospective observational study
title_sort Routine cerebrospinal fluid parameters as biomarkers in first-episode psychosis: A prospective observational study
dc.creator.none.fl_str_mv Giné-Servén, Eloi
Martinez-Ramirez, Maria
Boix-Quintana, Ester
Davi-Loscos, Eva
Guanyabens, Nicolau
Casado, Virginia
Crespo Facorro, Benedicto
Labad, Javier
author Giné-Servén, Eloi
author_facet Giné-Servén, Eloi
Martinez-Ramirez, Maria
Boix-Quintana, Ester
Davi-Loscos, Eva
Guanyabens, Nicolau
Casado, Virginia
Crespo Facorro, Benedicto
Labad, Javier
author_role author
author2 Martinez-Ramirez, Maria
Boix-Quintana, Ester
Davi-Loscos, Eva
Guanyabens, Nicolau
Casado, Virginia
Crespo Facorro, Benedicto
Labad, Javier
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Psiquiatría
CTS1086: Psiquiatría Traslacional
dc.subject.none.fl_str_mv Biomarkers
First episode
Psychosis
Protein
LDH
CSF
topic Biomarkers
First episode
Psychosis
Protein
LDH
CSF
description In recent years, multiple studies have investigated the role of biomarkers in first-episode psychosis (FEP) to facilitate early diagnosis, disease stratification, therapeutic choice and outcome prediction. Few studies have focused on cerebrospinal fluid (CSF) investigations. In this prospective observational study, 95 FEP inpatients were followed up for one year. A lumbar puncture was performed at index admission (baseline) to study the CSF parameters (glucose, total proteins, lactate dehydrogenase [LDH], and pleocytosis). At the baseline visit, the clinical assessment included prodromal (psychotic and non-psychotic) symptoms before the psychotic outbreak and psychopathology at admission. The SCID-I was administered to obtain a clinical diagnosis at baseline and at 12 months. The relationship between prodromal and psychopathology symptoms at the baseline visit was tested with multiple linear regression. Multinomial logistic regression was also used to explore the association between CSF biomarkers and longitudinal diagnoses at follow-up (schizophrenia/schizoaffective disorder vs unipolar/bipolar depression vs other psychoses). Higher CSF glucose was associated with depressive (Standardized beta = 0.27, p = 0.041) and disorganized/concrete symptoms (Standardized beta = 0.33, p = 0.023) and lower CSF LDH was associated with prodromal symptoms (Standardized beta = −0.25, p = 0.042). Lower LDH concentrations were also associated with social withdrawal (r = −0.342, p = 0.001). CSF glucose was a predictor of the long-term diagnosis (lower CSF concentrations were associated with schizophrenia or schizoaffective disorder diagnoses [OR = 0.88, CI95%: 0.77–0.99). Our study suggests that CSF biomarkers that involve bioenergetic systems are associated with prodromal symptoms and the phenotype of psychotic disorders during the early stages of the disease.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/138693
https://doi.org/10.1016/j.pnpbp.2021.110424
url https://hdl.handle.net/11441/138693
https://doi.org/10.1016/j.pnpbp.2021.110424
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Progress in Neuro-Psychopharmacology and Biological Psychiatry, 112.
http://doi.org/10.1016/j.pnpbp.2021.110424
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon Elsevier Science LTD
publisher.none.fl_str_mv Pergamon Elsevier Science LTD
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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