Development of small tissue engineered blood vessels and their clinical and research applications
Since the first tissue engineered blood vessel (TEBV) was developed, different approaches, biomaterial scaffolds and cell sources have been used to obtain an engineered vessel as much similar as native vessels in terms of structure, functionality and mechanical properties. At the same time, diverse...
| Autores: | , , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:20.500.12328/5163 |
| Acesso em linha: | http://hdl.handle.net/20.500.12328/5163 https://dx.doi.org/10.1088/1758-5090/add626 |
| Access Level: | acceso abierto |
| Palavra-chave: | Tissue engineered blood vessels Tissue engineering Vascular engineering Vascular model disease Vascular substitutes Vascularization Vasos sanguíneos creados mediante ingeniería tisular Ingeniería tisular Ingeniería vascular Enfermedad vascular modelo Sustitutos vasculares Vascularización Vasos sanguinis creats mitjançant enginyeria tissular Enginyeria tissular Enginyeria vascular Malaltia vascular model Substituts vasculars Vascularització 57 |
| Resumo: | Since the first tissue engineered blood vessel (TEBV) was developed, different approaches, biomaterial scaffolds and cell sources have been used to obtain an engineered vessel as much similar as native vessels in terms of structure, functionality and mechanical properties. At the same time, diverse needs to obtain a functional TEBV have emerged, such as for blood vessel replacement for cardiovascular diseases (CVDs) to be used as artery bypass, to vascularize tissue engineered constructs, or even to model vascular diseases or drug testing. In this review, after briefly describing the native structure and function of arteries, we will give an overview of different biomaterials, cells and methods that have been used during the last years for the development of small TEBV (1-6 mm diameter). The importance of perfusing the TEBV to acquire functionality and maturation will be also discussed. Finally, we will center the review on TEBV applications beyond their use as vascular graft for CVDs. |
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