Potent virucidal activity in vitro of photodynamic therapy with Hpericum extract as photosensitizer and white light against human coronavirus HCoV-229E

The emergent human coronavirus SARS-CoV-2 and its high infectivity rate has highlighted the strong need for new virucidal treatments. In this sense, the use of photodynamic therapy (PDT) with white light, to take advantage of the sunlight, is a potent strategy for decreasing the virulence and pathog...

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Detalles Bibliográficos
Autores: Praena García, Beatriz, Mascaraque Checa, Marta, Andreu, Sabina, Bello-Morales Arroyo, Ángeles Raquel, Abarca-Lachen, Edgar, Rapozzi, Valentina, Gilaberte, Yolanda, González, Salvador, López Guerrero, José Antonio, Juarranz de la Fuente, Ángeles
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/707173
Acceso en línea:http://hdl.handle.net/10486/707173
https://dx.doi.org/10.3390/pharmaceutics14112364
Access Level:acceso abierto
Palabra clave:Animal Cell
Huh-7 Cell Line
Virucidal Activity
White Light
Biología y Biomedicina / Biología
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spelling Potent virucidal activity in vitro of photodynamic therapy with Hpericum extract as photosensitizer and white light against human coronavirus HCoV-229EPraena García, BeatrizMascaraque Checa, MartaAndreu, SabinaBello-Morales Arroyo, Ángeles RaquelAbarca-Lachen, EdgarRapozzi, ValentinaGilaberte, YolandaGonzález, SalvadorLópez Guerrero, José AntonioJuarranz de la Fuente, ÁngelesAnimal CellHuh-7 Cell LineVirucidal ActivityWhite LightBiología y Biomedicina / BiologíaThe emergent human coronavirus SARS-CoV-2 and its high infectivity rate has highlighted the strong need for new virucidal treatments. In this sense, the use of photodynamic therapy (PDT) with white light, to take advantage of the sunlight, is a potent strategy for decreasing the virulence and pathogenicity of the virus. Here, we report the virucidal effect of PDT based on Hypericum extract (HE) in combination with white light, which exhibits an inhibitory activity of the human coronavirus HCoV-229E on hepatocarcinoma Huh-7 cells. Moreover, despite continuous exposure to white light, HE has long durability, being able to maintain the prevention of viral infection. Given its potent in vitro virucidal capacity, we propose HE in combination with white light as a promising candidate to fight against SARS-CoV-2 as a virucidal compoundThis research was funded by Fundación Universidad Autónoma de Madrid, grant number PI21/00315 and by Instituto de Salud Carlos III, grant number PI21/00953. Institutional Review Board Statement: Not applicableMDPIDepartamento de Biología MolecularDepartamento de BiologíaFacultad de Ciencias20222022-11-02research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/707173https://dx.doi.org/10.3390/pharmaceutics14112364reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7071732026-06-23T12:46:27Z
dc.title.none.fl_str_mv Potent virucidal activity in vitro of photodynamic therapy with Hpericum extract as photosensitizer and white light against human coronavirus HCoV-229E
title Potent virucidal activity in vitro of photodynamic therapy with Hpericum extract as photosensitizer and white light against human coronavirus HCoV-229E
spellingShingle Potent virucidal activity in vitro of photodynamic therapy with Hpericum extract as photosensitizer and white light against human coronavirus HCoV-229E
Praena García, Beatriz
Animal Cell
Huh-7 Cell Line
Virucidal Activity
White Light
Biología y Biomedicina / Biología
title_short Potent virucidal activity in vitro of photodynamic therapy with Hpericum extract as photosensitizer and white light against human coronavirus HCoV-229E
title_full Potent virucidal activity in vitro of photodynamic therapy with Hpericum extract as photosensitizer and white light against human coronavirus HCoV-229E
title_fullStr Potent virucidal activity in vitro of photodynamic therapy with Hpericum extract as photosensitizer and white light against human coronavirus HCoV-229E
title_full_unstemmed Potent virucidal activity in vitro of photodynamic therapy with Hpericum extract as photosensitizer and white light against human coronavirus HCoV-229E
title_sort Potent virucidal activity in vitro of photodynamic therapy with Hpericum extract as photosensitizer and white light against human coronavirus HCoV-229E
dc.creator.none.fl_str_mv Praena García, Beatriz
Mascaraque Checa, Marta
Andreu, Sabina
Bello-Morales Arroyo, Ángeles Raquel
Abarca-Lachen, Edgar
Rapozzi, Valentina
Gilaberte, Yolanda
González, Salvador
López Guerrero, José Antonio
Juarranz de la Fuente, Ángeles
author Praena García, Beatriz
author_facet Praena García, Beatriz
Mascaraque Checa, Marta
Andreu, Sabina
Bello-Morales Arroyo, Ángeles Raquel
Abarca-Lachen, Edgar
Rapozzi, Valentina
Gilaberte, Yolanda
González, Salvador
López Guerrero, José Antonio
Juarranz de la Fuente, Ángeles
author_role author
author2 Mascaraque Checa, Marta
Andreu, Sabina
Bello-Morales Arroyo, Ángeles Raquel
Abarca-Lachen, Edgar
Rapozzi, Valentina
Gilaberte, Yolanda
González, Salvador
López Guerrero, José Antonio
Juarranz de la Fuente, Ángeles
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Biología Molecular
Departamento de Biología
Facultad de Ciencias
dc.subject.none.fl_str_mv Animal Cell
Huh-7 Cell Line
Virucidal Activity
White Light
Biología y Biomedicina / Biología
topic Animal Cell
Huh-7 Cell Line
Virucidal Activity
White Light
Biología y Biomedicina / Biología
description The emergent human coronavirus SARS-CoV-2 and its high infectivity rate has highlighted the strong need for new virucidal treatments. In this sense, the use of photodynamic therapy (PDT) with white light, to take advantage of the sunlight, is a potent strategy for decreasing the virulence and pathogenicity of the virus. Here, we report the virucidal effect of PDT based on Hypericum extract (HE) in combination with white light, which exhibits an inhibitory activity of the human coronavirus HCoV-229E on hepatocarcinoma Huh-7 cells. Moreover, despite continuous exposure to white light, HE has long durability, being able to maintain the prevention of viral infection. Given its potent in vitro virucidal capacity, we propose HE in combination with white light as a promising candidate to fight against SARS-CoV-2 as a virucidal compound
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-11-02
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/707173
https://dx.doi.org/10.3390/pharmaceutics14112364
url http://hdl.handle.net/10486/707173
https://dx.doi.org/10.3390/pharmaceutics14112364
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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