Regulation of Male Fertility by the Renin-Angiotensin System

The renin-angiotensin system (RAS) is a peptidic system known mainly for its roles in the maintenance of blood pressure and electrolyte and fluid homeostasis. However, several tissues and cells have been described to possess an intrinsic RAS that acts locally through different paracrine and autocrin...

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Authors: Gianzo Citores, Marta, Subirán Ciudad, Nerea
Format: article
Publication Date:2020
Country:España
Institution:Universidad del País Vasco
Repository:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/48215
Online Access:http://hdl.handle.net/10810/48215
Access Level:Open access
Keyword:renin-angiotensin system
male infertility
angiotensin
renin
testis
spermatozoa
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spelling Regulation of Male Fertility by the Renin-Angiotensin SystemGianzo Citores, MartaSubirán Ciudad, Nerearenin-angiotensin systemmale infertilityangiotensinrenintestisspermatozoaThe renin-angiotensin system (RAS) is a peptidic system known mainly for its roles in the maintenance of blood pressure and electrolyte and fluid homeostasis. However, several tissues and cells have been described to possess an intrinsic RAS that acts locally through different paracrine and autocrine mechanisms. In the male reproductive system, several components of this system have been observed in various organs and tissues, such as the testes, spermatozoa and seminal fluid. Some functions attributed to this local RAS are maintenance of seminal plasma electrolytes, regulation of steroidogenesis and spermatogenesis, and sperm functions. However, their specific actions in these locations are not fully understood. Therefore, a deep knowledge of the functions of the RAS at both the testicular and seminal levels could clarify its roles in male infertility and sperm physiology, and the different RAS elements could be used to design tools enabling the diagnosis and/or treatment of male infertility.This study was supported by grants from the Basque Government (GIC12/173) and University of the Basque Country (UPV/EHU) (EHUA14/17).MDPI2020202020202020info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/48215reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.mdpi.com/1422-0067/21/21/7943/htminfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).oai:addi.ehu.eus:10810/482152026-06-18T09:23:17Z
dc.title.none.fl_str_mv Regulation of Male Fertility by the Renin-Angiotensin System
title Regulation of Male Fertility by the Renin-Angiotensin System
spellingShingle Regulation of Male Fertility by the Renin-Angiotensin System
Gianzo Citores, Marta
renin-angiotensin system
male infertility
angiotensin
renin
testis
spermatozoa
title_short Regulation of Male Fertility by the Renin-Angiotensin System
title_full Regulation of Male Fertility by the Renin-Angiotensin System
title_fullStr Regulation of Male Fertility by the Renin-Angiotensin System
title_full_unstemmed Regulation of Male Fertility by the Renin-Angiotensin System
title_sort Regulation of Male Fertility by the Renin-Angiotensin System
dc.creator.none.fl_str_mv Gianzo Citores, Marta
Subirán Ciudad, Nerea
author Gianzo Citores, Marta
author_facet Gianzo Citores, Marta
Subirán Ciudad, Nerea
author_role author
author2 Subirán Ciudad, Nerea
author2_role author
dc.subject.none.fl_str_mv renin-angiotensin system
male infertility
angiotensin
renin
testis
spermatozoa
topic renin-angiotensin system
male infertility
angiotensin
renin
testis
spermatozoa
description The renin-angiotensin system (RAS) is a peptidic system known mainly for its roles in the maintenance of blood pressure and electrolyte and fluid homeostasis. However, several tissues and cells have been described to possess an intrinsic RAS that acts locally through different paracrine and autocrine mechanisms. In the male reproductive system, several components of this system have been observed in various organs and tissues, such as the testes, spermatozoa and seminal fluid. Some functions attributed to this local RAS are maintenance of seminal plasma electrolytes, regulation of steroidogenesis and spermatogenesis, and sperm functions. However, their specific actions in these locations are not fully understood. Therefore, a deep knowledge of the functions of the RAS at both the testicular and seminal levels could clarify its roles in male infertility and sperm physiology, and the different RAS elements could be used to design tools enabling the diagnosis and/or treatment of male infertility.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/48215
url http://hdl.handle.net/10810/48215
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/1422-0067/21/21/7943/htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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