Inference of natural selection from ancient DNA
Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. Sequencing ancient DNA from temporally spaced...
| Autores: | , , , , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/52946 |
| Acesso em linha: | http://hdl.handle.net/10230/52946 http://dx.doi.org/10.1002/evl3.165 |
| Access Level: | acceso abierto |
| Palavra-chave: | Adaptació (Biologia) ADN antic Selecció natural Genòmica |
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Inference of natural selection from ancient DNADehasque, MarianneÁvila Arcos, María C.Díez-Del-Molino, DavidFumagalli, MatteoGuschanski, KaterinaLorenzen, Eline D.Malaspinas, Anna-SapfoMarquès i Bonet, Tomàs, 1975-Martin, Michael D.Murray, Gemma G. R.Papadopulos, Alexander S. T.Overgaard Therkildsen, NinaWegmann, DanielDalén, LoveFoote, Andrew D.Adaptació (Biologia)ADN anticSelecció naturalGenòmicaEvolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. Sequencing ancient DNA from temporally spaced samples can inform about past selection processes, as time series data allow direct quantification of population parameters collected before, during, and after genetic changes driven by selection. In this Comment and Opinion, we advocate for the inclusion of temporal sampling and the generation of paleogenomic datasets in evolutionary biology, and highlight some of the recent advances that have yet to be broadly applied by evolutionary biologists. In doing so, we consider the expected signatures of balancing, purifying, and positive selection in time series data, and detail how this can advance our understanding of the chronology and tempo of genomic change driven by selection. However, we also recognize the limitations of such data, which can suffer from postmortem damage, fragmentation, low coverage, and typically low sample size. We therefore highlight the many assumptions and considerations associated with analyzing paleogenomic data and the assumptions associated with analytical methods.This work resulted from a synthesis and writing retreat as part of ADAPT (Ancient DNA studies of Adaptive Processes through Time) Special Topic Network generously funded by the European Society for Evolutionary Biology (ESEB). ADF was supported by European Union's Horizon 2020 research and innovation program under the Marie Skłodowska‐Curie grant agreement No. 663830. ASM was supported by a European Research Council (ERC) grant. LD and MD acknowledge fudning from the Swedish Research Coucil (VR grant 2017‐04647)Wiley Open Access202220222020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/52946http://dx.doi.org/10.1002/evl3.165reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/grantAgreement/EC/H2020/663830© 2020 Marianne Dehasque et al. Evolution Letters published by Wiley Periodicals, Inc. on behalf of Society for the Study of Evolution (SSE) and European Society for Evolutionary Biology (ESEB). This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly citedhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/529462026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Inference of natural selection from ancient DNA |
| title |
Inference of natural selection from ancient DNA |
| spellingShingle |
Inference of natural selection from ancient DNA Dehasque, Marianne Adaptació (Biologia) ADN antic Selecció natural Genòmica |
| title_short |
Inference of natural selection from ancient DNA |
| title_full |
Inference of natural selection from ancient DNA |
| title_fullStr |
Inference of natural selection from ancient DNA |
| title_full_unstemmed |
Inference of natural selection from ancient DNA |
| title_sort |
Inference of natural selection from ancient DNA |
| dc.creator.none.fl_str_mv |
Dehasque, Marianne Ávila Arcos, María C. Díez-Del-Molino, David Fumagalli, Matteo Guschanski, Katerina Lorenzen, Eline D. Malaspinas, Anna-Sapfo Marquès i Bonet, Tomàs, 1975- Martin, Michael D. Murray, Gemma G. R. Papadopulos, Alexander S. T. Overgaard Therkildsen, Nina Wegmann, Daniel Dalén, Love Foote, Andrew D. |
| author |
Dehasque, Marianne |
| author_facet |
Dehasque, Marianne Ávila Arcos, María C. Díez-Del-Molino, David Fumagalli, Matteo Guschanski, Katerina Lorenzen, Eline D. Malaspinas, Anna-Sapfo Marquès i Bonet, Tomàs, 1975- Martin, Michael D. Murray, Gemma G. R. Papadopulos, Alexander S. T. Overgaard Therkildsen, Nina Wegmann, Daniel Dalén, Love Foote, Andrew D. |
| author_role |
author |
| author2 |
Ávila Arcos, María C. Díez-Del-Molino, David Fumagalli, Matteo Guschanski, Katerina Lorenzen, Eline D. Malaspinas, Anna-Sapfo Marquès i Bonet, Tomàs, 1975- Martin, Michael D. Murray, Gemma G. R. Papadopulos, Alexander S. T. Overgaard Therkildsen, Nina Wegmann, Daniel Dalén, Love Foote, Andrew D. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Adaptació (Biologia) ADN antic Selecció natural Genòmica |
| topic |
Adaptació (Biologia) ADN antic Selecció natural Genòmica |
| description |
Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. Sequencing ancient DNA from temporally spaced samples can inform about past selection processes, as time series data allow direct quantification of population parameters collected before, during, and after genetic changes driven by selection. In this Comment and Opinion, we advocate for the inclusion of temporal sampling and the generation of paleogenomic datasets in evolutionary biology, and highlight some of the recent advances that have yet to be broadly applied by evolutionary biologists. In doing so, we consider the expected signatures of balancing, purifying, and positive selection in time series data, and detail how this can advance our understanding of the chronology and tempo of genomic change driven by selection. However, we also recognize the limitations of such data, which can suffer from postmortem damage, fragmentation, low coverage, and typically low sample size. We therefore highlight the many assumptions and considerations associated with analyzing paleogenomic data and the assumptions associated with analytical methods. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2022 2022 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/52946 http://dx.doi.org/10.1002/evl3.165 |
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http://hdl.handle.net/10230/52946 http://dx.doi.org/10.1002/evl3.165 |
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Inglés |
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Inglés |
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info:eu-repo/grantAgreement/EC/H2020/663830 |
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http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf application/pdf |
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Wiley Open Access |
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Wiley Open Access |
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