From genetics to therapy: Unraveling the complexities of Richter transformation in chronic lymphocytic leukemia
Chronic lymphocytic leukemia; Clonal evolution; Richter's transformation
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/10286 |
| Acceso en línea: | https://hdl.handle.net/11351/10286 |
| Access Level: | acceso abierto |
| Palabra clave: | Leucèmia limfocítica crònica - Complicacions Trastorns limfoproliferatius - Tractament DISEASES::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Lymphoid::Leukemia, B-Cell::Leukemia, Lymphocytic, Chronic, B-Cell Other subheadings::Other subheadings::Other subheadings::/complications DISEASES::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, B-Cell::Lymphoma, Large B-Cell, Diffuse Other subheadings::Other subheadings::/therapy ENFERMEDADES::neoplasias::neoplasias por tipo histológico::leucemia::leucemia linfoide::leucemia de células B::leucemia linfocítica crónica de células B Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones ENFERMEDADES::neoplasias::neoplasias por tipo histológico::linfoma::linfoma no Hodgkin::linfoma de células B::linfoma de células B grandes difuso Otros calificadores::Otros calificadores::/terapia |
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From genetics to therapy: Unraveling the complexities of Richter transformation in chronic lymphocytic leukemia |
| title |
From genetics to therapy: Unraveling the complexities of Richter transformation in chronic lymphocytic leukemia |
| spellingShingle |
From genetics to therapy: Unraveling the complexities of Richter transformation in chronic lymphocytic leukemia Bosch-Schips, Jan Leucèmia limfocítica crònica - Complicacions Trastorns limfoproliferatius - Tractament DISEASES::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Lymphoid::Leukemia, B-Cell::Leukemia, Lymphocytic, Chronic, B-Cell Other subheadings::Other subheadings::Other subheadings::/complications DISEASES::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, B-Cell::Lymphoma, Large B-Cell, Diffuse Other subheadings::Other subheadings::/therapy ENFERMEDADES::neoplasias::neoplasias por tipo histológico::leucemia::leucemia linfoide::leucemia de células B::leucemia linfocítica crónica de células B Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones ENFERMEDADES::neoplasias::neoplasias por tipo histológico::linfoma::linfoma no Hodgkin::linfoma de células B::linfoma de células B grandes difuso Otros calificadores::Otros calificadores::/terapia |
| title_short |
From genetics to therapy: Unraveling the complexities of Richter transformation in chronic lymphocytic leukemia |
| title_full |
From genetics to therapy: Unraveling the complexities of Richter transformation in chronic lymphocytic leukemia |
| title_fullStr |
From genetics to therapy: Unraveling the complexities of Richter transformation in chronic lymphocytic leukemia |
| title_full_unstemmed |
From genetics to therapy: Unraveling the complexities of Richter transformation in chronic lymphocytic leukemia |
| title_sort |
From genetics to therapy: Unraveling the complexities of Richter transformation in chronic lymphocytic leukemia |
| dc.creator.none.fl_str_mv |
Bosch-Schips, Jan Nadeu, Ferran Cabirta, Alba Abrisqueta, Pau IACOBONI, GLORIA Serna, Angel Bosch, Francesc |
| author |
Bosch-Schips, Jan |
| author_facet |
Bosch-Schips, Jan Nadeu, Ferran Cabirta, Alba Abrisqueta, Pau IACOBONI, GLORIA Serna, Angel Bosch, Francesc |
| author_role |
author |
| author2 |
Nadeu, Ferran Cabirta, Alba Abrisqueta, Pau IACOBONI, GLORIA Serna, Angel Bosch, Francesc |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Abrisqueta P, Iacoboni G, Serna A, Cabirta A, Bosch F] Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Nadeu F] Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. Department of Pathology, Hospital Universitari de Bellvitge-Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. [Bosch-Schips J] Department of Pathology, Hospital Universitari de Bellvitge-Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Leucèmia limfocítica crònica - Complicacions Trastorns limfoproliferatius - Tractament DISEASES::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Lymphoid::Leukemia, B-Cell::Leukemia, Lymphocytic, Chronic, B-Cell Other subheadings::Other subheadings::Other subheadings::/complications DISEASES::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, B-Cell::Lymphoma, Large B-Cell, Diffuse Other subheadings::Other subheadings::/therapy ENFERMEDADES::neoplasias::neoplasias por tipo histológico::leucemia::leucemia linfoide::leucemia de células B::leucemia linfocítica crónica de células B Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones ENFERMEDADES::neoplasias::neoplasias por tipo histológico::linfoma::linfoma no Hodgkin::linfoma de células B::linfoma de células B grandes difuso Otros calificadores::Otros calificadores::/terapia |
| topic |
Leucèmia limfocítica crònica - Complicacions Trastorns limfoproliferatius - Tractament DISEASES::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Lymphoid::Leukemia, B-Cell::Leukemia, Lymphocytic, Chronic, B-Cell Other subheadings::Other subheadings::Other subheadings::/complications DISEASES::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, B-Cell::Lymphoma, Large B-Cell, Diffuse Other subheadings::Other subheadings::/therapy ENFERMEDADES::neoplasias::neoplasias por tipo histológico::leucemia::leucemia linfoide::leucemia de células B::leucemia linfocítica crónica de células B Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones ENFERMEDADES::neoplasias::neoplasias por tipo histológico::linfoma::linfoma no Hodgkin::linfoma de células B::linfoma de células B grandes difuso Otros calificadores::Otros calificadores::/terapia |
| description |
Chronic lymphocytic leukemia; Clonal evolution; Richter's transformation |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023 2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/10286 |
| url |
https://hdl.handle.net/11351/10286 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Cancer Treatment Reviews;120 https://doi.org/10.1016/j.ctrv.2023.102619 info:eu-repo/grantAgreement/ES/PE2013-2016/PI18%2F01392 |
| dc.rights.none.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
| instname_str |
Departament de Salut de la Generalitat de Catalunya (DS) |
| reponame_str |
Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| collection |
Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869414387059523584 |
| spelling |
From genetics to therapy: Unraveling the complexities of Richter transformation in chronic lymphocytic leukemiaBosch-Schips, JanNadeu, FerranCabirta, AlbaAbrisqueta, PauIACOBONI, GLORIASerna, AngelBosch, FrancescLeucèmia limfocítica crònica - ComplicacionsTrastorns limfoproliferatius - TractamentDISEASES::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Lymphoid::Leukemia, B-Cell::Leukemia, Lymphocytic, Chronic, B-CellOther subheadings::Other subheadings::Other subheadings::/complicationsDISEASES::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, B-Cell::Lymphoma, Large B-Cell, DiffuseOther subheadings::Other subheadings::/therapyENFERMEDADES::neoplasias::neoplasias por tipo histológico::leucemia::leucemia linfoide::leucemia de células B::leucemia linfocítica crónica de células BOtros calificadores::Otros calificadores::Otros calificadores::/complicacionesENFERMEDADES::neoplasias::neoplasias por tipo histológico::linfoma::linfoma no Hodgkin::linfoma de células B::linfoma de células B grandes difusoOtros calificadores::Otros calificadores::/terapiaChronic lymphocytic leukemia; Clonal evolution; Richter's transformationLeucèmia limfocítica crònica; Evolució clonal; Transformació de RichterLeucemia linfocítica crónica; Evolución clonal; Transformación de RichterRichter transformation (RT) refers to the progression of chronic lymphocytic leukemia, the most prevalent leukemia among adults, into a highly aggressive lymphoproliferative disorder, primarily a diffuse large B-cell lymphoma. This is a severe complication that continues to be a therapeutic challenge and remains an unmet medical need. Over the last five years, significant advances have occurred in uncovering the biological processes leading to the RT, refining criteria for properly diagnose RT from other entities, and exploring new therapeutic options beyond the ineffective chemotherapy. This review summarizes current knowledge in RT, including recent advances in the understanding of the pathogenesis of RT, in the classification of RT, and in the development of novel therapeutic strategies for this grave complication.This work was supported in part by the Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias [PI17/00943, F.B, PI18/01392, P.A.], and Gilead Fellowships, United States [GLD18/00047, F.B.] and Fundació la Marató de TV3, Spain [201905-30-31 F.B]. F.N. acknowledges research support from the American Association for Cancer Research (2021 AACR-Amgen Fellowship in Clinical/Translational Cancer Research, 21-40-11-NADE), the European Hematology Association (EHA Junior Research Grant 2021, RG-202012-00245), the Lady Tata Memorial Trust, India (International Award for Research in Leukaemia 2021–2022, LADY_TATA_21_3223).ElsevierInstitut Català de la Salut[Abrisqueta P, Iacoboni G, Serna A, Cabirta A, Bosch F] Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Nadeu F] Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. Department of Pathology, Hospital Universitari de Bellvitge-Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. [Bosch-Schips J] Department of Pathology, Hospital Universitari de Bellvitge-Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/10286Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésCancer Treatment Reviews;120https://doi.org/10.1016/j.ctrv.2023.102619info:eu-repo/grantAgreement/ES/PE2013-2016/PI18%2F01392Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/102862026-06-12T09:38:37Z |
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15,812455 |