Dysbiotic microbiota interactions in Crohn's disease.

Crohn's disease (CD) is a major form of inflammatory bowel disease characterized by transmural inflammation along the alimentary tract. Changes in the microbial composition and reduction in species diversity are recognized as pivotal hallmarks in disease dynamics, challenging the gut barrier fu...

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Authors: Caparrós E, Wiest R, Scharl M, Rogler G, Gutiérrez Casbas A, Yilmaz B, Wawrzyniak M, Francés R
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repository:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p7353
Online Access:https://isabial.portalinvestigacion.com/publicaciones7353
Access Level:Open access
Keyword:*Crohn’s disease
*bacterial translocation
*dysbiosis
*fibrosis
*inflammation
*microbiota
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spelling Dysbiotic microbiota interactions in Crohn's disease.Caparrós EWiest RScharl MRogler GGutiérrez Casbas AYilmaz BWawrzyniak MFrancés R*Crohn’s disease*bacterial translocation*dysbiosis*fibrosis*inflammation*microbiotaCrohn's disease (CD) is a major form of inflammatory bowel disease characterized by transmural inflammation along the alimentary tract. Changes in the microbial composition and reduction in species diversity are recognized as pivotal hallmarks in disease dynamics, challenging the gut barrier function and shaping a pathological immune response in genetically influenced subjects. The purpose of this review is to delve into the modification of the gut microbiota cluster network during CD progression and to discuss how this shift compromises the gut barrier integrity, granting the translocation of microbes and their products. We then complete the scope of the review by retracing gut microbiota dysbiosis interactions with the main pathophysiologic factors of CD, starting from the host's genetic background to the immune inflammatory and fibrotic processes, providing a standpoint on the lifestyle/exogenous factors and the potential benefits of targeting a specific gut microbiota.TAYLOR & FRANCIS INC2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones7353Gut MicrobesISSN: 19490976ISSNe: 19490984reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p73532026-06-12T10:20:37Z
dc.title.none.fl_str_mv Dysbiotic microbiota interactions in Crohn's disease.
title Dysbiotic microbiota interactions in Crohn's disease.
spellingShingle Dysbiotic microbiota interactions in Crohn's disease.
Caparrós E
*Crohn’s disease
*bacterial translocation
*dysbiosis
*fibrosis
*inflammation
*microbiota
title_short Dysbiotic microbiota interactions in Crohn's disease.
title_full Dysbiotic microbiota interactions in Crohn's disease.
title_fullStr Dysbiotic microbiota interactions in Crohn's disease.
title_full_unstemmed Dysbiotic microbiota interactions in Crohn's disease.
title_sort Dysbiotic microbiota interactions in Crohn's disease.
dc.creator.none.fl_str_mv Caparrós E
Wiest R
Scharl M
Rogler G
Gutiérrez Casbas A
Yilmaz B
Wawrzyniak M
Francés R
author Caparrós E
author_facet Caparrós E
Wiest R
Scharl M
Rogler G
Gutiérrez Casbas A
Yilmaz B
Wawrzyniak M
Francés R
author_role author
author2 Wiest R
Scharl M
Rogler G
Gutiérrez Casbas A
Yilmaz B
Wawrzyniak M
Francés R
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv *Crohn’s disease
*bacterial translocation
*dysbiosis
*fibrosis
*inflammation
*microbiota
topic *Crohn’s disease
*bacterial translocation
*dysbiosis
*fibrosis
*inflammation
*microbiota
description Crohn's disease (CD) is a major form of inflammatory bowel disease characterized by transmural inflammation along the alimentary tract. Changes in the microbial composition and reduction in species diversity are recognized as pivotal hallmarks in disease dynamics, challenging the gut barrier function and shaping a pathological immune response in genetically influenced subjects. The purpose of this review is to delve into the modification of the gut microbiota cluster network during CD progression and to discuss how this shift compromises the gut barrier integrity, granting the translocation of microbes and their products. We then complete the scope of the review by retracing gut microbiota dysbiosis interactions with the main pathophysiologic factors of CD, starting from the host's genetic background to the immune inflammatory and fibrotic processes, providing a standpoint on the lifestyle/exogenous factors and the potential benefits of targeting a specific gut microbiota.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones7353
url https://isabial.portalinvestigacion.com/publicaciones7353
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv TAYLOR & FRANCIS INC
publisher.none.fl_str_mv TAYLOR & FRANCIS INC
dc.source.none.fl_str_mv Gut Microbes
ISSN: 19490976
ISSNe: 19490984
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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