Renal and Neurologic Benefit of Levosimendan vs Dobutamine in Patients With Low Cardiac Output Syndrome After Cardiac Surgery: Clinical Trial FIM-BGC-2014-01.

Low-cardiac output syndrome (LCOS) after cardiac surgery secondary to systemic hypoperfusion is associated with a higher incidence of renal and neurological damage. A range of effective therapies are available for LCOS. The beneficial systemic effects of levosimendan persist even after cardiac outpu...

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Authors: Guerrero-Orriach, Jose L, Malo-Manso, Alfredo, Ramirez-Aliaga, Marta, Florez Vela, Ana Isabel, Galán-Ortega, Manuel, Moreno-Cortes, Isabel, Gonzalez-Almendros, Inmaculada, Ramirez-Fernandez, Alicia, Ariza-Villanueva, Daniel, Escalona-Belmonte, Juan Jose, Quesada-Muñoz, Guillermo, Sepúlveda-Haro, Enrique, Romero-Molina, Salvador, Bellido-Estevez, Inmaculada, Gomez-Luque, Aurelio, Rubio-Navarro, Manuel, Alcaide-Torres, Juan, Santiago-Fernandez, Concepcion, Garrido-Sanchez, Lourdes, Cruz-Mañas, Jose
Format: article
Publication Date:2020
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18104
Online Access:http://hdl.handle.net/20.500.12105/18104
Access Level:Open access
Keyword:Cardiac surgery
Dobutamine
Kidney
Levosimendan
Low cardiac output
Description
Summary:Low-cardiac output syndrome (LCOS) after cardiac surgery secondary to systemic hypoperfusion is associated with a higher incidence of renal and neurological damage. A range of effective therapies are available for LCOS. The beneficial systemic effects of levosimendan persist even after cardiac output is restored, which suggests an independent cardioprotective effect. A double-blind clinical trial was conducted in patients with a confirmed diagnosis of LCOS randomized into two treatment groups (levosimendan vs. dobutamine). Monitoring of hemodynamic (cardiac index, systolic volume index, heart rate, mean arterial pressure, central venous pressure, central venous saturation); biochemical (e.g. creatinine, S100B protein, NT-proBNP, troponin I); and renal parameters was performed using acute kidney injury scale (AKI scale) and renal and brain ultrasound measurements [vascular resistance index (VRI)] at diagnosis and during the first 48 h. Significant differences were observed between groups in terms of cardiac index, systolic volume index, NT-proBNP, and kidney injury stage at diagnosis. In the levosimendan group, there were significant variations in AKI stage after 24 and 48 h. No significant differences were observed in the other parameters studied. Levosimendan showed a beneficial effect on renal function in LCOS patients after cardiac surgery that was independent from cardiac output and vascular tone. This effect is probably achieved by pharmacological postconditioning. EUDRA CT, identifier 2014-001461-27. https://www.clinicaltrialsregister.eu/ctr-search/search?query=2014-001461-27.

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