Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologics

Asma pediátrica grave; Niños; Medicamentos biológicos

Detalles Bibliográficos
Autores: Liu, Norrice, Pijnenburg, Mariëlle W., Deschildre, Antoine, Adalen, Sigve, Amat, Flore, Bravo López, Maynor Guillermo, de Mir Messa, Ines
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/13962
Acceso en línea:http://hdl.handle.net/11351/13962
Access Level:acceso abierto
Palabra clave:Infants
Asma - Tractament
Medicaments biològics - Ús terapèutic
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Asthma
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Complex Mixtures::Biological Products
Other subheadings::Other subheadings::/therapeutic use
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::asma
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::mezclas complejas::productos biológicos
Otros calificadores::Otros calificadores::/uso terapéutico
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologicsLiu, NorricePijnenburg, Mariëlle W.Deschildre, AntoineAdalen, SigveAmat, FloreBravo López, Maynor Guillermode Mir Messa, InesInfantsAsma - TractamentMedicaments biològics - Ús terapèuticDISEASES::Respiratory Tract Diseases::Bronchial Diseases::AsthmaOther subheadings::Other subheadings::Other subheadings::/drug therapyCHEMICALS AND DRUGS::Complex Mixtures::Biological ProductsOther subheadings::Other subheadings::/therapeutic useENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::asmaOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaCOMPUESTOS QUÍMICOS Y DROGAS::mezclas complejas::productos biológicosOtros calificadores::Otros calificadores::/uso terapéuticoAsma pediátrica grave; Niños; Medicamentos biológicosAsma pediàtrica greu; Nens; Medicaments biològicsSevere paediatric asthma; Children; Biologics drugsIntroduction Real-world data on children with severe asthma is scarce. We report characteristics of children with severe asthma already on biologics, enrolled in the Severe Paediatric Asthma Collaborative in Europe, a clinical research collaboration of the European Respiratory Society. Methods We describe patient's characteristics including asthma control assessed with Global Initiative for Asthma (GINA) criteria, composite asthma severity index (CASI), exacerbations, unscheduled medical attendances, lung function and quality of life in children on biologic treatment because of severe asthma. We also assessed previous biologics use. Forced expiratory volume in 1 s, CASI, GINA, Paediatric Asthma Quality of Life Questionnaire score, exacerbations, unscheduled medical attendance and hospital admission comparisons in patients treated with different biologics were adjusted by age, sex and biologic therapy duration. Results Among the 250 children (median age 13.2 years) recruited, 56.8% used omalizumab, 21.6% mepolizumab and 21.6% dupilumab. At enrolment, the dupilumab group was older (median 15.0 years), while the omalizumab group had been on biologic treatment the longest (median 622 days). Overall, 27% and 8% had partly controlled and uncontrolled asthma respectively, according to GINA. In the last 12 months, 52% and 29% had at least one and two exacerbations, respectively; airflow obstruction was found in 33%. 10% were admitted to hospital due to exacerbation. A previous switch from another biologic was recorded in 16%, predominantly due to nonresponse. Conclusions Most children on biologics obtained good symptom control, but many still experienced asthma attacks. Switching between biologics was substantial. There is still an unmet need in severe paediatric asthma.European Respiratory SocietyInstitut Català de la Salut[Liu NM] Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, UK. [Pijnenburg MW] Erasmus University Medical Centre, Rotterdam, The Netherlands. [Deschildre A] Hôpital Jeanne de Flandre, CHU Lille, France. [de Mir-Messa I, Bravo-Lopez M] Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Adalen S] Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. [Amat F] Assistance Publique – Hôpitaux de Paris Robert Debré Hospital, Paris, France - INSERM 1018 - Centre de Recherche en Epidémiologie et Santé des Populations, Epidémiologie Respiratoire Intégrative, Villejuif, FranceVall d'Hebron Barcelona Hospital Campus202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/13962Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésERJ Open Research;11(3)https://doi.org/10.1183/23120541.00709-2024Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/139622026-06-12T09:38:37Z
dc.title.none.fl_str_mv Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologics
title Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologics
spellingShingle Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologics
Liu, Norrice
Infants
Asma - Tractament
Medicaments biològics - Ús terapèutic
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Asthma
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Complex Mixtures::Biological Products
Other subheadings::Other subheadings::/therapeutic use
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::asma
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::mezclas complejas::productos biológicos
Otros calificadores::Otros calificadores::/uso terapéutico
title_short Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologics
title_full Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologics
title_fullStr Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologics
title_full_unstemmed Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologics
title_sort Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologics
dc.creator.none.fl_str_mv Liu, Norrice
Pijnenburg, Mariëlle W.
Deschildre, Antoine
Adalen, Sigve
Amat, Flore
Bravo López, Maynor Guillermo
de Mir Messa, Ines
author Liu, Norrice
author_facet Liu, Norrice
Pijnenburg, Mariëlle W.
Deschildre, Antoine
Adalen, Sigve
Amat, Flore
Bravo López, Maynor Guillermo
de Mir Messa, Ines
author_role author
author2 Pijnenburg, Mariëlle W.
Deschildre, Antoine
Adalen, Sigve
Amat, Flore
Bravo López, Maynor Guillermo
de Mir Messa, Ines
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Liu NM] Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, UK. [Pijnenburg MW] Erasmus University Medical Centre, Rotterdam, The Netherlands. [Deschildre A] Hôpital Jeanne de Flandre, CHU Lille, France. [de Mir-Messa I, Bravo-Lopez M] Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Adalen S] Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. [Amat F] Assistance Publique – Hôpitaux de Paris Robert Debré Hospital, Paris, France - INSERM 1018 - Centre de Recherche en Epidémiologie et Santé des Populations, Epidémiologie Respiratoire Intégrative, Villejuif, France
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Infants
Asma - Tractament
Medicaments biològics - Ús terapèutic
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Asthma
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Complex Mixtures::Biological Products
Other subheadings::Other subheadings::/therapeutic use
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::asma
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::mezclas complejas::productos biológicos
Otros calificadores::Otros calificadores::/uso terapéutico
topic Infants
Asma - Tractament
Medicaments biològics - Ús terapèutic
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Asthma
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Complex Mixtures::Biological Products
Other subheadings::Other subheadings::/therapeutic use
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::asma
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::mezclas complejas::productos biológicos
Otros calificadores::Otros calificadores::/uso terapéutico
description Asma pediátrica grave; Niños; Medicamentos biológicos
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11351/13962
url http://hdl.handle.net/11351/13962
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv ERJ Open Research;11(3)
https://doi.org/10.1183/23120541.00709-2024
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv European Respiratory Society
publisher.none.fl_str_mv European Respiratory Society
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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