Influence of heterogeneous age-group contact patterns on critical vaccination rates for herd immunity to SARS-CoV-2

Currently, several western countries have more than half of their population fully vaccinated against COVID-19. At the same time, some of them are experiencing a fourth or even a fifth wave of cases, most of them concentrated in sectors of the populations whose vaccination coverage is lower than the...

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Detalles Bibliográficos
Autores: Saldaña Meca, Joan, Scoglio, Caterina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/20708
Acceso en línea:http://hdl.handle.net/10256/20708
Access Level:acceso abierto
Palabra clave:Pandèmia de COVID-19, 2020- -- Models matemàtics
COVID-19 Pandemic, 2020- -- Mathematical models
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spelling Influence of heterogeneous age-group contact patterns on critical vaccination rates for herd immunity to SARS-CoV-2Saldaña Meca, JoanScoglio, CaterinaPandèmia de COVID-19, 2020- -- Models matemàticsCOVID-19 Pandemic, 2020- -- Mathematical modelsCurrently, several western countries have more than half of their population fully vaccinated against COVID-19. At the same time, some of them are experiencing a fourth or even a fifth wave of cases, most of them concentrated in sectors of the populations whose vaccination coverage is lower than the average. So, the initial scenario of vaccine prioritization has given way to a new one where achieving herd immunity is the primary concern. Using an age-structured vaccination model with waning immunity, we show that, under a limited supply of vaccines, a vaccination strategy based on minimizing the basic reproduction number allows for the deployment of a number of vaccine doses lower than the one required for maximizing the vaccination coverage. Such minimization is achieved by giving greater protection to those age groups that, for a given social contact pattern, have smaller fractions of susceptible individuals at the endemic equilibrium without vaccination, that is, to those groups that are more vulnerable to infectionNature Publishing GroupAgencia Estatal de Investigación2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/20708http://hdl.handle.net/10256/20708Scientific Reports, 2022, vol. 12, art. núm. 2640Articles publicats (D-IMAE)Saldaña Meca, Joan Scoglio, Caterina 2022 Influence of heterogeneous age-group contact patterns on critical vaccination rates for herd immunity to SARS-CoV-2 Scientific Reports 12 2640reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-022-06477-0info:eu-repo/semantics/altIdentifier/eissn/2045-2322info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104437GB-I00Attribution 4.0 International (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/207082026-05-29T05:05:01Z
dc.title.none.fl_str_mv Influence of heterogeneous age-group contact patterns on critical vaccination rates for herd immunity to SARS-CoV-2
title Influence of heterogeneous age-group contact patterns on critical vaccination rates for herd immunity to SARS-CoV-2
spellingShingle Influence of heterogeneous age-group contact patterns on critical vaccination rates for herd immunity to SARS-CoV-2
Saldaña Meca, Joan
Pandèmia de COVID-19, 2020- -- Models matemàtics
COVID-19 Pandemic, 2020- -- Mathematical models
title_short Influence of heterogeneous age-group contact patterns on critical vaccination rates for herd immunity to SARS-CoV-2
title_full Influence of heterogeneous age-group contact patterns on critical vaccination rates for herd immunity to SARS-CoV-2
title_fullStr Influence of heterogeneous age-group contact patterns on critical vaccination rates for herd immunity to SARS-CoV-2
title_full_unstemmed Influence of heterogeneous age-group contact patterns on critical vaccination rates for herd immunity to SARS-CoV-2
title_sort Influence of heterogeneous age-group contact patterns on critical vaccination rates for herd immunity to SARS-CoV-2
dc.creator.none.fl_str_mv Saldaña Meca, Joan
Scoglio, Caterina
author Saldaña Meca, Joan
author_facet Saldaña Meca, Joan
Scoglio, Caterina
author_role author
author2 Scoglio, Caterina
author2_role author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación
dc.subject.none.fl_str_mv Pandèmia de COVID-19, 2020- -- Models matemàtics
COVID-19 Pandemic, 2020- -- Mathematical models
topic Pandèmia de COVID-19, 2020- -- Models matemàtics
COVID-19 Pandemic, 2020- -- Mathematical models
description Currently, several western countries have more than half of their population fully vaccinated against COVID-19. At the same time, some of them are experiencing a fourth or even a fifth wave of cases, most of them concentrated in sectors of the populations whose vaccination coverage is lower than the average. So, the initial scenario of vaccine prioritization has given way to a new one where achieving herd immunity is the primary concern. Using an age-structured vaccination model with waning immunity, we show that, under a limited supply of vaccines, a vaccination strategy based on minimizing the basic reproduction number allows for the deployment of a number of vaccine doses lower than the one required for maximizing the vaccination coverage. Such minimization is achieved by giving greater protection to those age groups that, for a given social contact pattern, have smaller fractions of susceptible individuals at the endemic equilibrium without vaccination, that is, to those groups that are more vulnerable to infection
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/20708
http://hdl.handle.net/10256/20708
url http://hdl.handle.net/10256/20708
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-022-06477-0
info:eu-repo/semantics/altIdentifier/eissn/2045-2322
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104437GB-I00
dc.rights.none.fl_str_mv Attribution 4.0 International (CC BY 4.0)
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International (CC BY 4.0)
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Scientific Reports, 2022, vol. 12, art. núm. 2640
Articles publicats (D-IMAE)
Saldaña Meca, Joan Scoglio, Caterina 2022 Influence of heterogeneous age-group contact patterns on critical vaccination rates for herd immunity to SARS-CoV-2 Scientific Reports 12 2640
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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