Modelling of chemotatic sprouting endothelial cells through and extracellular matrix

Sprouting angiogenesis is a core biological process critical to vascular development. Its accurate simulation, relevant to multiple facets of human health, is of broad, interdisciplinary appeal. This study presents an in-silico model replicating a microfluidic assay where endothelial cells sprout in...

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Autores: Ferré Torres, Josep, Noguera Monteagudo, Adrià, López Canosa, Adrián, Romero Arias, J. Roberto, Barrio, Rafael, Castaño Linares, Óscar, Hernández Machado, Aurora
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/219719
Acceso en línea:https://hdl.handle.net/2445/219719
Access Level:acceso abierto
Palabra clave:Angiogènesi
Biomimètica
Neovascularization
Biomimetics
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spelling Modelling of chemotatic sprouting endothelial cells through and extracellular matrixFerré Torres, JosepNoguera Monteagudo, AdriàLópez Canosa, AdriánRomero Arias, J. RobertoBarrio, RafaelCastaño Linares, ÓscarHernández Machado, AuroraAngiogènesiBiomimèticaNeovascularizationBiomimeticsSprouting angiogenesis is a core biological process critical to vascular development. Its accurate simulation, relevant to multiple facets of human health, is of broad, interdisciplinary appeal. This study presents an in-silico model replicating a microfluidic assay where endothelial cells sprout into a biomimetic extracellular matrix, specifically, a large-pore, low-concentration fibrin-based porous hydrogel, influenced by chemotactic factors. We introduce a novel approach by incorporating the extracellular matrix and chemotactic factor effects into a unified term using a single parameter, primarily focusing on modelling sprouting dynamics and morphology. This continuous model naturally describes chemotactic-induced sprouting with no need for additional rules. In addition, we extended our base model to account for matrix sensing and degradation, crucial aspects of angiogenesis. We validate our model via a hybrid in-silico experimental method, comparing the model predictions with experimental results derived from the microfluidic setup. Our results underscore the intricate relationship between the extracellular matrix structure and angiogenic sprouting, proposing a promising method for predicting the influence of the extracellular matrix on angiogenesis.Frontiers Media2025202520232025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/219719Articles publicats en revistes (Física de la Matèria Condensada)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fbioe.2023.1145550Frontiers In Bioengineering And Biotechnology, 2023https://doi.org/10.3389/fbioe.2023.1145550cc-by (c) Ferre-Torres, J et al., 2023http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2197192026-05-29T05:05:01Z
dc.title.none.fl_str_mv Modelling of chemotatic sprouting endothelial cells through and extracellular matrix
title Modelling of chemotatic sprouting endothelial cells through and extracellular matrix
spellingShingle Modelling of chemotatic sprouting endothelial cells through and extracellular matrix
Ferré Torres, Josep
Angiogènesi
Biomimètica
Neovascularization
Biomimetics
title_short Modelling of chemotatic sprouting endothelial cells through and extracellular matrix
title_full Modelling of chemotatic sprouting endothelial cells through and extracellular matrix
title_fullStr Modelling of chemotatic sprouting endothelial cells through and extracellular matrix
title_full_unstemmed Modelling of chemotatic sprouting endothelial cells through and extracellular matrix
title_sort Modelling of chemotatic sprouting endothelial cells through and extracellular matrix
dc.creator.none.fl_str_mv Ferré Torres, Josep
Noguera Monteagudo, Adrià
López Canosa, Adrián
Romero Arias, J. Roberto
Barrio, Rafael
Castaño Linares, Óscar
Hernández Machado, Aurora
author Ferré Torres, Josep
author_facet Ferré Torres, Josep
Noguera Monteagudo, Adrià
López Canosa, Adrián
Romero Arias, J. Roberto
Barrio, Rafael
Castaño Linares, Óscar
Hernández Machado, Aurora
author_role author
author2 Noguera Monteagudo, Adrià
López Canosa, Adrián
Romero Arias, J. Roberto
Barrio, Rafael
Castaño Linares, Óscar
Hernández Machado, Aurora
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Angiogènesi
Biomimètica
Neovascularization
Biomimetics
topic Angiogènesi
Biomimètica
Neovascularization
Biomimetics
description Sprouting angiogenesis is a core biological process critical to vascular development. Its accurate simulation, relevant to multiple facets of human health, is of broad, interdisciplinary appeal. This study presents an in-silico model replicating a microfluidic assay where endothelial cells sprout into a biomimetic extracellular matrix, specifically, a large-pore, low-concentration fibrin-based porous hydrogel, influenced by chemotactic factors. We introduce a novel approach by incorporating the extracellular matrix and chemotactic factor effects into a unified term using a single parameter, primarily focusing on modelling sprouting dynamics and morphology. This continuous model naturally describes chemotactic-induced sprouting with no need for additional rules. In addition, we extended our base model to account for matrix sensing and degradation, crucial aspects of angiogenesis. We validate our model via a hybrid in-silico experimental method, comparing the model predictions with experimental results derived from the microfluidic setup. Our results underscore the intricate relationship between the extracellular matrix structure and angiogenic sprouting, proposing a promising method for predicting the influence of the extracellular matrix on angiogenesis.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/219719
url https://hdl.handle.net/2445/219719
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fbioe.2023.1145550
Frontiers In Bioengineering And Biotechnology, 2023
https://doi.org/10.3389/fbioe.2023.1145550
dc.rights.none.fl_str_mv cc-by (c) Ferre-Torres, J et al., 2023
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Ferre-Torres, J et al., 2023
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Física de la Matèria Condensada)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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