The 'unnatural' history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance

Ahadova, Aysel; Seppälä, Toni T.; Engel, Christoph; Gallon, Richard; Burn, John; Holinski Feder, Elke; Steinke-Lange, Verena; Möslein, Gabriela; Nielsen, Maartje; Ten Broeke, Sanne W.; Laghi, Luigi; Dominguez Valentin, Mev; Capellá, G. (Gabriel); Macrae, Finlay; Scott, Rodney J.; Hüneburg, Robert; Nattermann, Jacob; Hoffmeister, Michael; Brenner, Hermann; Bläker, Hendrik; von Knebel Doeberitz, Magnus; Sampson, Julian R.; Vasen, Hans; Mecklin, Jukka-Pekka; Møller, Pål; Kloor, Matthias

The 'unnatural' history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance

Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent stud...

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Detalles Bibliográficos
Autores:	Ahadova, Aysel, Seppälä, Toni T., Engel, Christoph, Gallon, Richard, Burn, John, Holinski Feder, Elke, Steinke-Lange, Verena, Möslein, Gabriela, Nielsen, Maartje, Ten Broeke, Sanne W., Laghi, Luigi, Dominguez Valentin, Mev, Capellá, G. (Gabriel), Macrae, Finlay, Scott, Rodney J., Hüneburg, Robert, Nattermann, Jacob, Hoffmeister, Michael, Brenner, Hermann, Bläker, Hendrik, von Knebel Doeberitz, Magnus, Sampson, Julian R., Vasen, Hans, Mecklin, Jukka-Pekka, Møller, Pål, Kloor, Matthias
Tipo de recurso:	artículo
Estado:	Versión aceptada para publicación
Fecha de publicación:	2021
País:	España
Institución:	Universidad de Barcelona
Repositorio:	Dipòsit Digital de la UB
OAI Identifier:	oai:diposit.ub.edu:2445/175251
Acceso en línea:	https://hdl.handle.net/2445/175251
Access Level:	acceso abierto
Palabra clave:	Càncer colorectal Colonoscòpia Colorectal cancer Colonoscopy

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spelling	The 'unnatural' history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillanceAhadova, AyselSeppälä, Toni T.Engel, ChristophGallon, RichardBurn, JohnHolinski Feder, ElkeSteinke-Lange, VerenaMöslein, GabrielaNielsen, MaartjeTen Broeke, Sanne W.Laghi, LuigiDominguez Valentin, MevCapellá, G. (Gabriel)Macrae, FinlayScott, Rodney J.Hüneburg, RobertNattermann, JacobHoffmeister, MichaelBrenner, HermannBläker, Hendrikvon Knebel Doeberitz, MagnusSampson, Julian R.Vasen, HansMecklin, Jukka-PekkaMøller, PålKloor, MatthiasCàncer colorectalColonoscòpiaColorectal cancerColonoscopyIndividuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS-associated CRC. Alongside with hypotheses addressing colonoscopy quality and pace of progression from adenoma to cancer, we discuss the role of alternative precursors and immune system in LS-associated CRC. We also identify gaps in current knowledge and make suggestions for future studies aiming at improved CRC prevention for LS individuals.Wiley2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/175251Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1002/ijc.33224International Journal of Cancer, 2021, vol. 148(4), p. 800-811https://doi.org/10.1002/ijc.33224(c) CC BY-NC-ND Ahadova, et. al., 2020http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1752512026-05-27T06:46:51Z
dc.title.none.fl_str_mv	The 'unnatural' history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
title	The 'unnatural' history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
spellingShingle	The 'unnatural' history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance Ahadova, Aysel Càncer colorectal Colonoscòpia Colorectal cancer Colonoscopy
title_short	The 'unnatural' history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
title_full	The 'unnatural' history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
title_fullStr	The 'unnatural' history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
title_full_unstemmed	The 'unnatural' history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
title_sort	The 'unnatural' history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
dc.creator.none.fl_str_mv	Ahadova, Aysel Seppälä, Toni T. Engel, Christoph Gallon, Richard Burn, John Holinski Feder, Elke Steinke-Lange, Verena Möslein, Gabriela Nielsen, Maartje Ten Broeke, Sanne W. Laghi, Luigi Dominguez Valentin, Mev Capellá, G. (Gabriel) Macrae, Finlay Scott, Rodney J. Hüneburg, Robert Nattermann, Jacob Hoffmeister, Michael Brenner, Hermann Bläker, Hendrik von Knebel Doeberitz, Magnus Sampson, Julian R. Vasen, Hans Mecklin, Jukka-Pekka Møller, Pål Kloor, Matthias
author	Ahadova, Aysel
author_facet	Ahadova, Aysel Seppälä, Toni T. Engel, Christoph Gallon, Richard Burn, John Holinski Feder, Elke Steinke-Lange, Verena Möslein, Gabriela Nielsen, Maartje Ten Broeke, Sanne W. Laghi, Luigi Dominguez Valentin, Mev Capellá, G. (Gabriel) Macrae, Finlay Scott, Rodney J. Hüneburg, Robert Nattermann, Jacob Hoffmeister, Michael Brenner, Hermann Bläker, Hendrik von Knebel Doeberitz, Magnus Sampson, Julian R. Vasen, Hans Mecklin, Jukka-Pekka Møller, Pål Kloor, Matthias
author_role	author
author2	Seppälä, Toni T. Engel, Christoph Gallon, Richard Burn, John Holinski Feder, Elke Steinke-Lange, Verena Möslein, Gabriela Nielsen, Maartje Ten Broeke, Sanne W. Laghi, Luigi Dominguez Valentin, Mev Capellá, G. (Gabriel) Macrae, Finlay Scott, Rodney J. Hüneburg, Robert Nattermann, Jacob Hoffmeister, Michael Brenner, Hermann Bläker, Hendrik von Knebel Doeberitz, Magnus Sampson, Julian R. Vasen, Hans Mecklin, Jukka-Pekka Møller, Pål Kloor, Matthias
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Càncer colorectal Colonoscòpia Colorectal cancer Colonoscopy
topic	Càncer colorectal Colonoscòpia Colorectal cancer Colonoscopy
description	Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS-associated CRC. Alongside with hypotheses addressing colonoscopy quality and pace of progression from adenoma to cancer, we discuss the role of alternative precursors and immune system in LS-associated CRC. We also identify gaps in current knowledge and make suggestions for future studies aiming at improved CRC prevention for LS individuals.
publishDate	2021
dc.date.none.fl_str_mv	2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion info:eu-repo/semantics/publishedVersion
format	article
status_str	acceptedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/175251
url	https://hdl.handle.net/2445/175251
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1002/ijc.33224 International Journal of Cancer, 2021, vol. 148(4), p. 800-811 https://doi.org/10.1002/ijc.33224
dc.rights.none.fl_str_mv	(c) CC BY-NC-ND Ahadova, et. al., 2020 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	(c) CC BY-NC-ND Ahadova, et. al., 2020 http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Wiley
publisher.none.fl_str_mv	Wiley
dc.source.none.fl_str_mv	Articles publicats en revistes (Ciències Clíniques) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona
instname_str	Universidad de Barcelona
reponame_str	Dipòsit Digital de la UB
collection	Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,300719

The 'unnatural' history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance

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