The prostaglandin D receptor 2 pathway in asthma
Asthma is characterised by chronic airway inflammation, airway obstruction and hyper-responsiveness. The inflammatory cascade in asthma comprises a complex interplay of genetic factors, the airway epithelium, and dysregulation of the immune response. Prostaglandin D (PGD) is a lipid mediator, predom...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:253660 |
| Acceso en línea: | https://ddd.uab.cat/record/253660 https://dx.doi.org/urn:doi:10.1186/s12931-018-0893-x |
| Access Level: | acceso abierto |
| Palabra clave: | Asthma Airway inflammation Prostaglandin D Prostaglandin D receptor 2 |
| Sumario: | Asthma is characterised by chronic airway inflammation, airway obstruction and hyper-responsiveness. The inflammatory cascade in asthma comprises a complex interplay of genetic factors, the airway epithelium, and dysregulation of the immune response. Prostaglandin D (PGD) is a lipid mediator, predominantly released from mast cells, but also by other immune cells such as T2 cells and dendritic cells, which plays a significant role in the pathophysiology of asthma. PGD mainly exerts its biological functions via two G-protein-coupled receptors, the PGD receptor 1 (DP) and 2 (DP). The DP receptor is mainly expressed by the key cells involved in type 2 immune responses, including T2 cells, type 2 innate lymphoid cells and eosinophils. The DP receptor pathway is a novel and important therapeutic target for asthma, because increased PGD production induces significant inflammatory cell chemotaxis and degranulation via its interaction with the DP receptor. This interaction has serious consequences in the pulmonary milieu, including the release of pro-inflammatory cytokines and harmful cationic proteases, leading to tissue remodelling, mucus production, structural damage, and compromised lung function. This review will discuss the importance of the DP receptor pathway and the current understanding of its role in asthma |
|---|