RIC versus MAC UCBT in adults with AML

Nonrelapse mortality (NRM) is the first cause of treatment failure after unrelated cord blood transplantation (UCBT) following myeloablative conditioning (MAC). In the last decade, reduced-intensity conditioning (RIC) regimens have been developed with the aim of reducing NRM and allowing older patie...

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Autores: Baron, Frederic|||0000-0002-2944-3812, Ruggeri, Annalisa|||0000-0002-7261-2765, Beohou, Eric, Labopin, Myriam|||0000-0003-4514-4748, Sanz, Guillermo|||0000-0002-2767-8191, Milpied, Noel|||0000-0002-5177-014X, Michallet, Mauricette, Bacigalupo, Andrea, Blaise, Didier|||0000-0002-5684-9447, Malouf Sierra, Jorge|||0000-0001-5185-520X, Socié, Gérard|||0000-0002-2114-7533, Cornelissen, Jan J., Schmid, Christoph, Giebel, Sebastian, Gorin, Norbert-Claude, Esteve Reyner, Jordi|||0000-0002-8056-648X, Ciceri, Fabio|||0000-0003-0873-0123, Savani, Bipin|||0000-0002-3304-9965, Mohty, Mohamad|||0000-0002-7264-808X, Gluckman, Eliane, Nagler, Arnon
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:289627
Acceso en línea:https://ddd.uab.cat/record/289627
https://dx.doi.org/urn:doi:10.18632/oncotarget.9599
Access Level:acceso abierto
Palabra clave:AML
Myeloablative
Reduced-intensity
Transplantation
Unrelated cord blood
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spelling RIC versus MAC UCBT in adults with AMLA report from Eurocord, the ALWP and the CTIWP of the EBMTBaron, Frederic|||0000-0002-2944-3812Ruggeri, Annalisa|||0000-0002-7261-2765Beohou, EricLabopin, Myriam|||0000-0003-4514-4748Sanz, Guillermo|||0000-0002-2767-8191Milpied, Noel|||0000-0002-5177-014XMichallet, MauricetteBacigalupo, AndreaBlaise, Didier|||0000-0002-5684-9447Malouf Sierra, Jorge|||0000-0001-5185-520XSocié, Gérard|||0000-0002-2114-7533Cornelissen, Jan J.Schmid, ChristophGiebel, SebastianGorin, Norbert-ClaudeEsteve Reyner, Jordi|||0000-0002-8056-648XCiceri, Fabio|||0000-0003-0873-0123Savani, Bipin|||0000-0002-3304-9965Mohty, Mohamad|||0000-0002-7264-808XGluckman, ElianeNagler, ArnonAMLMyeloablativeReduced-intensityTransplantationUnrelated cord bloodNonrelapse mortality (NRM) is the first cause of treatment failure after unrelated cord blood transplantation (UCBT) following myeloablative conditioning (MAC). In the last decade, reduced-intensity conditioning (RIC) regimens have been developed with the aim of reducing NRM and allowing older patients and those with medical comorbidities to benefit from UCBT. The aim of the current retrospective study was to compare transplantation outcomes of acute myeloid leukemia (AML) patients given UCBT after either RIC or MAC. Data from 894 adults with AML receiving a single or double UCBT as first allograft from 2004 to 2013 at EBMT centers were included in this study. 415 patients were given UCBT after RIC while 479 patients following a MAC. In comparison to MAC recipients, RIC recipients had a similar incidence of neutrophil engraftment and of acute and chronic graft-versus-host disease (GVHD). However, RIC recipients had a higher incidence of disease relapse and a lower NRM, translating to comparable leukemia-free (LFS), GVHD-free, relapse-free survival (GRFS) and overall survival (OS). These observations remained qualitatively similar after adjusting for differences between groups in multivariate analyses. In conclusion, these data suggest that LFS and OS are similar with RIC or with MAC in adults AML patients transplanted with UCBT. These observations could serve as basis for a future prospective randomized study.Universitat Autònoma de Barcelona 22016-01-0120162016-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/289627https://dx.doi.org/urn:doi:10.18632/oncotarget.9599reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2896272026-06-06T12:50:31Z
dc.title.none.fl_str_mv RIC versus MAC UCBT in adults with AML
A report from Eurocord, the ALWP and the CTIWP of the EBMT
title RIC versus MAC UCBT in adults with AML
spellingShingle RIC versus MAC UCBT in adults with AML
Baron, Frederic|||0000-0002-2944-3812
AML
Myeloablative
Reduced-intensity
Transplantation
Unrelated cord blood
title_short RIC versus MAC UCBT in adults with AML
title_full RIC versus MAC UCBT in adults with AML
title_fullStr RIC versus MAC UCBT in adults with AML
title_full_unstemmed RIC versus MAC UCBT in adults with AML
title_sort RIC versus MAC UCBT in adults with AML
dc.creator.none.fl_str_mv Baron, Frederic|||0000-0002-2944-3812
Ruggeri, Annalisa|||0000-0002-7261-2765
Beohou, Eric
Labopin, Myriam|||0000-0003-4514-4748
Sanz, Guillermo|||0000-0002-2767-8191
Milpied, Noel|||0000-0002-5177-014X
Michallet, Mauricette
Bacigalupo, Andrea
Blaise, Didier|||0000-0002-5684-9447
Malouf Sierra, Jorge|||0000-0001-5185-520X
Socié, Gérard|||0000-0002-2114-7533
Cornelissen, Jan J.
Schmid, Christoph
Giebel, Sebastian
Gorin, Norbert-Claude
Esteve Reyner, Jordi|||0000-0002-8056-648X
Ciceri, Fabio|||0000-0003-0873-0123
Savani, Bipin|||0000-0002-3304-9965
Mohty, Mohamad|||0000-0002-7264-808X
Gluckman, Eliane
Nagler, Arnon
author Baron, Frederic|||0000-0002-2944-3812
author_facet Baron, Frederic|||0000-0002-2944-3812
Ruggeri, Annalisa|||0000-0002-7261-2765
Beohou, Eric
Labopin, Myriam|||0000-0003-4514-4748
Sanz, Guillermo|||0000-0002-2767-8191
Milpied, Noel|||0000-0002-5177-014X
Michallet, Mauricette
Bacigalupo, Andrea
Blaise, Didier|||0000-0002-5684-9447
Malouf Sierra, Jorge|||0000-0001-5185-520X
Socié, Gérard|||0000-0002-2114-7533
Cornelissen, Jan J.
Schmid, Christoph
Giebel, Sebastian
Gorin, Norbert-Claude
Esteve Reyner, Jordi|||0000-0002-8056-648X
Ciceri, Fabio|||0000-0003-0873-0123
Savani, Bipin|||0000-0002-3304-9965
Mohty, Mohamad|||0000-0002-7264-808X
Gluckman, Eliane
Nagler, Arnon
author_role author
author2 Ruggeri, Annalisa|||0000-0002-7261-2765
Beohou, Eric
Labopin, Myriam|||0000-0003-4514-4748
Sanz, Guillermo|||0000-0002-2767-8191
Milpied, Noel|||0000-0002-5177-014X
Michallet, Mauricette
Bacigalupo, Andrea
Blaise, Didier|||0000-0002-5684-9447
Malouf Sierra, Jorge|||0000-0001-5185-520X
Socié, Gérard|||0000-0002-2114-7533
Cornelissen, Jan J.
Schmid, Christoph
Giebel, Sebastian
Gorin, Norbert-Claude
Esteve Reyner, Jordi|||0000-0002-8056-648X
Ciceri, Fabio|||0000-0003-0873-0123
Savani, Bipin|||0000-0002-3304-9965
Mohty, Mohamad|||0000-0002-7264-808X
Gluckman, Eliane
Nagler, Arnon
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv AML
Myeloablative
Reduced-intensity
Transplantation
Unrelated cord blood
topic AML
Myeloablative
Reduced-intensity
Transplantation
Unrelated cord blood
description Nonrelapse mortality (NRM) is the first cause of treatment failure after unrelated cord blood transplantation (UCBT) following myeloablative conditioning (MAC). In the last decade, reduced-intensity conditioning (RIC) regimens have been developed with the aim of reducing NRM and allowing older patients and those with medical comorbidities to benefit from UCBT. The aim of the current retrospective study was to compare transplantation outcomes of acute myeloid leukemia (AML) patients given UCBT after either RIC or MAC. Data from 894 adults with AML receiving a single or double UCBT as first allograft from 2004 to 2013 at EBMT centers were included in this study. 415 patients were given UCBT after RIC while 479 patients following a MAC. In comparison to MAC recipients, RIC recipients had a similar incidence of neutrophil engraftment and of acute and chronic graft-versus-host disease (GVHD). However, RIC recipients had a higher incidence of disease relapse and a lower NRM, translating to comparable leukemia-free (LFS), GVHD-free, relapse-free survival (GRFS) and overall survival (OS). These observations remained qualitatively similar after adjusting for differences between groups in multivariate analyses. In conclusion, these data suggest that LFS and OS are similar with RIC or with MAC in adults AML patients transplanted with UCBT. These observations could serve as basis for a future prospective randomized study.
publishDate 2016
dc.date.none.fl_str_mv 2
2016-01-01
2016
2016-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/289627
https://dx.doi.org/urn:doi:10.18632/oncotarget.9599
url https://ddd.uab.cat/record/289627
https://dx.doi.org/urn:doi:10.18632/oncotarget.9599
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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