Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study

BACKGROUND: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, hut evidence is scarce and inconsistent. OBJECTIVES: We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic ri...

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Autores: Manzano-Salgado, Cyntia B., Casas, Maribel, Lopez-Espinosa, Maria-Jose, Ballester, Ferran, Iniguez, Carmen, Martinez, David, Romaguera, Dora, Fernandez-Barres, Silvia, Santa-Marina, Loreto, Basterretxea, Mikel, Schettgen, Thomas, Valvi, Damaskini, Vioque, Jesus, Sunyer, Jordi, Vrijheid, Martine
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/9689
Acceso en línea:https://hdl.handle.net/20.500.13003/9689
Access Level:acceso abierto
Palabra clave:Adult
Environmental Pollutants
Humans
Environmental Exposure
Fluorocarbons
Caprylates
Pregnancy
Male
Alkanesulfonic Acids
Female
Prenatal Exposure Delayed Effects
Child
Maternal Exposure
Spain
España
Exposición Materna
Femenino
Ácidos Alcanesulfónicos
Exposición a Riesgos Ambientales
Masculino
Fluorocarburos
Contaminantes Ambientales
Caprilatos
Humanos
Embarazo
Niño
Adulto
Efectos Tardíos de la Exposición Prenatal
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spelling Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort StudyManzano-Salgado, Cyntia B.Casas, MaribelLopez-Espinosa, Maria-JoseBallester, FerranIniguez, CarmenMartinez, DavidRomaguera, DoraFernandez-Barres, SilviaSanta-Marina, LoretoBasterretxea, MikelSchettgen, ThomasValvi, DamaskiniVioque, JesusSunyer, JordiVrijheid, MartineAdultEnvironmental PollutantsHumansEnvironmental ExposureFluorocarbonsCaprylatesPregnancyMaleAlkanesulfonic AcidsFemalePrenatal Exposure Delayed EffectsChildMaternal ExposureSpainEspañaExposición MaternaFemeninoÁcidos AlcanesulfónicosExposición a Riesgos AmbientalesMasculinoFluorocarburosContaminantes AmbientalesCaprilatosHumanosEmbarazoNiñoAdultoEfectos Tardíos de la Exposición PrenatalBACKGROUND: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, hut evidence is scarce and inconsistent. OBJECTIVES: We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic risk, including a composite CM risk score. METHODS: We measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in maternal plasma (first trimester). We assessed weight gain from birth until 6 mo. At 4 and 7 y, we calculated the age- and sex-specific z-scores for BMI, waist circumference (WC), and blood pressure (BP) (n approximate to 1,000). At age 4, we calculated the age-, sex-, and region specific z-scores for cholesterol, triglycerides (TGs), high-density (HDL-C), and low-density lipoprotein cholesterol (LDL-C) (n = 627). At age 4, we calculated a CM-risk score (n = 386) as the sum of the individual age-, sex-, and region-specific z-scores for WC, BP, HDL-C, and TGs. We used the average between the negative of HDE-C z-score and TGs z-score to give similar weight to lipids and the other components in the score. A higher score indicates a higher cardiometaholic risk at age 4. RESULTS: PFOS and PFOA were the most abundant PFAS (geometric mean: 5.80 and 2.32 ng/mL respectively). In general, prenatal PFAS concentrations were not associated with individual outcomes or the combined CM-risk score. Exceptions were positive associations between prenatal PFHxS and TGs z-score [for a doubling of exposure, beta = 0.11; 95% confidence interval (CI): 0.01, 0.21], and between PFNA and the CM-risk score (beta=0.60; 95% CI: 0.04, 1.16). There was not clear or consistent evidence of modification by sex. CONCLUSIONS: We observed little or no evidence of associations between low prenatal PFAS exposures and outcomes related to cardiometabolic risk in a cohort of Spanish children followed from birth until 7 y.Us Dept Health Human Sciences Public Health Science20172017-09-0120172017-09-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/9689reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/96892026-06-22T12:44:07Z
dc.title.none.fl_str_mv Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
title Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
spellingShingle Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
Manzano-Salgado, Cyntia B.
Adult
Environmental Pollutants
Humans
Environmental Exposure
Fluorocarbons
Caprylates
Pregnancy
Male
Alkanesulfonic Acids
Female
Prenatal Exposure Delayed Effects
Child
Maternal Exposure
Spain
España
Exposición Materna
Femenino
Ácidos Alcanesulfónicos
Exposición a Riesgos Ambientales
Masculino
Fluorocarburos
Contaminantes Ambientales
Caprilatos
Humanos
Embarazo
Niño
Adulto
Efectos Tardíos de la Exposición Prenatal
title_short Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
title_full Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
title_fullStr Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
title_full_unstemmed Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
title_sort Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
dc.creator.none.fl_str_mv Manzano-Salgado, Cyntia B.
Casas, Maribel
Lopez-Espinosa, Maria-Jose
Ballester, Ferran
Iniguez, Carmen
Martinez, David
Romaguera, Dora
Fernandez-Barres, Silvia
Santa-Marina, Loreto
Basterretxea, Mikel
Schettgen, Thomas
Valvi, Damaskini
Vioque, Jesus
Sunyer, Jordi
Vrijheid, Martine
author Manzano-Salgado, Cyntia B.
author_facet Manzano-Salgado, Cyntia B.
Casas, Maribel
Lopez-Espinosa, Maria-Jose
Ballester, Ferran
Iniguez, Carmen
Martinez, David
Romaguera, Dora
Fernandez-Barres, Silvia
Santa-Marina, Loreto
Basterretxea, Mikel
Schettgen, Thomas
Valvi, Damaskini
Vioque, Jesus
Sunyer, Jordi
Vrijheid, Martine
author_role author
author2 Casas, Maribel
Lopez-Espinosa, Maria-Jose
Ballester, Ferran
Iniguez, Carmen
Martinez, David
Romaguera, Dora
Fernandez-Barres, Silvia
Santa-Marina, Loreto
Basterretxea, Mikel
Schettgen, Thomas
Valvi, Damaskini
Vioque, Jesus
Sunyer, Jordi
Vrijheid, Martine
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Adult
Environmental Pollutants
Humans
Environmental Exposure
Fluorocarbons
Caprylates
Pregnancy
Male
Alkanesulfonic Acids
Female
Prenatal Exposure Delayed Effects
Child
Maternal Exposure
Spain
España
Exposición Materna
Femenino
Ácidos Alcanesulfónicos
Exposición a Riesgos Ambientales
Masculino
Fluorocarburos
Contaminantes Ambientales
Caprilatos
Humanos
Embarazo
Niño
Adulto
Efectos Tardíos de la Exposición Prenatal
topic Adult
Environmental Pollutants
Humans
Environmental Exposure
Fluorocarbons
Caprylates
Pregnancy
Male
Alkanesulfonic Acids
Female
Prenatal Exposure Delayed Effects
Child
Maternal Exposure
Spain
España
Exposición Materna
Femenino
Ácidos Alcanesulfónicos
Exposición a Riesgos Ambientales
Masculino
Fluorocarburos
Contaminantes Ambientales
Caprilatos
Humanos
Embarazo
Niño
Adulto
Efectos Tardíos de la Exposición Prenatal
description BACKGROUND: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, hut evidence is scarce and inconsistent. OBJECTIVES: We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic risk, including a composite CM risk score. METHODS: We measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in maternal plasma (first trimester). We assessed weight gain from birth until 6 mo. At 4 and 7 y, we calculated the age- and sex-specific z-scores for BMI, waist circumference (WC), and blood pressure (BP) (n approximate to 1,000). At age 4, we calculated the age-, sex-, and region specific z-scores for cholesterol, triglycerides (TGs), high-density (HDL-C), and low-density lipoprotein cholesterol (LDL-C) (n = 627). At age 4, we calculated a CM-risk score (n = 386) as the sum of the individual age-, sex-, and region-specific z-scores for WC, BP, HDL-C, and TGs. We used the average between the negative of HDE-C z-score and TGs z-score to give similar weight to lipids and the other components in the score. A higher score indicates a higher cardiometaholic risk at age 4. RESULTS: PFOS and PFOA were the most abundant PFAS (geometric mean: 5.80 and 2.32 ng/mL respectively). In general, prenatal PFAS concentrations were not associated with individual outcomes or the combined CM-risk score. Exceptions were positive associations between prenatal PFHxS and TGs z-score [for a doubling of exposure, beta = 0.11; 95% confidence interval (CI): 0.01, 0.21], and between PFNA and the CM-risk score (beta=0.60; 95% CI: 0.04, 1.16). There was not clear or consistent evidence of modification by sex. CONCLUSIONS: We observed little or no evidence of associations between low prenatal PFAS exposures and outcomes related to cardiometabolic risk in a cohort of Spanish children followed from birth until 7 y.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-09-01
2017
2017-09-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/9689
url https://hdl.handle.net/20.500.13003/9689
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Us Dept Health Human Sciences Public Health Science
publisher.none.fl_str_mv Us Dept Health Human Sciences Public Health Science
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414317676298240
score 15,812429

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