Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota

Read-only version at https://rdcu.be/chxsS.-- The final publication is available at http://link.springer.com

Detalles Bibliográficos
Autores: Selma Royo, Marta, García Mantrana, Izaskun, Calatayud Arroyo, Marta, Parra Llorca, Anna, Martínez Costa, C., Collado, María Carmen
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/218764
Acceso en línea:http://hdl.handle.net/10261/218764
Access Level:acceso abierto
Palabra clave:Maternal diet
Intestinal permeability
Microbiota
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spelling Maternal diet during pregnancy and intestinal markers are associated with early gut microbiotaSelma Royo, MartaGarcía Mantrana, IzaskunCalatayud Arroyo, MartaParra Llorca, AnnaMartínez Costa, C.Collado, María CarmenMaternal dietIntestinal permeabilityMicrobiotaRead-only version at https://rdcu.be/chxsS.-- The final publication is available at http://link.springer.comBackground: Diet has an important role in host–microbiome interplay, which may result in intestinal permeability changes and physiopathological effects at a systemic level. Despite the importance of maternal microbiota as the main contributor to the initial microbial seeding, little is known about the effects of maternal diet during pregnancy on maternal-neonatal microbiota. Objectives: This study aimed at ascertaining the possible associations between maternal dietary intake during pregnancy and neonatal microbiota at birth and to evaluate the relationship with maternal intestinal markers. Methods: In a nested cross-sectional study in the longitudinal MAMI cohort, maternal-neonatal microbiota profiling at birth (n = 73) was assessed by 16S rRNA gene sequencing. Maternal intestinal markers as zonulin, intestinal alkaline phosphatase (IAP) activity and faecal calprotectin were measured in faeces. Furthermore, maternal-neonatal clinical and anthropometric data, as well as maternal nutrient intake during pregnancy obtained by FFQ questionnaires, were collected. Results: Maternal diet is associated with both maternal and neonatal microbiota at the time of birth, in a delivery mode-dependent manner. The existing link between maternal diet, intestinal makers and neonatal gut microbiota would be mainly influenced by the intake of saturated (SFA) and monounsaturated fatty acids (MUFA). Members of Firmicutes in the neonatal microbiota were positively associated with maternal fat intake, especially SFA and MUFA, and negatively correlated to fibre, proteins from vegetable sources and vitamins. Conclusions: Maternal diet during pregnancy, mainly fat intake (SFA and MUFA), was related to intestinal markers, thus likely shifting the microbial transmission to the neonate and priming the neonatal microbial profile with potential health outcomes. Clinical trial registry: NCT03552939The study was financially supported by European Research Council under the European Union's Horizon 2020 research and innovation program (ERC starting grant, n° 639226). M.S-R. is supported by a Predoctoral Fellowship from Generalitat Valenciana-European Social Fund (ASCII2016).Peer reviewedSpringer NatureEuropean CommissionGeneralitat ValencianaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/218764reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/639226https://doi.org/10.1007/s00394-020-02337-7Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2187642026-05-22T06:33:51Z
dc.title.none.fl_str_mv Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
title Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
spellingShingle Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
Selma Royo, Marta
Maternal diet
Intestinal permeability
Microbiota
title_short Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
title_full Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
title_fullStr Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
title_full_unstemmed Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
title_sort Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
dc.creator.none.fl_str_mv Selma Royo, Marta
García Mantrana, Izaskun
Calatayud Arroyo, Marta
Parra Llorca, Anna
Martínez Costa, C.
Collado, María Carmen
author Selma Royo, Marta
author_facet Selma Royo, Marta
García Mantrana, Izaskun
Calatayud Arroyo, Marta
Parra Llorca, Anna
Martínez Costa, C.
Collado, María Carmen
author_role author
author2 García Mantrana, Izaskun
Calatayud Arroyo, Marta
Parra Llorca, Anna
Martínez Costa, C.
Collado, María Carmen
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Generalitat Valenciana
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Maternal diet
Intestinal permeability
Microbiota
topic Maternal diet
Intestinal permeability
Microbiota
description Read-only version at https://rdcu.be/chxsS.-- The final publication is available at http://link.springer.com
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/218764
url http://hdl.handle.net/10261/218764
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/639226
https://doi.org/10.1007/s00394-020-02337-7
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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