Epigenetic clocks in relapse after a first episode of schizophrenia

The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methy...

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Detalles Bibliográficos
Autores: Segura À.-G., Prohens L., Mezquida G., Amoretti S., Bioque M., Ribeiro M., Gurriarán-Bas X., Rementería L., Berge D., Rodriguez-Jimenez R., Roldán A., Pomarol-Clotet E., Ibáñez A., Usall J., García-Portilla M.P., Cuesta M.J., Parellada M., González-Pinto A., Berrocoso E., Bernardo M., Mas S., González-Díaz J.M., Arbelo N., González-Peñas J., Pina-Camacho L., Diestre A., Selma J., Zorrilla I., López P., Trabsa A., Monserrat C., Sanchez-Pastor L., Nuñez-Doyle A., Fatjó-Vilas M., Sarró S., Butjosa A., Pardo M., López-Ilundain J.M., Sánchez Torres A.M., Saiz-Ruiz J., Ochoa-Mangado E., RIevero O., De-la-Cámara C., Echevarría R.S., González-Blanco L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p15376
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15376
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85134561397&doi=10.1038%2fs41537-022-00268-2&partnerID=40&md5=6f41c5a6573244c93946cd58c55497f6
Access Level:acceso abierto
Palabra clave:adult
aging
Article
cognition
cohort analysis
controlled study
DNA methylation
epigenetic clock
female
follow up
human
human cell
major clinical study
male
mental performance
mortality
relapse
remission
schizophrenia
telomere length
working memory
Descripción
Sumario:The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p = 0.030). Shorter telomere length was associated with cognitive performance (working memory, r = 0.31 p = 0.015; verbal fluency, r = 0.28 p = 0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages. © 2022, The Author(s).

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