Spontaneous parkinsonism is associated with cognitive impairment in antipsychotic-naive patients with first-episode psychosis: a 6-month follow-up study

There is now growing evidence that parkinsonism and other extrapyramidal signs are highly prevalent in patients with first-episode psychosis who have never been exposed to antipsychotic drugs. However, the neurocognitive correlates of parkinsonism in this population remained to be clarified. A sampl...

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Autores: Cuesta, Manuel J., Sánchez Torres, Ana María, García de Jalón, Elena, Campos, María S., Ibáñez Beroiz, Berta, Moreno-Izco, Lucía, Peralta Martín, Víctor
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/47319
Acceso en línea:https://hdl.handle.net/2454/47319
Access Level:acceso abierto
Palabra clave:Schizophrenia
Neuropsychological impairment
Cognition
Extrapyramidal signs
Abnormal movements
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spelling Spontaneous parkinsonism is associated with cognitive impairment in antipsychotic-naive patients with first-episode psychosis: a 6-month follow-up studyCuesta, Manuel J.Sánchez Torres, Ana MaríaGarcía de Jalón, ElenaCampos, María S.Ibáñez Beroiz, BertaMoreno-Izco, LucíaPeralta Martín, VíctorSchizophreniaNeuropsychological impairmentCognitionExtrapyramidal signsAbnormal movementsThere is now growing evidence that parkinsonism and other extrapyramidal signs are highly prevalent in patients with first-episode psychosis who have never been exposed to antipsychotic drugs. However, the neurocognitive correlates of parkinsonism in this population remained to be clarified. A sample comprising 100 consecutive drug-naive patients with first-episode psychosis were enrolled on the study and followed up for 6 months. Seventy-seven completed assessments at 3 time points (baseline, 1 mo, and 6 mo), involving clinical and cognitive examinations and a specific assessment of motor abnormalities. The Simpson-Angus Scale (SAS) was used for the assessment of extrapyramidal signs, and each motor domain was evaluated with a standard assessment scale. Linear mixed models were built to explore the longitudinal relationships between parkinsonism scores and cognitive impairment. Parkinsonism scores showed significant strong longitudinal associations with deficits in memory, executive functioning, and attention. Spontaneous parkinsonism (total SAS score and hypokinesia and rigidity subscores at baseline) showed high 6-month predictive values for cognitive impairment. In addition, they also had high predictive values for neurologic soft-sign abnormalities but not for dyskinesia, akathisia, and pure catatonic abnormalities. No predictive value was found for glabella-salivation or tremor subscores on the SAS scale. These results emphasize the relevance of the assessment of parkinsonism signs prior to starting to administer antipsychotic drugs, as core manifestations of psychotic illness with a high predictive value for cognitive impairment.Department of Health of the Government of Navarra (55/2007, 11/101); Carlos III Health Institute (Fondo Europeo de Desarrollo Regional Funds) from the Spanish Ministry of Economy and Competitivity (08/I/1026); Spanish Ministry of Science and Innovation (SAF2008-05674-C03-02).Oxford University PressCiencias de la SaludOsasun Zientziak2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/mswordhttps://hdl.handle.net/2454/47319reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/MINECO//08%2FI%2F1026info:eu-repo/grantAgreement/MICINN//SAF2008-05674-C03-02info:eu-repo/grantAgreement/Gobierno de Navarra//55%2F2007info:eu-repo/grantAgreement/Gobierno de Navarra//11%2F101© The Author 2013. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/473192026-06-17T12:41:47Z
dc.title.none.fl_str_mv Spontaneous parkinsonism is associated with cognitive impairment in antipsychotic-naive patients with first-episode psychosis: a 6-month follow-up study
title Spontaneous parkinsonism is associated with cognitive impairment in antipsychotic-naive patients with first-episode psychosis: a 6-month follow-up study
spellingShingle Spontaneous parkinsonism is associated with cognitive impairment in antipsychotic-naive patients with first-episode psychosis: a 6-month follow-up study
Cuesta, Manuel J.
Schizophrenia
Neuropsychological impairment
Cognition
Extrapyramidal signs
Abnormal movements
title_short Spontaneous parkinsonism is associated with cognitive impairment in antipsychotic-naive patients with first-episode psychosis: a 6-month follow-up study
title_full Spontaneous parkinsonism is associated with cognitive impairment in antipsychotic-naive patients with first-episode psychosis: a 6-month follow-up study
title_fullStr Spontaneous parkinsonism is associated with cognitive impairment in antipsychotic-naive patients with first-episode psychosis: a 6-month follow-up study
title_full_unstemmed Spontaneous parkinsonism is associated with cognitive impairment in antipsychotic-naive patients with first-episode psychosis: a 6-month follow-up study
title_sort Spontaneous parkinsonism is associated with cognitive impairment in antipsychotic-naive patients with first-episode psychosis: a 6-month follow-up study
dc.creator.none.fl_str_mv Cuesta, Manuel J.
Sánchez Torres, Ana María
García de Jalón, Elena
Campos, María S.
Ibáñez Beroiz, Berta
Moreno-Izco, Lucía
Peralta Martín, Víctor
author Cuesta, Manuel J.
author_facet Cuesta, Manuel J.
Sánchez Torres, Ana María
García de Jalón, Elena
Campos, María S.
Ibáñez Beroiz, Berta
Moreno-Izco, Lucía
Peralta Martín, Víctor
author_role author
author2 Sánchez Torres, Ana María
García de Jalón, Elena
Campos, María S.
Ibáñez Beroiz, Berta
Moreno-Izco, Lucía
Peralta Martín, Víctor
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
dc.subject.none.fl_str_mv Schizophrenia
Neuropsychological impairment
Cognition
Extrapyramidal signs
Abnormal movements
topic Schizophrenia
Neuropsychological impairment
Cognition
Extrapyramidal signs
Abnormal movements
description There is now growing evidence that parkinsonism and other extrapyramidal signs are highly prevalent in patients with first-episode psychosis who have never been exposed to antipsychotic drugs. However, the neurocognitive correlates of parkinsonism in this population remained to be clarified. A sample comprising 100 consecutive drug-naive patients with first-episode psychosis were enrolled on the study and followed up for 6 months. Seventy-seven completed assessments at 3 time points (baseline, 1 mo, and 6 mo), involving clinical and cognitive examinations and a specific assessment of motor abnormalities. The Simpson-Angus Scale (SAS) was used for the assessment of extrapyramidal signs, and each motor domain was evaluated with a standard assessment scale. Linear mixed models were built to explore the longitudinal relationships between parkinsonism scores and cognitive impairment. Parkinsonism scores showed significant strong longitudinal associations with deficits in memory, executive functioning, and attention. Spontaneous parkinsonism (total SAS score and hypokinesia and rigidity subscores at baseline) showed high 6-month predictive values for cognitive impairment. In addition, they also had high predictive values for neurologic soft-sign abnormalities but not for dyskinesia, akathisia, and pure catatonic abnormalities. No predictive value was found for glabella-salivation or tremor subscores on the SAS scale. These results emphasize the relevance of the assessment of parkinsonism signs prior to starting to administer antipsychotic drugs, as core manifestations of psychotic illness with a high predictive value for cognitive impairment.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/47319
url https://hdl.handle.net/2454/47319
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO//08%2FI%2F1026
info:eu-repo/grantAgreement/MICINN//SAF2008-05674-C03-02
info:eu-repo/grantAgreement/Gobierno de Navarra//55%2F2007
info:eu-repo/grantAgreement/Gobierno de Navarra//11%2F101
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/msword
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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