Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells

Santisteban-Eslava, M. (Marta)|||/items/563d2cef-8a22-4110-97f4-8e16eac15419; Reiman, J.M. (Jennifer M.)|||/items/429b10fa-3b70-4ad7-a2fa-9ad48c110300; Asiedu, M.K. (Michael K.)|||/items/4c131ec4-56c9-4a6d-8643-8446231d3548; Behrens, M.D. (Marshall D.)|||/items/fbb13757-ec83-4ae3-a08a-59dfca11d93d; Nassar, A. (Aziza)|||/items/92cbd32d-7327-4a60-bc37-6c306df9d414; Kalli, K.R. (Kimberly R.)|||/items/e8854046-0ec3-43ce-8df6-ff89f4a91352; Haluska, P. (Paul)|||/items/2c2e0a2c-1cbf-4c8d-9e4c-2d3368ca5114; Ingle, J.N. (James N.)|||/items/d7cdceca-6cc0-4fc3-83e0-37bb20369cd9; Hartmann, L.C. (Lynn C.)|||/items/6105fd75-58d1-424b-b4ad-4c3fe8a411a3; Manjili, M.H. (Masoud H.)|||/items/fbd76136-bcab-4378-be8a-7cb8ef5f087d; Radisky, D.C. (Derek C.)|||/items/d32a50a1-179b-4136-b290-ff8a044cc938; Ferrone, S. (Soldano)|||/items/c7d87af0-c01e-4f02-8d2e-6f6facd9e2f0; Knutson, K.L. (Keith L.)|||/items/fa5d1fc5-473c-4a89-9581-569e78ee8d27

Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells

The breast cancer stem cell (BCSC) hypotheses suggest that breast cancer is derived from a single tumor-initiating cell with stem-like properties, but the source of these cells is unclear. We previously observed that induction of an immune response against an epithelial breast cancer led in vivo to...

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Detalles Bibliográficos
Autores:	Santisteban-Eslava, M. (Marta)\|\|\|/items/563d2cef-8a22-4110-97f4-8e16eac15419, Reiman, J.M. (Jennifer M.)\|\|\|/items/429b10fa-3b70-4ad7-a2fa-9ad48c110300, Asiedu, M.K. (Michael K.)\|\|\|/items/4c131ec4-56c9-4a6d-8643-8446231d3548, Behrens, M.D. (Marshall D.)\|\|\|/items/fbb13757-ec83-4ae3-a08a-59dfca11d93d, Nassar, A. (Aziza)\|\|\|/items/92cbd32d-7327-4a60-bc37-6c306df9d414, Kalli, K.R. (Kimberly R.)\|\|\|/items/e8854046-0ec3-43ce-8df6-ff89f4a91352, Haluska, P. (Paul)\|\|\|/items/2c2e0a2c-1cbf-4c8d-9e4c-2d3368ca5114, Ingle, J.N. (James N.)\|\|\|/items/d7cdceca-6cc0-4fc3-83e0-37bb20369cd9, Hartmann, L.C. (Lynn C.)\|\|\|/items/6105fd75-58d1-424b-b4ad-4c3fe8a411a3, Manjili, M.H. (Masoud H.)\|\|\|/items/fbd76136-bcab-4378-be8a-7cb8ef5f087d, Radisky, D.C. (Derek C.)\|\|\|/items/d32a50a1-179b-4136-b290-ff8a044cc938, Ferrone, S. (Soldano)\|\|\|/items/c7d87af0-c01e-4f02-8d2e-6f6facd9e2f0, Knutson, K.L. (Keith L.)\|\|\|/items/fa5d1fc5-473c-4a89-9581-569e78ee8d27
Tipo de recurso:	artículo
Fecha de publicación:	2009
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/36321
Acceso en línea:	https://hdl.handle.net/10171/36321
Access Level:	acceso abierto
Palabra clave:	Mammary neoplasms Epithelial cells Antigens, CD24 Antigens, CD44

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spelling	Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cellsSantisteban-Eslava, M. (Marta)\|\|\|/items/563d2cef-8a22-4110-97f4-8e16eac15419Reiman, J.M. (Jennifer M.)\|\|\|/items/429b10fa-3b70-4ad7-a2fa-9ad48c110300Asiedu, M.K. (Michael K.)\|\|\|/items/4c131ec4-56c9-4a6d-8643-8446231d3548Behrens, M.D. (Marshall D.)\|\|\|/items/fbb13757-ec83-4ae3-a08a-59dfca11d93dNassar, A. (Aziza)\|\|\|/items/92cbd32d-7327-4a60-bc37-6c306df9d414Kalli, K.R. (Kimberly R.)\|\|\|/items/e8854046-0ec3-43ce-8df6-ff89f4a91352Haluska, P. (Paul)\|\|\|/items/2c2e0a2c-1cbf-4c8d-9e4c-2d3368ca5114Ingle, J.N. (James N.)\|\|\|/items/d7cdceca-6cc0-4fc3-83e0-37bb20369cd9Hartmann, L.C. (Lynn C.)\|\|\|/items/6105fd75-58d1-424b-b4ad-4c3fe8a411a3Manjili, M.H. (Masoud H.)\|\|\|/items/fbd76136-bcab-4378-be8a-7cb8ef5f087dRadisky, D.C. (Derek C.)\|\|\|/items/d32a50a1-179b-4136-b290-ff8a044cc938Ferrone, S. (Soldano)\|\|\|/items/c7d87af0-c01e-4f02-8d2e-6f6facd9e2f0Knutson, K.L. (Keith L.)\|\|\|/items/fa5d1fc5-473c-4a89-9581-569e78ee8d27Mammary neoplasmsEpithelial cellsAntigens, CD24Antigens, CD44The breast cancer stem cell (BCSC) hypotheses suggest that breast cancer is derived from a single tumor-initiating cell with stem-like properties, but the source of these cells is unclear. We previously observed that induction of an immune response against an epithelial breast cancer led in vivo to the T-cell-dependent outgrowth of a tumor, the cells of which had undergone epithelial to mesenchymal transition (EMT). The resulting mesenchymal tumor cells had a CD24(-/lo)CD44(+) phenotype, consistent with BCSCs. In the present study, we found that EMT was induced by CD8 T cells and the resulting tumors had characteristics of BCSCs, including potent tumorigenicity, ability to reestablish an epithelial tumor, and enhanced resistance to drugs and radiation. In contrast to the hierarchal cancer stem cell hypothesis, which suggests that breast cancer arises from the transformation of a resident tissue stem cell, our results show that EMT can produce the BCSC phenotype. These findings have several important implications related to disease progression and relapse.American Association for Cancer ResearchDadun. Depósito Académico Digital Universidad de Navarra20142014-08-1220092009-04-0120092009-04-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/36321reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/363212026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
title	Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
spellingShingle	Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells Santisteban-Eslava, M. (Marta)\|\|\|/items/563d2cef-8a22-4110-97f4-8e16eac15419 Mammary neoplasms Epithelial cells Antigens, CD24 Antigens, CD44
title_short	Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
title_full	Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
title_fullStr	Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
title_full_unstemmed	Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
title_sort	Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
dc.creator.none.fl_str_mv	Santisteban-Eslava, M. (Marta)\|\|\|/items/563d2cef-8a22-4110-97f4-8e16eac15419 Reiman, J.M. (Jennifer M.)\|\|\|/items/429b10fa-3b70-4ad7-a2fa-9ad48c110300 Asiedu, M.K. (Michael K.)\|\|\|/items/4c131ec4-56c9-4a6d-8643-8446231d3548 Behrens, M.D. (Marshall D.)\|\|\|/items/fbb13757-ec83-4ae3-a08a-59dfca11d93d Nassar, A. (Aziza)\|\|\|/items/92cbd32d-7327-4a60-bc37-6c306df9d414 Kalli, K.R. (Kimberly R.)\|\|\|/items/e8854046-0ec3-43ce-8df6-ff89f4a91352 Haluska, P. (Paul)\|\|\|/items/2c2e0a2c-1cbf-4c8d-9e4c-2d3368ca5114 Ingle, J.N. (James N.)\|\|\|/items/d7cdceca-6cc0-4fc3-83e0-37bb20369cd9 Hartmann, L.C. (Lynn C.)\|\|\|/items/6105fd75-58d1-424b-b4ad-4c3fe8a411a3 Manjili, M.H. (Masoud H.)\|\|\|/items/fbd76136-bcab-4378-be8a-7cb8ef5f087d Radisky, D.C. (Derek C.)\|\|\|/items/d32a50a1-179b-4136-b290-ff8a044cc938 Ferrone, S. (Soldano)\|\|\|/items/c7d87af0-c01e-4f02-8d2e-6f6facd9e2f0 Knutson, K.L. (Keith L.)\|\|\|/items/fa5d1fc5-473c-4a89-9581-569e78ee8d27
author	Santisteban-Eslava, M. (Marta)\|\|\|/items/563d2cef-8a22-4110-97f4-8e16eac15419
author_facet	Santisteban-Eslava, M. (Marta)\|\|\|/items/563d2cef-8a22-4110-97f4-8e16eac15419 Reiman, J.M. (Jennifer M.)\|\|\|/items/429b10fa-3b70-4ad7-a2fa-9ad48c110300 Asiedu, M.K. (Michael K.)\|\|\|/items/4c131ec4-56c9-4a6d-8643-8446231d3548 Behrens, M.D. (Marshall D.)\|\|\|/items/fbb13757-ec83-4ae3-a08a-59dfca11d93d Nassar, A. (Aziza)\|\|\|/items/92cbd32d-7327-4a60-bc37-6c306df9d414 Kalli, K.R. (Kimberly R.)\|\|\|/items/e8854046-0ec3-43ce-8df6-ff89f4a91352 Haluska, P. (Paul)\|\|\|/items/2c2e0a2c-1cbf-4c8d-9e4c-2d3368ca5114 Ingle, J.N. (James N.)\|\|\|/items/d7cdceca-6cc0-4fc3-83e0-37bb20369cd9 Hartmann, L.C. (Lynn C.)\|\|\|/items/6105fd75-58d1-424b-b4ad-4c3fe8a411a3 Manjili, M.H. (Masoud H.)\|\|\|/items/fbd76136-bcab-4378-be8a-7cb8ef5f087d Radisky, D.C. (Derek C.)\|\|\|/items/d32a50a1-179b-4136-b290-ff8a044cc938 Ferrone, S. (Soldano)\|\|\|/items/c7d87af0-c01e-4f02-8d2e-6f6facd9e2f0 Knutson, K.L. (Keith L.)\|\|\|/items/fa5d1fc5-473c-4a89-9581-569e78ee8d27
author_role	author
author2	Reiman, J.M. (Jennifer M.)\|\|\|/items/429b10fa-3b70-4ad7-a2fa-9ad48c110300 Asiedu, M.K. (Michael K.)\|\|\|/items/4c131ec4-56c9-4a6d-8643-8446231d3548 Behrens, M.D. (Marshall D.)\|\|\|/items/fbb13757-ec83-4ae3-a08a-59dfca11d93d Nassar, A. (Aziza)\|\|\|/items/92cbd32d-7327-4a60-bc37-6c306df9d414 Kalli, K.R. (Kimberly R.)\|\|\|/items/e8854046-0ec3-43ce-8df6-ff89f4a91352 Haluska, P. (Paul)\|\|\|/items/2c2e0a2c-1cbf-4c8d-9e4c-2d3368ca5114 Ingle, J.N. (James N.)\|\|\|/items/d7cdceca-6cc0-4fc3-83e0-37bb20369cd9 Hartmann, L.C. (Lynn C.)\|\|\|/items/6105fd75-58d1-424b-b4ad-4c3fe8a411a3 Manjili, M.H. (Masoud H.)\|\|\|/items/fbd76136-bcab-4378-be8a-7cb8ef5f087d Radisky, D.C. (Derek C.)\|\|\|/items/d32a50a1-179b-4136-b290-ff8a044cc938 Ferrone, S. (Soldano)\|\|\|/items/c7d87af0-c01e-4f02-8d2e-6f6facd9e2f0 Knutson, K.L. (Keith L.)\|\|\|/items/fa5d1fc5-473c-4a89-9581-569e78ee8d27
author2_role	author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Mammary neoplasms Epithelial cells Antigens, CD24 Antigens, CD44
topic	Mammary neoplasms Epithelial cells Antigens, CD24 Antigens, CD44
description	The breast cancer stem cell (BCSC) hypotheses suggest that breast cancer is derived from a single tumor-initiating cell with stem-like properties, but the source of these cells is unclear. We previously observed that induction of an immune response against an epithelial breast cancer led in vivo to the T-cell-dependent outgrowth of a tumor, the cells of which had undergone epithelial to mesenchymal transition (EMT). The resulting mesenchymal tumor cells had a CD24(-/lo)CD44(+) phenotype, consistent with BCSCs. In the present study, we found that EMT was induced by CD8 T cells and the resulting tumors had characteristics of BCSCs, including potent tumorigenicity, ability to reestablish an epithelial tumor, and enhanced resistance to drugs and radiation. In contrast to the hierarchal cancer stem cell hypothesis, which suggests that breast cancer arises from the transformation of a resident tissue stem cell, our results show that EMT can produce the BCSC phenotype. These findings have several important implications related to disease progression and relapse.
publishDate	2009
dc.date.none.fl_str_mv	2009 2009-04-01 2009 2009-04-01 2014 2014-08-12
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/36321
url	https://hdl.handle.net/10171/36321
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	American Association for Cancer Research
publisher.none.fl_str_mv	American Association for Cancer Research
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells

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