Mathematical analysis of desensitization of G protein-coupled receptors
G protein-coupled receptors are integral membrane proteins responsible for signal transduction from outside to inside the cell, and the study of their functional conditions may determine the healthy or pathological state of living organisms. In this work, four different models of increasing complexi...
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| Tipo de recurso: | tesis de maestría |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/349592 |
| Acceso en línea: | https://hdl.handle.net/2117/349592 |
| Access Level: | acceso abierto |
| Palabra clave: | Differential equations G protein-coupled receptors Desensitization GPCR signal transduction Mathe-matical Modelling Ordinary Differential Equations Equacions diferencials ordinàries Classificació AMS::34 Ordinary differential equations::34C Qualitative theory Àrees temàtiques de la UPC::Matemàtiques i estadística::Equacions diferencials i integrals::Equacions diferencials ordinàries |
| Sumario: | G protein-coupled receptors are integral membrane proteins responsible for signal transduction from outside to inside the cell, and the study of their functional conditions may determine the healthy or pathological state of living organisms. In this work, four different models of increasing complexity for the binding and function of G protein-coupled receptors have been examined. Nonlinear systems of ordinary differential equations have been studied under two different conditions: ligand excess, where the ligand is in high concentrations with respect to the receptor, and ligand depletion, where there is no assumption between the concentrations of ligand and receptor. Analytical solutions have been obtained and analyzed in the ligand excess study case, while a qualitative approach to comprehend the dynamics has been the path chosen to study the ligand depletion scenario. |
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