Ex Vivo Tracking of Endogenous CO with a Ruthenium(II) Complex

[EN] A two-photon fluorescent probe based on a ruthenium(II) vinyl complex is capable of selectively detecting carbon monoxide in cells and ex vivo using mice with a subcutaneous air pouch as a model for inflammation. This probe combines highly selective and sensitive ex vivo detection of endogenous...

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Detalles Bibliográficos
Autores: De La Torre-Paredes, Cristina, Toscani, Anita, Marín-Hernández, Cristina, Robson, Jonathan A., Terencio, M. Carmen, White, Andrew J.P., Alcaraz, M. José, Wilton-Ely, James D.E.T., Martínez-Máñez, Ramón|||0000-0001-5873-9674, Sancenón Galarza, Félix|||0000-0002-5205-7135
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/148899
Acceso en línea:https://riunet.upv.es/handle/10251/148899
Access Level:acceso abierto
Palabra clave:Carbon-Monoxide
Living cells
Fluorescent-Probe
Selective detection
Fluorogenic probes
Heme Oxygenase-1
Carbonylation
Air
QUIMICA INORGANICA
QUIMICA ORGANICA
QUIMICA ANALITICA
Descripción
Sumario:[EN] A two-photon fluorescent probe based on a ruthenium(II) vinyl complex is capable of selectively detecting carbon monoxide in cells and ex vivo using mice with a subcutaneous air pouch as a model for inflammation. This probe combines highly selective and sensitive ex vivo detection of endogenous CO in a realistic model with facile, inexpensive synthesis, and displays many advantages over the widely used palladium-based systems.

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