Development of a multi-class method for the identification and quantification of residues of antibiotics, coccidiostats and corticosteroids in milk by liquid chromatography–tandem mass spectrometry

Even if coccidiostats are not generally employed in dairy cows, maximum levels for these substances in milk samples have been set up in Commission Regulation 124/2009. Due to public health concerns regarding the presence of veterinary drug residues in milk, the aim of the present work is to report a...

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Detalles Bibliográficos
Autores: Nebot García, Carolina, Iglesias, A., Regal López, Patricia, Miranda López, José Manuel, Cepeda Sáez, Alberto, Fente Sampayo, Cristina Asunción
Tipo de recurso: artículo
Fecha de publicación:2012
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/45558
Acceso en línea:https://hdl.handle.net/10347/45558
Access Level:acceso abierto
Palabra clave:multi-class
residues
coccidiostats
veterinary drugs
milk
LC–MS/MS
657/2002/EC
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spelling Development of a multi-class method for the identification and quantification of residues of antibiotics, coccidiostats and corticosteroids in milk by liquid chromatography–tandem mass spectrometryNebot García, CarolinaIglesias, A.Regal López, PatriciaMiranda López, José ManuelCepeda Sáez, AlbertoFente Sampayo, Cristina Asunciónmulti-classresiduescoccidiostatsveterinary drugsmilkLC–MS/MS657/2002/ECEven if coccidiostats are not generally employed in dairy cows, maximum levels for these substances in milk samples have been set up in Commission Regulation 124/2009. Due to public health concerns regarding the presence of veterinary drug residues in milk, the aim of the present work is to report a multi-class high performance liquid chromatography–tandem mass spectrometry method for the simultaneous extraction, identification and quantification of seven coccidiostats, seven antimicrobial agents, three corticosteroids and an antifungal agent. Validation was conducted following the guidelines established in the European Commission Decision 2002/657/CE at the maximum concentration permitted in milk by the European Union for each drug. The method was successfully applied in 100 raw milk samples collected from ten local dairy farms and 15 milk samples bought in supermarkets. This method could be applied in routine analysis of milk samples by the dairy industry, replacing the current, non-differentiating, screening method.ElsevierUniversidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía20122012-01-0120122012-01-01journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/45558reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/455582026-06-15T12:47:27Z
dc.title.none.fl_str_mv Development of a multi-class method for the identification and quantification of residues of antibiotics, coccidiostats and corticosteroids in milk by liquid chromatography–tandem mass spectrometry
title Development of a multi-class method for the identification and quantification of residues of antibiotics, coccidiostats and corticosteroids in milk by liquid chromatography–tandem mass spectrometry
spellingShingle Development of a multi-class method for the identification and quantification of residues of antibiotics, coccidiostats and corticosteroids in milk by liquid chromatography–tandem mass spectrometry
Nebot García, Carolina
multi-class
residues
coccidiostats
veterinary drugs
milk
LC–MS/MS
657/2002/EC
title_short Development of a multi-class method for the identification and quantification of residues of antibiotics, coccidiostats and corticosteroids in milk by liquid chromatography–tandem mass spectrometry
title_full Development of a multi-class method for the identification and quantification of residues of antibiotics, coccidiostats and corticosteroids in milk by liquid chromatography–tandem mass spectrometry
title_fullStr Development of a multi-class method for the identification and quantification of residues of antibiotics, coccidiostats and corticosteroids in milk by liquid chromatography–tandem mass spectrometry
title_full_unstemmed Development of a multi-class method for the identification and quantification of residues of antibiotics, coccidiostats and corticosteroids in milk by liquid chromatography–tandem mass spectrometry
title_sort Development of a multi-class method for the identification and quantification of residues of antibiotics, coccidiostats and corticosteroids in milk by liquid chromatography–tandem mass spectrometry
dc.creator.none.fl_str_mv Nebot García, Carolina
Iglesias, A.
Regal López, Patricia
Miranda López, José Manuel
Cepeda Sáez, Alberto
Fente Sampayo, Cristina Asunción
author Nebot García, Carolina
author_facet Nebot García, Carolina
Iglesias, A.
Regal López, Patricia
Miranda López, José Manuel
Cepeda Sáez, Alberto
Fente Sampayo, Cristina Asunción
author_role author
author2 Iglesias, A.
Regal López, Patricia
Miranda López, José Manuel
Cepeda Sáez, Alberto
Fente Sampayo, Cristina Asunción
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía
dc.subject.none.fl_str_mv multi-class
residues
coccidiostats
veterinary drugs
milk
LC–MS/MS
657/2002/EC
topic multi-class
residues
coccidiostats
veterinary drugs
milk
LC–MS/MS
657/2002/EC
description Even if coccidiostats are not generally employed in dairy cows, maximum levels for these substances in milk samples have been set up in Commission Regulation 124/2009. Due to public health concerns regarding the presence of veterinary drug residues in milk, the aim of the present work is to report a multi-class high performance liquid chromatography–tandem mass spectrometry method for the simultaneous extraction, identification and quantification of seven coccidiostats, seven antimicrobial agents, three corticosteroids and an antifungal agent. Validation was conducted following the guidelines established in the European Commission Decision 2002/657/CE at the maximum concentration permitted in milk by the European Union for each drug. The method was successfully applied in 100 raw milk samples collected from ten local dairy farms and 15 milk samples bought in supermarkets. This method could be applied in routine analysis of milk samples by the dairy industry, replacing the current, non-differentiating, screening method.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01
2012
2012-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/45558
url https://hdl.handle.net/10347/45558
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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