Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood

Objective: This study was aimed at identifying differences in the prodromal symptoms and their duration, risk factors and markers of vulnerability in patients presenting a first episode mania (FEM) or psychosis (FEP) with onset in late adolescence or adulthood in order to guide tailored treatment st...

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Autores: Verdolini, Norma, Borràs, Roger, Sparacino, Giulio, Garriga, Marina, Sagué Vilavella, Maria, Madero Gómez, Santiago, Palacios Garrán, Roberto, Serra Navarro, Maria, Forte, Maria Florencia, Salagre Muñoz, Estela, Aedo, Alberto, Salgado Pineda, Pilar, Montoro Salvatierra, Irene, Sánchez Gistau, Vanessa, Pomarol-Clotet, Edith, Ramos Quiroga, Josep Antoni, Carvalho, André F., García Rizo, Clemente, Undurraga Fourcade, Juan Pablo, Reinares, María, Martinez Aran, Anabel, Bernardo Arroyo, Miquel, Vieta i Pascual, Eduard, 1963-, Pacchiarotti, Isabella, Amoretti Guadall, Silvia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/190776
Acceso en línea:https://hdl.handle.net/2445/190776
Access Level:acceso abierto
Palabra clave:Psicosi
Trastorn bipolar
Factors de risc en les malalties
Psicosi en els adolescents
Adults
Símptomes
Psychoses
Manic-depressive illness
Risk factors in diseases
Psychoses in adolescence
Adulthood
Symptoms
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spelling Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthoodVerdolini, NormaBorràs, RogerSparacino, GiulioGarriga, MarinaSagué Vilavella, MariaMadero Gómez, SantiagoPalacios Garrán, RobertoSerra Navarro, MariaForte, Maria FlorenciaSalagre Muñoz, EstelaAedo, AlbertoSalgado Pineda, PilarMontoro Salvatierra, IreneSánchez Gistau, VanessaPomarol-Clotet, EdithRamos Quiroga, Josep AntoniCarvalho, André F.García Rizo, ClementeUndurraga Fourcade, Juan PabloReinares, MaríaMartinez Aran, AnabelBernardo Arroyo, MiquelVieta i Pascual, Eduard, 1963-Pacchiarotti, IsabellaAmoretti Guadall, SilviaPsicosiTrastorn bipolarFactors de risc en les malaltiesPsicosi en els adolescentsAdultsSímptomesPsychosesManic-depressive illnessRisk factors in diseasesPsychoses in adolescenceAdulthoodSymptomsObjective: This study was aimed at identifying differences in the prodromal symptoms and their duration, risk factors and markers of vulnerability in patients presenting a first episode mania (FEM) or psychosis (FEP) with onset in late adolescence or adulthood in order to guide tailored treatment strategies. Methods: Patients with a FEM or FEP underwent a clinical assessment. Prodromes were evaluated with the Bipolar Prodrome Symptom Scale-Retrospective (BPSS-R). Chi-squared tests were conducted to assess specific prodromal symptoms, risk factors or markers of vulnerability between groups. Significant prodromal symptoms were entered in a stepwise forward logistic regression model. The probabilities of a gradual versus rapid onset pattern of the prodromes were computed with logistic regression models. Results: The total sample included 108 patients (FEM = 72, FEP = 36). Social isolation was associated with the prodromal stage of a FEP whilst Increased energy or goal-directed activity with the prodrome to a FEM. Physically slowed down presented the most gradual onset whilst Increased energy presented the most rapid. The presence of obstetric complications and difficulties in writing and reading during childhood were risk factors for FEP. As for markers of vulnerability, impairment in premorbid adjustment was characteristic of FEP patients. No specific risk factor or marker of vulnerability was identified for FEM. Conclusion: Early characteristics differentiating FEP from FEM were identified. These findings might help shape early identification and preventive intervention programmes.John Wiley & Sons2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/190776Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1111/acps.13415Acta Psychiatrica Scandinavica, 2022, vol. 146, num. 1, p. 36-50https://doi.org/10.1111/acps.13415cc by-nc-nd (c) Verdolini, Norma et al., 2022http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1907762026-05-29T05:05:01Z
dc.title.none.fl_str_mv Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood
title Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood
spellingShingle Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood
Verdolini, Norma
Psicosi
Trastorn bipolar
Factors de risc en les malalties
Psicosi en els adolescents
Adults
Símptomes
Psychoses
Manic-depressive illness
Risk factors in diseases
Psychoses in adolescence
Adulthood
Symptoms
title_short Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood
title_full Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood
title_fullStr Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood
title_full_unstemmed Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood
title_sort Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood
dc.creator.none.fl_str_mv Verdolini, Norma
Borràs, Roger
Sparacino, Giulio
Garriga, Marina
Sagué Vilavella, Maria
Madero Gómez, Santiago
Palacios Garrán, Roberto
Serra Navarro, Maria
Forte, Maria Florencia
Salagre Muñoz, Estela
Aedo, Alberto
Salgado Pineda, Pilar
Montoro Salvatierra, Irene
Sánchez Gistau, Vanessa
Pomarol-Clotet, Edith
Ramos Quiroga, Josep Antoni
Carvalho, André F.
García Rizo, Clemente
Undurraga Fourcade, Juan Pablo
Reinares, María
Martinez Aran, Anabel
Bernardo Arroyo, Miquel
Vieta i Pascual, Eduard, 1963-
Pacchiarotti, Isabella
Amoretti Guadall, Silvia
author Verdolini, Norma
author_facet Verdolini, Norma
Borràs, Roger
Sparacino, Giulio
Garriga, Marina
Sagué Vilavella, Maria
Madero Gómez, Santiago
Palacios Garrán, Roberto
Serra Navarro, Maria
Forte, Maria Florencia
Salagre Muñoz, Estela
Aedo, Alberto
Salgado Pineda, Pilar
Montoro Salvatierra, Irene
Sánchez Gistau, Vanessa
Pomarol-Clotet, Edith
Ramos Quiroga, Josep Antoni
Carvalho, André F.
García Rizo, Clemente
Undurraga Fourcade, Juan Pablo
Reinares, María
Martinez Aran, Anabel
Bernardo Arroyo, Miquel
Vieta i Pascual, Eduard, 1963-
Pacchiarotti, Isabella
Amoretti Guadall, Silvia
author_role author
author2 Borràs, Roger
Sparacino, Giulio
Garriga, Marina
Sagué Vilavella, Maria
Madero Gómez, Santiago
Palacios Garrán, Roberto
Serra Navarro, Maria
Forte, Maria Florencia
Salagre Muñoz, Estela
Aedo, Alberto
Salgado Pineda, Pilar
Montoro Salvatierra, Irene
Sánchez Gistau, Vanessa
Pomarol-Clotet, Edith
Ramos Quiroga, Josep Antoni
Carvalho, André F.
García Rizo, Clemente
Undurraga Fourcade, Juan Pablo
Reinares, María
Martinez Aran, Anabel
Bernardo Arroyo, Miquel
Vieta i Pascual, Eduard, 1963-
Pacchiarotti, Isabella
Amoretti Guadall, Silvia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Psicosi
Trastorn bipolar
Factors de risc en les malalties
Psicosi en els adolescents
Adults
Símptomes
Psychoses
Manic-depressive illness
Risk factors in diseases
Psychoses in adolescence
Adulthood
Symptoms
topic Psicosi
Trastorn bipolar
Factors de risc en les malalties
Psicosi en els adolescents
Adults
Símptomes
Psychoses
Manic-depressive illness
Risk factors in diseases
Psychoses in adolescence
Adulthood
Symptoms
description Objective: This study was aimed at identifying differences in the prodromal symptoms and their duration, risk factors and markers of vulnerability in patients presenting a first episode mania (FEM) or psychosis (FEP) with onset in late adolescence or adulthood in order to guide tailored treatment strategies. Methods: Patients with a FEM or FEP underwent a clinical assessment. Prodromes were evaluated with the Bipolar Prodrome Symptom Scale-Retrospective (BPSS-R). Chi-squared tests were conducted to assess specific prodromal symptoms, risk factors or markers of vulnerability between groups. Significant prodromal symptoms were entered in a stepwise forward logistic regression model. The probabilities of a gradual versus rapid onset pattern of the prodromes were computed with logistic regression models. Results: The total sample included 108 patients (FEM = 72, FEP = 36). Social isolation was associated with the prodromal stage of a FEP whilst Increased energy or goal-directed activity with the prodrome to a FEM. Physically slowed down presented the most gradual onset whilst Increased energy presented the most rapid. The presence of obstetric complications and difficulties in writing and reading during childhood were risk factors for FEP. As for markers of vulnerability, impairment in premorbid adjustment was characteristic of FEP patients. No specific risk factor or marker of vulnerability was identified for FEM. Conclusion: Early characteristics differentiating FEP from FEM were identified. These findings might help shape early identification and preventive intervention programmes.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/190776
url https://hdl.handle.net/2445/190776
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1111/acps.13415
Acta Psychiatrica Scandinavica, 2022, vol. 146, num. 1, p. 36-50
https://doi.org/10.1111/acps.13415
dc.rights.none.fl_str_mv cc by-nc-nd (c) Verdolini, Norma et al., 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Verdolini, Norma et al., 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414227189432320
score 15,81155

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