Reliability of blood eosinophil count in steady-state bronchiectasis
Rationale: The baseline value of eosinophils in peripheral blood (BEC) has been associated with different degrees of severity, prognosis and response to treatment in patients with bronchiectasis. It is not known, however, if this basal value remains constant over time. Objectives: The aim of this st...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/68448 |
| Acesso em linha: | http://hdl.handle.net/10230/68448 http://dx.doi.org/10.1016/j.pulmoe.2023.11.006 |
| Access Level: | acceso abierto |
| Palavra-chave: | Bronchiectasis Eosinophils Exacerbations Severity |
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Reliability of blood eosinophil count in steady-state bronchiectasisMartínez-García, Miguel ÁngelOlveira, CasildaGirón Moreno, Rosa MaríaGarcía Clemente, Marta MariaMáiz, LuisSibila, OriolGolpe, RafaelRodríguez Hermosa, Juan LuisBarreiro Portela, EstherMéndez, RaúlPrados, ConcepciónRodríguez-López, JuanOscullo, GraceRosa Carrillo, David de laBronchiectasisEosinophilsExacerbationsSeverityRationale: The baseline value of eosinophils in peripheral blood (BEC) has been associated with different degrees of severity, prognosis and response to treatment in patients with bronchiectasis. It is not known, however, if this basal value remains constant over time. Objectives: The aim of this study was to assess whether the BEC remains stable in the long term in patients with bronchiectasis. Methods and measurements: Patients from the RIBRON registry of bronchiectasis diagnosed by computed tomography with at least 2 BEC measurements one year apart were included in the study. Patients with asthma and those taking anti-eosinophilic drugs were excluded. Reliability was assessed using the intra-class correlation coefficient (ICC). A patient with a BEC of at least 300 cells/uL or less than 100 cells/uL was considered eosinophilic or eosinopenic, respectively. Group changes over time were also calculated. Main results: Seven hundred and thirteen patients were finally included, with a mean age of 66.5 (13.2) years (65.8 % women). A total of 2701 BEC measurements were performed, with a median number of measurements per patient of 4 (IQR: 2-5) separated by a median of 12.1 (IQR: 10.5-14.3) months between two consecutive measurements. The ICC was good (>0.75) when calculated between two consecutive measurements (approximately one year apart) but had dropped significantly by the time of the next annual measurements. Similarly, the change from an eosinophilic or eosinopenic patient to a non-eosinophilic or non-eosinopenic patient, respectively, was less than 30 % during the first year with respect to the baseline value but was close to 50 % in later measurements. Conclusions: Given the significant changes observed in the baseline value of the BEC over time, its monitoring is necessary in patients with bronchiectasis in order to more reliably assess its usefulness.Elsevier202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/68448http://dx.doi.org/10.1016/j.pulmoe.2023.11.006reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPulmonology. 2025 Dec 31;31(1):2416836© 2023 Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/684482026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Reliability of blood eosinophil count in steady-state bronchiectasis |
| title |
Reliability of blood eosinophil count in steady-state bronchiectasis |
| spellingShingle |
Reliability of blood eosinophil count in steady-state bronchiectasis Martínez-García, Miguel Ángel Bronchiectasis Eosinophils Exacerbations Severity |
| title_short |
Reliability of blood eosinophil count in steady-state bronchiectasis |
| title_full |
Reliability of blood eosinophil count in steady-state bronchiectasis |
| title_fullStr |
Reliability of blood eosinophil count in steady-state bronchiectasis |
| title_full_unstemmed |
Reliability of blood eosinophil count in steady-state bronchiectasis |
| title_sort |
Reliability of blood eosinophil count in steady-state bronchiectasis |
| dc.creator.none.fl_str_mv |
Martínez-García, Miguel Ángel Olveira, Casilda Girón Moreno, Rosa María García Clemente, Marta Maria Máiz, Luis Sibila, Oriol Golpe, Rafael Rodríguez Hermosa, Juan Luis Barreiro Portela, Esther Méndez, Raúl Prados, Concepción Rodríguez-López, Juan Oscullo, Grace Rosa Carrillo, David de la |
| author |
Martínez-García, Miguel Ángel |
| author_facet |
Martínez-García, Miguel Ángel Olveira, Casilda Girón Moreno, Rosa María García Clemente, Marta Maria Máiz, Luis Sibila, Oriol Golpe, Rafael Rodríguez Hermosa, Juan Luis Barreiro Portela, Esther Méndez, Raúl Prados, Concepción Rodríguez-López, Juan Oscullo, Grace Rosa Carrillo, David de la |
| author_role |
author |
| author2 |
Olveira, Casilda Girón Moreno, Rosa María García Clemente, Marta Maria Máiz, Luis Sibila, Oriol Golpe, Rafael Rodríguez Hermosa, Juan Luis Barreiro Portela, Esther Méndez, Raúl Prados, Concepción Rodríguez-López, Juan Oscullo, Grace Rosa Carrillo, David de la |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Bronchiectasis Eosinophils Exacerbations Severity |
| topic |
Bronchiectasis Eosinophils Exacerbations Severity |
| description |
Rationale: The baseline value of eosinophils in peripheral blood (BEC) has been associated with different degrees of severity, prognosis and response to treatment in patients with bronchiectasis. It is not known, however, if this basal value remains constant over time. Objectives: The aim of this study was to assess whether the BEC remains stable in the long term in patients with bronchiectasis. Methods and measurements: Patients from the RIBRON registry of bronchiectasis diagnosed by computed tomography with at least 2 BEC measurements one year apart were included in the study. Patients with asthma and those taking anti-eosinophilic drugs were excluded. Reliability was assessed using the intra-class correlation coefficient (ICC). A patient with a BEC of at least 300 cells/uL or less than 100 cells/uL was considered eosinophilic or eosinopenic, respectively. Group changes over time were also calculated. Main results: Seven hundred and thirteen patients were finally included, with a mean age of 66.5 (13.2) years (65.8 % women). A total of 2701 BEC measurements were performed, with a median number of measurements per patient of 4 (IQR: 2-5) separated by a median of 12.1 (IQR: 10.5-14.3) months between two consecutive measurements. The ICC was good (>0.75) when calculated between two consecutive measurements (approximately one year apart) but had dropped significantly by the time of the next annual measurements. Similarly, the change from an eosinophilic or eosinopenic patient to a non-eosinophilic or non-eosinopenic patient, respectively, was less than 30 % during the first year with respect to the baseline value but was close to 50 % in later measurements. Conclusions: Given the significant changes observed in the baseline value of the BEC over time, its monitoring is necessary in patients with bronchiectasis in order to more reliably assess its usefulness. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024 2024 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/68448 http://dx.doi.org/10.1016/j.pulmoe.2023.11.006 |
| url |
http://hdl.handle.net/10230/68448 http://dx.doi.org/10.1016/j.pulmoe.2023.11.006 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Pulmonology. 2025 Dec 31;31(1):2416836 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf application/pdf |
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Elsevier |
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Elsevier |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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