Expression Levels of hgcAB Genes and Mercury Availability Jointly Explain Methylmercury Formation in Stratified Brackish Waters

12 pages, 4 figures, supporting information https://pubs.acs.org/doi/10.1021/acs.est.2c0378

Detalles Bibliográficos
Autores: Capo, Eric, Feng, Caiyan, Bravo, Andrea G., Bertilsson, Stefan, Soerensen, Anne L., Pinhassi, Jarone, Buck, Moritz, Karlsson, Camilla, Hawkes, Jeffrey, Björn, Erik
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/280745
Acceso en línea:http://hdl.handle.net/10261/280745
Access Level:acceso abierto
Palabra clave:Mercury
Methylmercury
Mercury chemical speciation
hgcAB genes
hgcAB transcripts
Metagenomics
Metatranscriptomics
Baltic Sea
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spelling Expression Levels of hgcAB Genes and Mercury Availability Jointly Explain Methylmercury Formation in Stratified Brackish WatersCapo, EricFeng, CaiyanBravo, Andrea G.Bertilsson, StefanSoerensen, Anne L.Pinhassi, JaroneBuck, MoritzKarlsson, CamillaHawkes, JeffreyBjörn, ErikMercuryMethylmercuryMercury chemical speciationhgcAB geneshgcAB transcriptsMetagenomicsMetatranscriptomicsBaltic Sea12 pages, 4 figures, supporting information https://pubs.acs.org/doi/10.1021/acs.est.2c0378Neurotoxic methylmercury (MeHg) is formed by microbial methylation of inorganic divalent Hg (HgII) and constitutes severe environmental and human health risks. The methylation is enabled by hgcA and hgcB genes, but it is not known if the associated molecular-level processes are rate-limiting or enable accurate prediction of MeHg formation in nature. In this study, we investigated the relationships between hgc genes and MeHg across redox-stratified water columns in the brackish Baltic Sea. We showed, for the first time, that hgc transcript abundance and the concentration of dissolved HgII-sulfide species were strong predictors of both the HgII methylation rate and MeHg concentration, implying their roles as principal joint drivers of MeHg formation in these systems. Additionally, we characterized the metabolic capacities of hgc+ microorganisms by reconstructing their genomes from metagenomes (i.e., hgc+ MAGs), which highlighted the versatility of putative HgII methylators in the water column of the Baltic Sea. In establishing relationships between hgc transcripts and the HgII methylation rate, we advance the fundamental understanding of mechanistic principles governing MeHg formation in nature and enable refined predictions of MeHg levels in coastal seas in response to the accelerating spread of oxygen-deficient zonesThis work was funded by the Swedish Research Council Formas (grant 2018-01031), the Carl Trygger Foundation for Scientific Research (grant CTS 18:41), Kempestiftelserna (grants SMK-1753 and SMK-1243), the EMFF-Blue Economy project MER-CLUB (grant 863584), the Severo Ochoa Excellence Program Postdoctoral Fellowship (CEX2019-000928-S), and the Marie Curie Individual Fellowship (H2020-MSCA-IF-2016; project-749645)Peer reviewedAmerican Chemical SocietySwedish Research CouncilCarl Trygger FoundationKempestiftelsernaEuropean Maritime and Fisheries FundAgencia Estatal de Investigación (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/280745reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/749645https://doi.org/10.1021/acs.est.2c03784Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2807452026-05-22T06:33:51Z
dc.title.none.fl_str_mv Expression Levels of hgcAB Genes and Mercury Availability Jointly Explain Methylmercury Formation in Stratified Brackish Waters
title Expression Levels of hgcAB Genes and Mercury Availability Jointly Explain Methylmercury Formation in Stratified Brackish Waters
spellingShingle Expression Levels of hgcAB Genes and Mercury Availability Jointly Explain Methylmercury Formation in Stratified Brackish Waters
Capo, Eric
Mercury
Methylmercury
Mercury chemical speciation
hgcAB genes
hgcAB transcripts
Metagenomics
Metatranscriptomics
Baltic Sea
title_short Expression Levels of hgcAB Genes and Mercury Availability Jointly Explain Methylmercury Formation in Stratified Brackish Waters
title_full Expression Levels of hgcAB Genes and Mercury Availability Jointly Explain Methylmercury Formation in Stratified Brackish Waters
title_fullStr Expression Levels of hgcAB Genes and Mercury Availability Jointly Explain Methylmercury Formation in Stratified Brackish Waters
title_full_unstemmed Expression Levels of hgcAB Genes and Mercury Availability Jointly Explain Methylmercury Formation in Stratified Brackish Waters
title_sort Expression Levels of hgcAB Genes and Mercury Availability Jointly Explain Methylmercury Formation in Stratified Brackish Waters
dc.creator.none.fl_str_mv Capo, Eric
Feng, Caiyan
Bravo, Andrea G.
Bertilsson, Stefan
Soerensen, Anne L.
Pinhassi, Jarone
Buck, Moritz
Karlsson, Camilla
Hawkes, Jeffrey
Björn, Erik
author Capo, Eric
author_facet Capo, Eric
Feng, Caiyan
Bravo, Andrea G.
Bertilsson, Stefan
Soerensen, Anne L.
Pinhassi, Jarone
Buck, Moritz
Karlsson, Camilla
Hawkes, Jeffrey
Björn, Erik
author_role author
author2 Feng, Caiyan
Bravo, Andrea G.
Bertilsson, Stefan
Soerensen, Anne L.
Pinhassi, Jarone
Buck, Moritz
Karlsson, Camilla
Hawkes, Jeffrey
Björn, Erik
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Swedish Research Council
Carl Trygger Foundation
Kempestiftelserna
European Maritime and Fisheries Fund
Agencia Estatal de Investigación (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Mercury
Methylmercury
Mercury chemical speciation
hgcAB genes
hgcAB transcripts
Metagenomics
Metatranscriptomics
Baltic Sea
topic Mercury
Methylmercury
Mercury chemical speciation
hgcAB genes
hgcAB transcripts
Metagenomics
Metatranscriptomics
Baltic Sea
description 12 pages, 4 figures, supporting information https://pubs.acs.org/doi/10.1021/acs.est.2c0378
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/280745
url http://hdl.handle.net/10261/280745
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/749645
https://doi.org/10.1021/acs.est.2c03784
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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