Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC): Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group

The main aim is to compare oncological outcomes and patterns of recurrence of patients with early-stage endometrioid endometrial cancer according to lymphovascular space invasion (LVSI) status. The secondary objective is to determine preoperative predictors of LVSI. We performed a multicenter retros...

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Detalles Bibliográficos
Autores: Oliver Pérez, María De Los Reyes, Padilla Iserte, Pablo, Arencibia Sánchez, Octavio, Martín Arriscado, Cristina, Muruzabal, Juan Carlos, Díaz Feijóo, Berta, Cabrera, Silvia, Coronado Martín, Pluvio Jesús, Martín Salamanca, M. Belén, Pantoja Garrido, Manuel, Marcos Sanmartin, Josefa, Cabezas López, Elena, Lorenzo, Cristina, Beric, Duska, Rodríguez Hernández, José Ramón, Roldán Rivas, Fernando, Gilabert Estrelles, Juan, Sánchez, Lourdes, Laseca Modrego, María, Tauste Rubio, Carmen, Gil Ibáñez, Blanca, Tejerizo García, Álvaro
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/103440
Acceso en línea:https://hdl.handle.net/20.500.14352/103440
Access Level:acceso abierto
Palabra clave:616-006.04
618.1
Endometrial cancer
Recurrence
Survival
LVSI
Lymphovascular space invasion
Salud pública (Medicina)
Oncología
Ginecología y obstetricia
3212 Salud Publica
3201.01 Oncología
3201.08 Ginecología
Descripción
Sumario:The main aim is to compare oncological outcomes and patterns of recurrence of patients with early-stage endometrioid endometrial cancer according to lymphovascular space invasion (LVSI) status. The secondary objective is to determine preoperative predictors of LVSI. We performed a multicenter retrospective cohort study. A total of 3546 women diagnosed with postoperative early-stage (FIGO I-II, 2009) endometrioid endometrial cancer were included. Co-primary endpoints were disease-free survival (DFS), overall survival (OS), and pattern of recurrence. Cox proportional hazard models were used for time-to-event analysis. Univariate and multivariate logistical regression models were employed. Positive LVSI was identified in 528 patients (14.6%) and was an independent prognostic factor for DFS (HR 1.8), OS (HR 2.1) and distant recurrences (HR 2.37). Distant recurrences were more frequent in patients with positive LVSI (78.2% vs. 61.3%, p < 0.01). Deep myometrial invasion (OR 3.04), high-grade tumors (OR 2.54), cervical stroma invasion (OR 2.01), and tumor diameter ≥ 2 cm (OR 2.03) were independent predictors of LVSI. In conclusion, in these patients, LVSI is an independent risk factor for shorter DFS and OS, and distant recurrence, but not for local recurrence. Deep myometrial invasion, cervical stroma invasion, high-grade tumors, and a tumor diameter ≥ 2 cm are independent predictors of LVSI.

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