Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions

10 páginas, 7 figuras, 3 tablas. PMID:22065589[PubMed] PMCID:PMC3247988[Available on 2012/12/30]

Detalles Bibliográficos
Autores: Palacios-Rodríguez, Yadira, García-Laínez, Guillermo, Sancho, Mónica, Gortat, Anna, Orzáez, Mar, Pérez-Payá, Enrique
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/48108
Acceso en línea:http://hdl.handle.net/10261/48108
Access Level:acceso abierto
Palabra clave:Apaf-1
Apoptosis
Apoptosome
Caspase-1
Caspase-9
CarD
Inflammasome
Inhibitors
NLRP-1
NOD
ASC
peptides
procaspase-1
procaspase-9
protein-protein
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oai_identifier_str oai:digital.csic.es:10261/48108
network_acronym_str ES
network_name_str España
repository_id_str
spelling Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactionsPalacios-Rodríguez, YadiraGarcía-Laínez, GuillermoSancho, MónicaGortat, AnnaOrzáez, MarPérez-Payá, EnriqueApaf-1ApoptosisApoptosomeCaspase-1Caspase-9CarDInflammasomeInhibitorsNLRP-1NODASCpeptidesprocaspase-1procaspase-9protein-protein10 páginas, 7 figuras, 3 tablas. PMID:22065589[PubMed] PMCID:PMC3247988[Available on 2012/12/30]The caspase recruitment domain (CARD) is present in a large number of proteins. Initially, the CARD was recognized as part of the caspase activation machinery. CARD-CARD interactions play a role in apoptosis and are responsible for the Apaf-1-mediated activation of procaspase-9 in the apoptosome. CARD-containing proteins mediate the inflammasome-dependent activation of proinflammatory caspase-1. More recently, new roles for CARD-containing proteins have been reported in signaling pathways associated with immune responses. The functional role of CARD-containing proteins and CARDs in coordinating apoptosis and inflammatory and immune responses is not completely understood. We have explored the putative cross-talk between apoptosis and inflammation by analyzing the modulatory activity on both the Apaf-1/procaspase-9 interaction and the inflammasome-mediated procaspase-1 activation of CARD-derived polypeptides. To this end, we analyzed the activity of individual recombinant CARDs, rationally designed CARD-derived peptides, and peptides derived from phage display.This work has been supported by grants from the Spanish Ministry of Science and Innovation (MICINN - BIO2007-60066 and SAF2010 15512), Laboratorios Salvat, SA, Generalitat Valenciana Prometeo 2010/005 (partially funded with ERDF) and Consolider-Ingenio 2010 (MICINN - CSD2008-00005C) to E.P.-P. Y. P.-R. was supported by a postdoctoral fellowship from the National Autonomous University of Mexico and Consejo Superior de Investigaciones Científicas, Spain (UNAM - CSIC). G. G.-L. acknowledges financial support through JAE-Pre from the CSIC.Peer reviewedAmerican Society for Biochemistry and Molecular Biology201220122011info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/48108reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1074/jbc.M111.255364info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/481082026-05-22T06:33:51Z
dc.title.none.fl_str_mv Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions
title Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions
spellingShingle Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions
Palacios-Rodríguez, Yadira
Apaf-1
Apoptosis
Apoptosome
Caspase-1
Caspase-9
CarD
Inflammasome
Inhibitors
NLRP-1
NOD
ASC
peptides
procaspase-1
procaspase-9
protein-protein
title_short Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions
title_full Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions
title_fullStr Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions
title_full_unstemmed Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions
title_sort Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions
dc.creator.none.fl_str_mv Palacios-Rodríguez, Yadira
García-Laínez, Guillermo
Sancho, Mónica
Gortat, Anna
Orzáez, Mar
Pérez-Payá, Enrique
author Palacios-Rodríguez, Yadira
author_facet Palacios-Rodríguez, Yadira
García-Laínez, Guillermo
Sancho, Mónica
Gortat, Anna
Orzáez, Mar
Pérez-Payá, Enrique
author_role author
author2 García-Laínez, Guillermo
Sancho, Mónica
Gortat, Anna
Orzáez, Mar
Pérez-Payá, Enrique
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Apaf-1
Apoptosis
Apoptosome
Caspase-1
Caspase-9
CarD
Inflammasome
Inhibitors
NLRP-1
NOD
ASC
peptides
procaspase-1
procaspase-9
protein-protein
topic Apaf-1
Apoptosis
Apoptosome
Caspase-1
Caspase-9
CarD
Inflammasome
Inhibitors
NLRP-1
NOD
ASC
peptides
procaspase-1
procaspase-9
protein-protein
description 10 páginas, 7 figuras, 3 tablas. PMID:22065589[PubMed] PMCID:PMC3247988[Available on 2012/12/30]
publishDate 2011
dc.date.none.fl_str_mv 2011
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/48108
url http://hdl.handle.net/10261/48108
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1074/jbc.M111.255364
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414179959472128
score 15,81155

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