Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Complicacions infeccioses; Càncer

Detalles Bibliográficos
Autores: Gudiol, Carlota, Durà-Miralles, X., Aguilar-Company, Juan, Hernández-Jiménez, P., Martínez-Cutillas, M., Fernández-Avilés, Francesc
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/6888
Acceso en línea:https://hdl.handle.net/11351/6888
Access Level:acceso abierto
Palabra clave:COVID-19 (Malaltia)
Càncer - Complicacions
Infeccions oportunistes
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
DISEASES::Neoplasms
Other subheadings::Other subheadings::Other subheadings::/complications
DISEASES::Virus Diseases::Coinfection
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
ENFERMEDADES::virosis::coinfección
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oai_identifier_str oai:scientiasalut.gencat.cat:11351/6888
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study
title Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study
spellingShingle Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study
Gudiol, Carlota
COVID-19 (Malaltia)
Càncer - Complicacions
Infeccions oportunistes
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
DISEASES::Neoplasms
Other subheadings::Other subheadings::Other subheadings::/complications
DISEASES::Virus Diseases::Coinfection
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
ENFERMEDADES::virosis::coinfección
title_short Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study
title_full Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study
title_fullStr Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study
title_full_unstemmed Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study
title_sort Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study
dc.creator.none.fl_str_mv Gudiol, Carlota
Durà-Miralles, X.
Aguilar-Company, Juan
Hernández-Jiménez, P.
Martínez-Cutillas, M.
Fernández-Avilés, Francesc
author Gudiol, Carlota
author_facet Gudiol, Carlota
Durà-Miralles, X.
Aguilar-Company, Juan
Hernández-Jiménez, P.
Martínez-Cutillas, M.
Fernández-Avilés, Francesc
author_role author
author2 Durà-Miralles, X.
Aguilar-Company, Juan
Hernández-Jiménez, P.
Martínez-Cutillas, M.
Fernández-Avilés, Francesc
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Gudiol C] Department of Infectious Diseases, Biostatistics Unit, Bellvitge University Hospital, Bellvitge Institute for Biomedical Research (IDIBELL), University of Barcelona, Barcelona, Spain. Institut Català d’Oncologia, IDIBELL, University of Barcelona, Barcelona, Spain. Spainsh Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain. [Durà-Miralles X] Department of Infectious Diseases, Biostatistics Unit, Bellvitge University Hospital, Bellvitge Institute for Biomedical Research (IDIBELL), University of Barcelona, Barcelona, Spain. Spainsh Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain. [Aguilar-Company J] Servei d’Oncologia Mèdica; Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Hernández-Jiménez P] Infectious Diseases Unit, 12 de Octubre University Hospital, Madrid, Spain. [Martínez-Cutillas M] Medical Oncology Department, Puerta de Hierro University Hospital, Madrid, Spain. [Fernandez-Avilés F] Bone Marrow Transplantation Unit, Department of Haematology, Hospital Clinic of Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv COVID-19 (Malaltia)
Càncer - Complicacions
Infeccions oportunistes
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
DISEASES::Neoplasms
Other subheadings::Other subheadings::Other subheadings::/complications
DISEASES::Virus Diseases::Coinfection
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
ENFERMEDADES::virosis::coinfección
topic COVID-19 (Malaltia)
Càncer - Complicacions
Infeccions oportunistes
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
DISEASES::Neoplasms
Other subheadings::Other subheadings::Other subheadings::/complications
DISEASES::Virus Diseases::Coinfection
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
ENFERMEDADES::virosis::coinfección
description Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Complicacions infeccioses; Càncer
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/6888
url https://hdl.handle.net/11351/6888
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Infection;83(3)
https://doi.org/10.1016/j.jinf.2021.07.014
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414141243949056
spelling Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international studyGudiol, CarlotaDurà-Miralles, X.Aguilar-Company, JuanHernández-Jiménez, P.Martínez-Cutillas, M.Fernández-Avilés, FrancescCOVID-19 (Malaltia)Càncer - ComplicacionsInfeccions oportunistesDISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus InfectionsDISEASES::NeoplasmsOther subheadings::Other subheadings::Other subheadings::/complicationsDISEASES::Virus Diseases::CoinfectionENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por CoronavirusENFERMEDADES::neoplasiasOtros calificadores::Otros calificadores::Otros calificadores::/complicacionesENFERMEDADES::virosis::coinfecciónCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Complicacions infeccioses; CàncerCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Complicaciones infecciosas; CáncerCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Infectious complications; CancerBackground We aimed to describe the epidemiology, risk factors, and clinical outcomes of co-infections and superinfections in onco-hematological patients with COVID-19. Methods International, multicentre cohort study of cancer patients with COVID-19. All patients were included in the analysis of co-infections at diagnosis, while only patients admitted at least 48 h were included in the analysis of superinfections. Results 684 patients were included (384 with solid tumors and 300 with hematological malignancies). Co-infections and superinfections were documented in 7.8% (54/684) and 19.1% (113/590) of patients, respectively. Lower respiratory tract infections were the most frequent infectious complications, most often caused by Streptococcus pneumoniae and Pseudomonas aeruginosa . Only seven patients developed opportunistic infections. Compared to patients without infectious complications, those with infections had worse outcomes, with high rates of acute respiratory distress syndrome, intensive care unit (ICU) admission, and case-fatality rates. Neutropenia, ICU admission and high levels of C-reactive protein (CRP) were independent risk factors for infections. Conclusions Infectious complications in cancer patients with COVID-19 were lower than expected, affecting mainly neutropenic patients with high levels of CRP and/or ICU admission. The rate of opportunistic infections was unexpectedly low. The use of empiric antimicrobials in cancer patients with COVID-19 needs to be optimized.This study was supported by the Spanish Plan Nacional de IDi 2013-2016, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía, Industria y Competitividad, and the Spanish Network for Research in Infectious Diseases (REIPI grant: RD16/0016/0001). It was also co-financed by the European Development Regional Fund ‘A Way to Make Europe’, Operational Programme Smart Growth 2014-2020.ElsevierInstitut Català de la Salut[Gudiol C] Department of Infectious Diseases, Biostatistics Unit, Bellvitge University Hospital, Bellvitge Institute for Biomedical Research (IDIBELL), University of Barcelona, Barcelona, Spain. Institut Català d’Oncologia, IDIBELL, University of Barcelona, Barcelona, Spain. Spainsh Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain. [Durà-Miralles X] Department of Infectious Diseases, Biostatistics Unit, Bellvitge University Hospital, Bellvitge Institute for Biomedical Research (IDIBELL), University of Barcelona, Barcelona, Spain. Spainsh Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain. [Aguilar-Company J] Servei d’Oncologia Mèdica; Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Hernández-Jiménez P] Infectious Diseases Unit, 12 de Octubre University Hospital, Madrid, Spain. [Martínez-Cutillas M] Medical Oncology Department, Puerta de Hierro University Hospital, Madrid, Spain. [Fernandez-Avilés F] Bone Marrow Transplantation Unit, Department of Haematology, Hospital Clinic of Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/6888Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésJournal of Infection;83(3)https://doi.org/10.1016/j.jinf.2021.07.014Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/68882026-06-12T09:38:37Z
score 15,81155

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