Magnetic Nanoparticles as MRI Contrast Agents

Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high biocompatibility and excellent magnetic properties. Furthermore, the ease of functiona...

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Detalles Bibliográficos
Autores: Avasthi, Ashish, Caro, Carlos, Pozo-Torres, Esther, Pernia Leal, Manuel, García-Martín, María Luisa
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18045
Acceso en línea:http://hdl.handle.net/20.500.12105/18045
Access Level:acceso abierto
Palabra clave:Magnetic nanoparticles
Iron oxide nanoparticles
Magnetic resonance imaging
Cancer
Diagnosis
Nanopartículas magnéticas de óxido de hierro
Imagen por resonancia magnética
Neoplasias
Diagnóstico
Animals
Contrast Media
Humans
Magnetic Resonance Imaging
Magnetite Nanoparticles
Neoplasms
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spelling Magnetic Nanoparticles as MRI Contrast AgentsAvasthi, AshishCaro, CarlosPozo-Torres, EstherPernia Leal, ManuelGarcía-Martín, María LuisaMagnetic nanoparticlesIron oxide nanoparticlesMagnetic resonance imagingCancerDiagnosisNanopartículas magnéticas de óxido de hierroImagen por resonancia magnéticaNeoplasiasDiagnósticoAnimalsContrast MediaHumansMagnetic Resonance ImagingMagnetite NanoparticlesNeoplasmsDiagnosisIron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high biocompatibility and excellent magnetic properties. Furthermore, the ease of functionalization of their surfaces with different types of ligands (antibodies, peptides, sugars, etc.) opens up the possibility of carrying out molecular MRI. Thus, IONPs functionalized with epithelial growth factor receptor antibodies, short peptides, like RGD, or aptamers, among others, have been proposed for the diagnosis of various types of cancer, including breast, stomach, colon, kidney, liver or brain cancer. In addition to cancer diagnosis, different types of IONPs have been developed for other applications, such as the detection of brain inflammation or the early diagnosis of thrombosis. This review addresses key aspects in the development of IONPs for MRI applications, namely, synthesis of the inorganic core, functionalization processes to make IONPs biocompatible and also to target them to specific tissues or cells, and finally in vivo studies in animal models, with special emphasis on tumor models.Springer[Avasthi,A; Caro,C; García-Martín,ML] BIONAND - Centro Andaluz de Nanomedicina y Biotecnología, Junta de Andalucía-Universidad de Málaga, Málaga, Spain. [Pozo-Torres,E; Pernia Leal,M] Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain. [García-Martín,ML] Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Málaga, Spain.20242024-02-1220202020-05-0720202020-05-07review articlehttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/18045reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/180452026-06-12T12:43:37Z
dc.title.none.fl_str_mv Magnetic Nanoparticles as MRI Contrast Agents
title Magnetic Nanoparticles as MRI Contrast Agents
spellingShingle Magnetic Nanoparticles as MRI Contrast Agents
Avasthi, Ashish
Magnetic nanoparticles
Iron oxide nanoparticles
Magnetic resonance imaging
Cancer
Diagnosis
Nanopartículas magnéticas de óxido de hierro
Imagen por resonancia magnética
Neoplasias
Diagnóstico
Animals
Contrast Media
Humans
Magnetic Resonance Imaging
Magnetite Nanoparticles
Neoplasms
Diagnosis
title_short Magnetic Nanoparticles as MRI Contrast Agents
title_full Magnetic Nanoparticles as MRI Contrast Agents
title_fullStr Magnetic Nanoparticles as MRI Contrast Agents
title_full_unstemmed Magnetic Nanoparticles as MRI Contrast Agents
title_sort Magnetic Nanoparticles as MRI Contrast Agents
dc.creator.none.fl_str_mv Avasthi, Ashish
Caro, Carlos
Pozo-Torres, Esther
Pernia Leal, Manuel
García-Martín, María Luisa
author Avasthi, Ashish
author_facet Avasthi, Ashish
Caro, Carlos
Pozo-Torres, Esther
Pernia Leal, Manuel
García-Martín, María Luisa
author_role author
author2 Caro, Carlos
Pozo-Torres, Esther
Pernia Leal, Manuel
García-Martín, María Luisa
author2_role author
author
author
author
dc.contributor.none.fl_str_mv [Avasthi,A; Caro,C; García-Martín,ML] BIONAND - Centro Andaluz de Nanomedicina y Biotecnología, Junta de Andalucía-Universidad de Málaga, Málaga, Spain. [Pozo-Torres,E; Pernia Leal,M] Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain. [García-Martín,ML] Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Málaga, Spain.
dc.subject.none.fl_str_mv Magnetic nanoparticles
Iron oxide nanoparticles
Magnetic resonance imaging
Cancer
Diagnosis
Nanopartículas magnéticas de óxido de hierro
Imagen por resonancia magnética
Neoplasias
Diagnóstico
Animals
Contrast Media
Humans
Magnetic Resonance Imaging
Magnetite Nanoparticles
Neoplasms
Diagnosis
topic Magnetic nanoparticles
Iron oxide nanoparticles
Magnetic resonance imaging
Cancer
Diagnosis
Nanopartículas magnéticas de óxido de hierro
Imagen por resonancia magnética
Neoplasias
Diagnóstico
Animals
Contrast Media
Humans
Magnetic Resonance Imaging
Magnetite Nanoparticles
Neoplasms
Diagnosis
description Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high biocompatibility and excellent magnetic properties. Furthermore, the ease of functionalization of their surfaces with different types of ligands (antibodies, peptides, sugars, etc.) opens up the possibility of carrying out molecular MRI. Thus, IONPs functionalized with epithelial growth factor receptor antibodies, short peptides, like RGD, or aptamers, among others, have been proposed for the diagnosis of various types of cancer, including breast, stomach, colon, kidney, liver or brain cancer. In addition to cancer diagnosis, different types of IONPs have been developed for other applications, such as the detection of brain inflammation or the early diagnosis of thrombosis. This review addresses key aspects in the development of IONPs for MRI applications, namely, synthesis of the inorganic core, functionalization processes to make IONPs biocompatible and also to target them to specific tissues or cells, and finally in vivo studies in animal models, with special emphasis on tumor models.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-05-07
2020
2020-05-07
2024
2024-02-12
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/18045
url http://hdl.handle.net/20.500.12105/18045
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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