Age-standardized comparison of coronary artery disease, stroke incidence, and all-cause mortality between people living with HIV and the general population in Spain
Objectives: We compared 15-year incidence of coronary artery disease (CAD), stroke, and all-cause mortality between people living with HIV (PLWH) and the Spanish general population. Methods: We compared two Spanish cohorts-VACH (PLWH) and REGICOR (general population). We followed adults aged 25-74 y...
| Autores: | , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repositorio: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p20313 |
| Acesso em linha: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20313 |
| Access Level: | acceso abierto |
| Palavra-chave: | People living with HIV Coronary artery disease Stroke Incidence General population All-cause mortality |
| Resumo: | Objectives: We compared 15-year incidence of coronary artery disease (CAD), stroke, and all-cause mortality between people living with HIV (PLWH) and the Spanish general population. Methods: We compared two Spanish cohorts-VACH (PLWH) and REGICOR (general population). We followed adults aged 25-74 years, free of CAD or stroke, for a mean of 15 years. We used age-standardized 15-year incidence of CAD, stroke, and all-cause mortality and compared cohorts with log-rank tests and Cox models adjusted for confounders. Results: We included 6829 PLWH and 10,218 general population. In men aged 25-54 years with HIV, the adjusted standardized incidence rates of CAD and stroke were similar to those in the general population. In addition, PLWH had significantly higher crude all-cause standardized mortality rates than the general population: men 2790 (2536-3044) vs 1104 (1015-1192) and women 2011 (1632-2391) vs 588 (528-648) (all P-values <0.001). Moreover, the adjusted hazard ratio of all-cause mortality was much higher in PLWH younger than 55 years (hazard ratio 3.08 [2.42-3.90] in men and 4.71 [3.13-7.09] in women). Conclusions: The adjusted risk of CAD and stroke among PLWH is similar to that of the general population. However, PLWH younger than 55 years still face a more than three-fold higher risk of death from any cause. (c) 2025 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) |
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