Epidemiology of dermatomyositis and other idiopathic inflammatory myopathies in northern Spain

Background/Objectives: The epidemiology of dermatomyositis (DM) and other idiopathic inflammatory myopathies (IIMs) remains not well established, especially in the Mediterranean region. We aimed to estimate the prevalence and incidence of IIM in a well-defined population of South Europe using standa...

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Authors: Corrales Selaya, Cristina, Prieto Peña, Diana, Martínez López, David, Benavides Villanueva, Fabricio, Blanco Alonso, Ricardo|||0000-0003-2344-2285
Format: article
Publication Date:2025
Country:España
Institution:Universidad de Cantabria (UC)
Repository:UCrea Repositorio Abierto de la Universidad de Cantabria
Language:English
OAI Identifier:oai:repositorio.unican.es:10902/38813
Online Access:https://hdl.handle.net/10902/38813
Access Level:Open access
Keyword:Idiopathic inflammatory myopathies
Dermatomyositis
Polymyositis
Antisynthetase syndrome
Immune-mediated necrotizing myopathy
Epidemiology
Prevalence
Incidence rate
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spelling Epidemiology of dermatomyositis and other idiopathic inflammatory myopathies in northern SpainCorrales Selaya, CristinaPrieto Peña, DianaMartínez López, DavidBenavides Villanueva, FabricioBlanco Alonso, Ricardo|||0000-0003-2344-2285Idiopathic inflammatory myopathiesDermatomyositisPolymyositisAntisynthetase syndromeImmune-mediated necrotizing myopathyEpidemiologyPrevalenceIncidence rateBackground/Objectives: The epidemiology of dermatomyositis (DM) and other idiopathic inflammatory myopathies (IIMs) remains not well established, especially in the Mediterranean region. We aimed to estimate the prevalence and incidence of IIM in a well-defined population of South Europe using standardized classification criteria. Methods: This population-based study included all IIM patients diagnosed from January 2000 to December 2022 in Cantabria, Northern Spain. IIM diagnosis was confirmed by fulfillment of the 2017 EULAR/ACR classification criteria or, alternatively, by European Neuro Muscular Center criteria for immune-mediated necrotizing myopathy (IMNM) and Connors' criteria for antisynthetase syndrome (ASyS). Prevalence and incidence were expressed in cases per 100,000. A literature review was also performed. Results: A total of 60 patients (41 women, 19 men; mean age 52.6 ± 18.8 years) were included. The prevalence of IIM was 20 cases per 100,000 population [95% CI 14.5-25.1], and the annual incidence rate was 0.9 cases per 100,000 person-years [95% CI 0.6-1.14]. A significant upward trend in IIM incidence was observed with an estimated annual percentage change of 5.74% (95% CI: 2.16%-9.44%, p = 0.0015). The most common subtype was DM (n = 31, 51.7%), followed by ASyS (n = 17, 24%), IMNM (n = 9, 14.6%), and polymyositis (PM) (n = 3, 4.7%). No inclusion body myositis (IBM) cases were identified. Conclusions: Incidence and prevalence of IIM align with prior reports. We observed an increase in IIM incidence and a shift in subtype distribution, with ASyS and IMNM becoming more frequent. These findings have clinical relevance, as each IIM subtype carries distinct prognostic and therapeutic implications.MDPIUniversidad de Cantabria20252025-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/38813Biomedicines, 2025, 13(10), 2537reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/388132026-06-02T12:39:31Z
dc.title.none.fl_str_mv Epidemiology of dermatomyositis and other idiopathic inflammatory myopathies in northern Spain
title Epidemiology of dermatomyositis and other idiopathic inflammatory myopathies in northern Spain
spellingShingle Epidemiology of dermatomyositis and other idiopathic inflammatory myopathies in northern Spain
Corrales Selaya, Cristina
Idiopathic inflammatory myopathies
Dermatomyositis
Polymyositis
Antisynthetase syndrome
Immune-mediated necrotizing myopathy
Epidemiology
Prevalence
Incidence rate
title_short Epidemiology of dermatomyositis and other idiopathic inflammatory myopathies in northern Spain
title_full Epidemiology of dermatomyositis and other idiopathic inflammatory myopathies in northern Spain
title_fullStr Epidemiology of dermatomyositis and other idiopathic inflammatory myopathies in northern Spain
title_full_unstemmed Epidemiology of dermatomyositis and other idiopathic inflammatory myopathies in northern Spain
title_sort Epidemiology of dermatomyositis and other idiopathic inflammatory myopathies in northern Spain
dc.creator.none.fl_str_mv Corrales Selaya, Cristina
Prieto Peña, Diana
Martínez López, David
Benavides Villanueva, Fabricio
Blanco Alonso, Ricardo|||0000-0003-2344-2285
author Corrales Selaya, Cristina
author_facet Corrales Selaya, Cristina
Prieto Peña, Diana
Martínez López, David
Benavides Villanueva, Fabricio
Blanco Alonso, Ricardo|||0000-0003-2344-2285
author_role author
author2 Prieto Peña, Diana
Martínez López, David
Benavides Villanueva, Fabricio
Blanco Alonso, Ricardo|||0000-0003-2344-2285
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Idiopathic inflammatory myopathies
Dermatomyositis
Polymyositis
Antisynthetase syndrome
Immune-mediated necrotizing myopathy
Epidemiology
Prevalence
Incidence rate
topic Idiopathic inflammatory myopathies
Dermatomyositis
Polymyositis
Antisynthetase syndrome
Immune-mediated necrotizing myopathy
Epidemiology
Prevalence
Incidence rate
description Background/Objectives: The epidemiology of dermatomyositis (DM) and other idiopathic inflammatory myopathies (IIMs) remains not well established, especially in the Mediterranean region. We aimed to estimate the prevalence and incidence of IIM in a well-defined population of South Europe using standardized classification criteria. Methods: This population-based study included all IIM patients diagnosed from January 2000 to December 2022 in Cantabria, Northern Spain. IIM diagnosis was confirmed by fulfillment of the 2017 EULAR/ACR classification criteria or, alternatively, by European Neuro Muscular Center criteria for immune-mediated necrotizing myopathy (IMNM) and Connors' criteria for antisynthetase syndrome (ASyS). Prevalence and incidence were expressed in cases per 100,000. A literature review was also performed. Results: A total of 60 patients (41 women, 19 men; mean age 52.6 ± 18.8 years) were included. The prevalence of IIM was 20 cases per 100,000 population [95% CI 14.5-25.1], and the annual incidence rate was 0.9 cases per 100,000 person-years [95% CI 0.6-1.14]. A significant upward trend in IIM incidence was observed with an estimated annual percentage change of 5.74% (95% CI: 2.16%-9.44%, p = 0.0015). The most common subtype was DM (n = 31, 51.7%), followed by ASyS (n = 17, 24%), IMNM (n = 9, 14.6%), and polymyositis (PM) (n = 3, 4.7%). No inclusion body myositis (IBM) cases were identified. Conclusions: Incidence and prevalence of IIM align with prior reports. We observed an increase in IIM incidence and a shift in subtype distribution, with ASyS and IMNM becoming more frequent. These findings have clinical relevance, as each IIM subtype carries distinct prognostic and therapeutic implications.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/38813
url https://hdl.handle.net/10902/38813
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Biomedicines, 2025, 13(10), 2537
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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