The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries

Although there is robust evidence linking childhood adversities (CAs) and an increased risk for psychotic experiences (PEs), little is known about whether these associations vary across the life-course and whether mental disorders that emerge prior to PEs explain these associations. METHOD: We asses...

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Autores: McGrath, John J., McLaughlin, K. A., Saha, Sukanta, Aguilar-Gaxiola, Sergio, Al-Hamzawi, Ali Obaid, Alonso, Jordi, Bruffaerts, Ronny, Girolamo, Giovanni de, Jonge, Peter de, Esan, O., Florescu, Silvia E., Gureje, Oye, Haro Abad, Josep Maria, Hu, Chiyi, Karam, Elie Georges, Kovess-Masfety, Viviane, Lee, Soon Yeun, Lepine, Jean Pierre, Lim, Carmen C. W., Medina Mora, Maria Elena, Mneimneh, Z., Pennell, Beth-Ellen, Piazza, Marina, Posada Villa, José, Sampson, Nancy A., Viana, Maria Carmen, Xavier, Miguel, Bromet, Evelyn J., Kendler, Kenneth S., Kessler, Ronald C.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/120251
Acceso en línea:https://hdl.handle.net/2445/120251
Access Level:acceso abierto
Palabra clave:Malalties mentals
Infants
Mental illness
Children
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spelling The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countriesMcGrath, John J.McLaughlin, K. A.Saha, SukantaAguilar-Gaxiola, SergioAl-Hamzawi, Ali ObaidAlonso, JordiBruffaerts, RonnyGirolamo, Giovanni deJonge, Peter deEsan, O.Florescu, Silvia E.Gureje, OyeHaro Abad, Josep MariaHu, ChiyiKaram, Elie GeorgesKovess-Masfety, VivianeLee, Soon YeunLepine, Jean PierreLim, Carmen C. W.Medina Mora, Maria ElenaMneimneh, Z.Pennell, Beth-EllenPiazza, MarinaPosada Villa, JoséSampson, Nancy A.Viana, Maria CarmenXavier, MiguelBromet, Evelyn J.Kendler, Kenneth S.Kessler, Ronald C.Malalties mentalsInfantsMental illnessChildrenAlthough there is robust evidence linking childhood adversities (CAs) and an increased risk for psychotic experiences (PEs), little is known about whether these associations vary across the life-course and whether mental disorders that emerge prior to PEs explain these associations. METHOD: We assessed CAs, PEs and DSM-IV mental disorders in 23 998 adults in the WHO World Mental Health Surveys. Discrete-time survival analysis was used to investigate the associations between CAs and PEs, and the influence of mental disorders on these associations using multivariate logistic models. RESULTS: Exposure to CAs was common, and those who experienced any CAs had increased odds of later PEs [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.9-2.6]. CAs reflecting maladaptive family functioning (MFF), including abuse, neglect, and parent maladjustment, exhibited the strongest associations with PE onset in all life-course stages. Sexual abuse exhibited a strong association with PE onset during childhood (OR 8.5, 95% CI 3.6-20.2), whereas Other CA types were associated with PE onset in adolescence. Associations of other CAs with PEs disappeared in adolescence after adjustment for prior-onset mental disorders. The population attributable risk proportion (PARP) for PEs associated with all CAs was 31% (24% for MFF). CONCLUSIONS: Exposure to CAs is associated with PE onset throughout the life-course, although sexual abuse is most strongly associated with childhood-onset PEs. The presence of mental disorders prior to the onset of PEs does not fully explain these associations. The large PARPs suggest that preventing CAs could lead to a meaningful reduction in PEs in the population.Cambridge University Press2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/120251Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1017/S0033291716003263Psychological Medicine, 2017, vol. 47, num. 7https://doi.org/10.1017/S0033291716003263(c) Cambridge University Press, 2017info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1202512026-05-27T06:46:51Z
dc.title.none.fl_str_mv The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries
title The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries
spellingShingle The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries
McGrath, John J.
Malalties mentals
Infants
Mental illness
Children
title_short The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries
title_full The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries
title_fullStr The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries
title_full_unstemmed The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries
title_sort The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries
dc.creator.none.fl_str_mv McGrath, John J.
McLaughlin, K. A.
Saha, Sukanta
Aguilar-Gaxiola, Sergio
Al-Hamzawi, Ali Obaid
Alonso, Jordi
Bruffaerts, Ronny
Girolamo, Giovanni de
Jonge, Peter de
Esan, O.
Florescu, Silvia E.
Gureje, Oye
Haro Abad, Josep Maria
Hu, Chiyi
Karam, Elie Georges
Kovess-Masfety, Viviane
Lee, Soon Yeun
Lepine, Jean Pierre
Lim, Carmen C. W.
Medina Mora, Maria Elena
Mneimneh, Z.
Pennell, Beth-Ellen
Piazza, Marina
Posada Villa, José
Sampson, Nancy A.
Viana, Maria Carmen
Xavier, Miguel
Bromet, Evelyn J.
Kendler, Kenneth S.
Kessler, Ronald C.
author McGrath, John J.
author_facet McGrath, John J.
McLaughlin, K. A.
Saha, Sukanta
Aguilar-Gaxiola, Sergio
Al-Hamzawi, Ali Obaid
Alonso, Jordi
Bruffaerts, Ronny
Girolamo, Giovanni de
Jonge, Peter de
Esan, O.
Florescu, Silvia E.
Gureje, Oye
Haro Abad, Josep Maria
Hu, Chiyi
Karam, Elie Georges
Kovess-Masfety, Viviane
Lee, Soon Yeun
Lepine, Jean Pierre
Lim, Carmen C. W.
Medina Mora, Maria Elena
Mneimneh, Z.
Pennell, Beth-Ellen
Piazza, Marina
Posada Villa, José
Sampson, Nancy A.
Viana, Maria Carmen
Xavier, Miguel
Bromet, Evelyn J.
Kendler, Kenneth S.
Kessler, Ronald C.
author_role author
author2 McLaughlin, K. A.
Saha, Sukanta
Aguilar-Gaxiola, Sergio
Al-Hamzawi, Ali Obaid
Alonso, Jordi
Bruffaerts, Ronny
Girolamo, Giovanni de
Jonge, Peter de
Esan, O.
Florescu, Silvia E.
Gureje, Oye
Haro Abad, Josep Maria
Hu, Chiyi
Karam, Elie Georges
Kovess-Masfety, Viviane
Lee, Soon Yeun
Lepine, Jean Pierre
Lim, Carmen C. W.
Medina Mora, Maria Elena
Mneimneh, Z.
Pennell, Beth-Ellen
Piazza, Marina
Posada Villa, José
Sampson, Nancy A.
Viana, Maria Carmen
Xavier, Miguel
Bromet, Evelyn J.
Kendler, Kenneth S.
Kessler, Ronald C.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties mentals
Infants
Mental illness
Children
topic Malalties mentals
Infants
Mental illness
Children
description Although there is robust evidence linking childhood adversities (CAs) and an increased risk for psychotic experiences (PEs), little is known about whether these associations vary across the life-course and whether mental disorders that emerge prior to PEs explain these associations. METHOD: We assessed CAs, PEs and DSM-IV mental disorders in 23 998 adults in the WHO World Mental Health Surveys. Discrete-time survival analysis was used to investigate the associations between CAs and PEs, and the influence of mental disorders on these associations using multivariate logistic models. RESULTS: Exposure to CAs was common, and those who experienced any CAs had increased odds of later PEs [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.9-2.6]. CAs reflecting maladaptive family functioning (MFF), including abuse, neglect, and parent maladjustment, exhibited the strongest associations with PE onset in all life-course stages. Sexual abuse exhibited a strong association with PE onset during childhood (OR 8.5, 95% CI 3.6-20.2), whereas Other CA types were associated with PE onset in adolescence. Associations of other CAs with PEs disappeared in adolescence after adjustment for prior-onset mental disorders. The population attributable risk proportion (PARP) for PEs associated with all CAs was 31% (24% for MFF). CONCLUSIONS: Exposure to CAs is associated with PE onset throughout the life-course, although sexual abuse is most strongly associated with childhood-onset PEs. The presence of mental disorders prior to the onset of PEs does not fully explain these associations. The large PARPs suggest that preventing CAs could lead to a meaningful reduction in PEs in the population.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/120251
url https://hdl.handle.net/2445/120251
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1017/S0033291716003263
Psychological Medicine, 2017, vol. 47, num. 7
https://doi.org/10.1017/S0033291716003263
dc.rights.none.fl_str_mv (c) Cambridge University Press, 2017
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Cambridge University Press, 2017
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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