Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin

Calcific aortic stenosis (CAS) and type 2 diabetes mellitus (T2DM) are related and often concomitant pathologies, accompanied by common comorbidities such as hypertension or dyslipidemia. Oxidative stress is one of the mechanisms that trigger CAS, and it can drive the vascular complications in T2DM....

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Autores: Corbacho Alonso, Nerea, Rodríguez Sánchez, Elena, Sastre Oliva, Tamara, Mercado García, Elisa, Perales Sánchez, Ines, Juarez Alia, Cristina, López Almodovar, Luis F., Padial, Luis R., Tejerina, Teresa, Mourino Alvarez, Laura, Ruiz Hurtado, Gema, Barderas, María G.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/718897
Acceso en línea:http://hdl.handle.net/10486/718897
https://dx.doi.org/10.3390/antiox12051024
Access Level:acceso abierto
Palabra clave:antioxidant defense
calcific aortic stenosis
diabetes mellitus
metformin
oxidative stress
Medicina
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spelling Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of MetforminCorbacho Alonso, NereaRodríguez Sánchez, ElenaSastre Oliva, TamaraMercado García, ElisaPerales Sánchez, InesJuarez Alia, CristinaLópez Almodovar, Luis F.Padial, Luis R.Tejerina, TeresaMourino Alvarez, LauraRuiz Hurtado, GemaBarderas, María G.antioxidant defensecalcific aortic stenosisdiabetes mellitusmetforminoxidative stressMedicinaCalcific aortic stenosis (CAS) and type 2 diabetes mellitus (T2DM) are related and often concomitant pathologies, accompanied by common comorbidities such as hypertension or dyslipidemia. Oxidative stress is one of the mechanisms that trigger CAS, and it can drive the vascular complications in T2DM. Metformin can inhibit oxidative stress, yet its effects have not been studied in the context of CAS. Here, we assessed the global oxidative status in plasma from patients with CAS, both alone and with T2DM (and under treatment with metformin), using multimarker scores of systemic oxidative damage (OxyScore) and antioxidant defense (AntioxyScore). The OxyScore was determined by measuring carbonyls, oxidized LDL (oxLDL), 8-hydroxy-20-deoxyguanosine (8-OHdG), and xanthine oxidase (XOD) activity. In contrast, the AntioxyScore was determined through the catalase (CAT) and superoxide dismutase (SOD) activity, as well as the total antioxidant capacity (TAC). Patients with CAS displayed enhanced oxidative stress compared to control subjects, probably exceeding their antioxidant capacity. Interestingly, patients with CAS and T2DM displayed less oxidative stress, possibly due to the benefits of their pharmacological therapy (metformin). Thus, reducing oxidative stress or enhancing antioxidant capacity through specific therapies could be a good strategy to manage CAS, focusing on personalized medicineThis study has been funded by the Instituto de Salud Carlos III through the projects PI18/00995, PI21/00384, PI20/00763, CPII20/00022, and FI18/00261 and co-funded by the European Union #1; the Sociedad Española de Cardiología 2020 #1, Grant PRB3 (IPT17/0019—ISCIIISGEFI/ERDF); SBPLY/19/180501/000226, SBPLY/21/180501/000078, SBPLY/21/180225/000035 funded by the Consejería de Educación Junta de Comunidades de Castilla-La Mancha (JCCM, cofunded by the European Regional Development Fund 2021-2027); and partially by the Spanish Society of Nephrology SEN/SENEFRO Foundation. These results are aligned with the Spanish initiative on the Human Proteome Project (SpHPP). #1 Laboratorio de Fisiopatología Vascular, Fundación del Hospital Nacional de Parapléjicos, Toledo, SpainMDPIDepartamento de FisiologíaFacultad de Medicina20232023-05-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/718897https://dx.doi.org/10.3390/antiox12051024reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7188972026-06-23T12:46:27Z
dc.title.none.fl_str_mv Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
title Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
spellingShingle Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
Corbacho Alonso, Nerea
antioxidant defense
calcific aortic stenosis
diabetes mellitus
metformin
oxidative stress
Medicina
title_short Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
title_full Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
title_fullStr Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
title_full_unstemmed Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
title_sort Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin
dc.creator.none.fl_str_mv Corbacho Alonso, Nerea
Rodríguez Sánchez, Elena
Sastre Oliva, Tamara
Mercado García, Elisa
Perales Sánchez, Ines
Juarez Alia, Cristina
López Almodovar, Luis F.
Padial, Luis R.
Tejerina, Teresa
Mourino Alvarez, Laura
Ruiz Hurtado, Gema
Barderas, María G.
author Corbacho Alonso, Nerea
author_facet Corbacho Alonso, Nerea
Rodríguez Sánchez, Elena
Sastre Oliva, Tamara
Mercado García, Elisa
Perales Sánchez, Ines
Juarez Alia, Cristina
López Almodovar, Luis F.
Padial, Luis R.
Tejerina, Teresa
Mourino Alvarez, Laura
Ruiz Hurtado, Gema
Barderas, María G.
author_role author
author2 Rodríguez Sánchez, Elena
Sastre Oliva, Tamara
Mercado García, Elisa
Perales Sánchez, Ines
Juarez Alia, Cristina
López Almodovar, Luis F.
Padial, Luis R.
Tejerina, Teresa
Mourino Alvarez, Laura
Ruiz Hurtado, Gema
Barderas, María G.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Fisiología
Facultad de Medicina
dc.subject.none.fl_str_mv antioxidant defense
calcific aortic stenosis
diabetes mellitus
metformin
oxidative stress
Medicina
topic antioxidant defense
calcific aortic stenosis
diabetes mellitus
metformin
oxidative stress
Medicina
description Calcific aortic stenosis (CAS) and type 2 diabetes mellitus (T2DM) are related and often concomitant pathologies, accompanied by common comorbidities such as hypertension or dyslipidemia. Oxidative stress is one of the mechanisms that trigger CAS, and it can drive the vascular complications in T2DM. Metformin can inhibit oxidative stress, yet its effects have not been studied in the context of CAS. Here, we assessed the global oxidative status in plasma from patients with CAS, both alone and with T2DM (and under treatment with metformin), using multimarker scores of systemic oxidative damage (OxyScore) and antioxidant defense (AntioxyScore). The OxyScore was determined by measuring carbonyls, oxidized LDL (oxLDL), 8-hydroxy-20-deoxyguanosine (8-OHdG), and xanthine oxidase (XOD) activity. In contrast, the AntioxyScore was determined through the catalase (CAT) and superoxide dismutase (SOD) activity, as well as the total antioxidant capacity (TAC). Patients with CAS displayed enhanced oxidative stress compared to control subjects, probably exceeding their antioxidant capacity. Interestingly, patients with CAS and T2DM displayed less oxidative stress, possibly due to the benefits of their pharmacological therapy (metformin). Thus, reducing oxidative stress or enhancing antioxidant capacity through specific therapies could be a good strategy to manage CAS, focusing on personalized medicine
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-05-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/718897
https://dx.doi.org/10.3390/antiox12051024
url http://hdl.handle.net/10486/718897
https://dx.doi.org/10.3390/antiox12051024
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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