Epidemiological and clinical characteristics of children hospitalized due to influenza A and B in the south of Europe, 2010-2016

Influenza produces annual epidemics that affect 5-15% of the world population. Complications and hospitalizations are more frequent in childhood. This study describes and analyses the epidemiological and clinical characteristics of children hospitalized due to confirmed influenza in influenza survei...

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Autores: Jane, Mireia, Vidal, Maria José, Soldevila, Núria, Romero Tamarit, Arancha, Martínez, Ana, Torner Gràcia, Núria, Godoy, Pere, Launes Montaña, Cristian, Rius, Cristina, Marcos, Ma. Angeles, Domínguez García, Àngela
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/162609
Acesso em linha:https://hdl.handle.net/2445/162609
Access Level:acceso abierto
Palavra-chave:Epidèmies
Infància
Influenzavirus
Epidemics
Childhood
Influenza viruses
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spelling Epidemiological and clinical characteristics of children hospitalized due to influenza A and B in the south of Europe, 2010-2016Jane, MireiaVidal, Maria JoséSoldevila, NúriaRomero Tamarit, AranchaMartínez, AnaTorner Gràcia, NúriaGodoy, PereLaunes Montaña, CristianRius, CristinaMarcos, Ma. AngelesDomínguez García, ÀngelaEpidèmiesInfànciaInfluenzavirusEpidemicsChildhoodInfluenza virusesInfluenza produces annual epidemics that affect 5-15% of the world population. Complications and hospitalizations are more frequent in childhood. This study describes and analyses the epidemiological and clinical characteristics of children hospitalized due to confirmed influenza in influenza surveillance sentinel hospitals in Catalonia. Retrospective descriptive study conducted in six influenza seasons (2010-2011 to 2015-2016) in persons aged 0-17 years diagnosed with laboratory-confirmed influenza requiring hospitalization. 291 cases were notified to the health authorities: 79.4% were due to the influenza A virus and 20.6% to the B virus. The most common subtype was H1N1 with 57.6% of cases: 52.6% were male, 56.7% were aged <2 years, and 24.4% were aged <1 year. 62.2% of cases had pneumonia, 26.8% acute respiratory distress syndrome and 11.7% bacterial pneumonia. 5.8% of cases were vaccinated and 21.3% required intensive care unit admission, of whom 54.8% were aged <2 years. There were 3 deaths, all with influenza A infection. Influenza A cases were younger than influenza B cases (OR 3.22; 95% CI: 1.73-6.00). Conclusion: Children aged <2 years are especially vulnerable to the A H1N1 virus, including those without pre-existing chronic disease. These results are relevant for the planning of vaccination programs to improve maternal and child health.Nature Publishing Group2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/162609Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41598-019-49273-zScientific Reports, 2019, vol. 9, p. 12853https://doi.org/10.1038/s41598-019-49273-zcc-by (c) Jane, Mireia et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1626092026-05-27T06:46:51Z
dc.title.none.fl_str_mv Epidemiological and clinical characteristics of children hospitalized due to influenza A and B in the south of Europe, 2010-2016
title Epidemiological and clinical characteristics of children hospitalized due to influenza A and B in the south of Europe, 2010-2016
spellingShingle Epidemiological and clinical characteristics of children hospitalized due to influenza A and B in the south of Europe, 2010-2016
Jane, Mireia
Epidèmies
Infància
Influenzavirus
Epidemics
Childhood
Influenza viruses
title_short Epidemiological and clinical characteristics of children hospitalized due to influenza A and B in the south of Europe, 2010-2016
title_full Epidemiological and clinical characteristics of children hospitalized due to influenza A and B in the south of Europe, 2010-2016
title_fullStr Epidemiological and clinical characteristics of children hospitalized due to influenza A and B in the south of Europe, 2010-2016
title_full_unstemmed Epidemiological and clinical characteristics of children hospitalized due to influenza A and B in the south of Europe, 2010-2016
title_sort Epidemiological and clinical characteristics of children hospitalized due to influenza A and B in the south of Europe, 2010-2016
dc.creator.none.fl_str_mv Jane, Mireia
Vidal, Maria José
Soldevila, Núria
Romero Tamarit, Arancha
Martínez, Ana
Torner Gràcia, Núria
Godoy, Pere
Launes Montaña, Cristian
Rius, Cristina
Marcos, Ma. Angeles
Domínguez García, Àngela
author Jane, Mireia
author_facet Jane, Mireia
Vidal, Maria José
Soldevila, Núria
Romero Tamarit, Arancha
Martínez, Ana
Torner Gràcia, Núria
Godoy, Pere
Launes Montaña, Cristian
Rius, Cristina
Marcos, Ma. Angeles
Domínguez García, Àngela
author_role author
author2 Vidal, Maria José
Soldevila, Núria
Romero Tamarit, Arancha
Martínez, Ana
Torner Gràcia, Núria
Godoy, Pere
Launes Montaña, Cristian
Rius, Cristina
Marcos, Ma. Angeles
Domínguez García, Àngela
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Epidèmies
Infància
Influenzavirus
Epidemics
Childhood
Influenza viruses
topic Epidèmies
Infància
Influenzavirus
Epidemics
Childhood
Influenza viruses
description Influenza produces annual epidemics that affect 5-15% of the world population. Complications and hospitalizations are more frequent in childhood. This study describes and analyses the epidemiological and clinical characteristics of children hospitalized due to confirmed influenza in influenza surveillance sentinel hospitals in Catalonia. Retrospective descriptive study conducted in six influenza seasons (2010-2011 to 2015-2016) in persons aged 0-17 years diagnosed with laboratory-confirmed influenza requiring hospitalization. 291 cases were notified to the health authorities: 79.4% were due to the influenza A virus and 20.6% to the B virus. The most common subtype was H1N1 with 57.6% of cases: 52.6% were male, 56.7% were aged <2 years, and 24.4% were aged <1 year. 62.2% of cases had pneumonia, 26.8% acute respiratory distress syndrome and 11.7% bacterial pneumonia. 5.8% of cases were vaccinated and 21.3% required intensive care unit admission, of whom 54.8% were aged <2 years. There were 3 deaths, all with influenza A infection. Influenza A cases were younger than influenza B cases (OR 3.22; 95% CI: 1.73-6.00). Conclusion: Children aged <2 years are especially vulnerable to the A H1N1 virus, including those without pre-existing chronic disease. These results are relevant for the planning of vaccination programs to improve maternal and child health.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/162609
url https://hdl.handle.net/2445/162609
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-49273-z
Scientific Reports, 2019, vol. 9, p. 12853
https://doi.org/10.1038/s41598-019-49273-z
dc.rights.none.fl_str_mv cc-by (c) Jane, Mireia et al., 2019
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Jane, Mireia et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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