Treatment of multiple myeloma with renal involvement: the nephrologist's view

Renal injury is a common complication in multiple myeloma (MM). In fact, as many as 10% of patients with MM develop dialysis-dependent acute kidney injury related to increased free light chain (FLC) production by a plasma cell clone. Myeloma cast nephropathy (MCN) is the most prevalent pathologic di...

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Autores: Favà Buch, Alexandre, Fulladosa, Xavier, Montero Pérez, Núria, Draibe, Juliana, Torras Ambròs, Joan, Gomà, Montse, Cruzado, Josep Ma.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/172072
Acceso en línea:https://hdl.handle.net/2445/172072
Access Level:acceso abierto
Palabra clave:Nefrologia
Malalties del ronyó
Nephrology
Kidney diseases
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spelling Treatment of multiple myeloma with renal involvement: the nephrologist's viewFavà Buch, AlexandreFulladosa, XavierMontero Pérez, NúriaDraibe, JulianaTorras Ambròs, JoanGomà, MontseCruzado, Josep Ma.NefrologiaMalalties del ronyóNephrologyKidney diseasesRenal injury is a common complication in multiple myeloma (MM). In fact, as many as 10% of patients with MM develop dialysis-dependent acute kidney injury related to increased free light chain (FLC) production by a plasma cell clone. Myeloma cast nephropathy (MCN) is the most prevalent pathologic diagnosis associated with renal injury, followed by light chain deposition disease and light chain amyloidosis. Several FLC removal techniques have been explored to improve kidney disease in MM but their impact on renal clinical outcomes remains unclear. According to the evidence, high cut-off haemodialysis should be restricted to MM patients on chemotherapy with histological diagnosis of MCN and haemodialysis requirements. From our perspective, more efforts are needed to improve kidney outcomes in patients with MM and renal failure.Oxford University Press2020202020182020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/172072Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1093/ckj/sfy065Clinical Kidney Journal, 2018, vol. 11, num. 6, p. 777-785https://doi.org/10.1093/ckj/sfy065cc-by-nc (c) Favà, Àlex et al., 2018http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1720722026-05-29T05:05:01Z
dc.title.none.fl_str_mv Treatment of multiple myeloma with renal involvement: the nephrologist's view
title Treatment of multiple myeloma with renal involvement: the nephrologist's view
spellingShingle Treatment of multiple myeloma with renal involvement: the nephrologist's view
Favà Buch, Alexandre
Nefrologia
Malalties del ronyó
Nephrology
Kidney diseases
title_short Treatment of multiple myeloma with renal involvement: the nephrologist's view
title_full Treatment of multiple myeloma with renal involvement: the nephrologist's view
title_fullStr Treatment of multiple myeloma with renal involvement: the nephrologist's view
title_full_unstemmed Treatment of multiple myeloma with renal involvement: the nephrologist's view
title_sort Treatment of multiple myeloma with renal involvement: the nephrologist's view
dc.creator.none.fl_str_mv Favà Buch, Alexandre
Fulladosa, Xavier
Montero Pérez, Núria
Draibe, Juliana
Torras Ambròs, Joan
Gomà, Montse
Cruzado, Josep Ma.
author Favà Buch, Alexandre
author_facet Favà Buch, Alexandre
Fulladosa, Xavier
Montero Pérez, Núria
Draibe, Juliana
Torras Ambròs, Joan
Gomà, Montse
Cruzado, Josep Ma.
author_role author
author2 Fulladosa, Xavier
Montero Pérez, Núria
Draibe, Juliana
Torras Ambròs, Joan
Gomà, Montse
Cruzado, Josep Ma.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Nefrologia
Malalties del ronyó
Nephrology
Kidney diseases
topic Nefrologia
Malalties del ronyó
Nephrology
Kidney diseases
description Renal injury is a common complication in multiple myeloma (MM). In fact, as many as 10% of patients with MM develop dialysis-dependent acute kidney injury related to increased free light chain (FLC) production by a plasma cell clone. Myeloma cast nephropathy (MCN) is the most prevalent pathologic diagnosis associated with renal injury, followed by light chain deposition disease and light chain amyloidosis. Several FLC removal techniques have been explored to improve kidney disease in MM but their impact on renal clinical outcomes remains unclear. According to the evidence, high cut-off haemodialysis should be restricted to MM patients on chemotherapy with histological diagnosis of MCN and haemodialysis requirements. From our perspective, more efforts are needed to improve kidney outcomes in patients with MM and renal failure.
publishDate 2018
dc.date.none.fl_str_mv 2018
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172072
url https://hdl.handle.net/2445/172072
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1093/ckj/sfy065
Clinical Kidney Journal, 2018, vol. 11, num. 6, p. 777-785
https://doi.org/10.1093/ckj/sfy065
dc.rights.none.fl_str_mv cc-by-nc (c) Favà, Àlex et al., 2018
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Favà, Àlex et al., 2018
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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