Characterization of COPD Admissions During the First COVID-19 Outbreak

Purpose: Exacerbations of COPD (ECOPD) are a frequent cause of hospitalization that seemed to ameliorate during the COVID outbreak. We aimed to evaluate the clinical characteristics of COPD-related hospital admissions and mortality in relation to the presence of COVID-19. Patients and Methods: We co...

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Autores: García-Cosío, Borja, Shafiek, Hanaa, Toledo Pons, Nuria, Iglesias, Amanda, Barcelo, Margalida, Represas-Represas, Cristina, Comeche, Lorena, Catalan, Pablo, Fernandez-Villar, Alberto, Lopez-Campos, Jose Luis, Echave-Sustaeta, Jose M, Soler-Cataluna, Juan Jose
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/23168
Acceso en línea:https://hdl.handle.net/20.500.12105/23168
Access Level:acceso abierto
Palabra clave:COPD exacerbation
Mortality
Inhaled corticosteroids
Hospitalization
Enfermedad Pulmonar Obstructiva Crónica
Humanos
SARS-CoV-2
COVID-19
Hospitalización
España
Estudios de Casos y Controles
Brotes de Enfermedades
Masculino
Male
Case-Control Studies
Disease Outbreaks
Spain
Pulmonary Disease, Chronic Obstructive
Humans
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network_acronym_str ES
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repository_id_str
spelling Characterization of COPD Admissions During the First COVID-19 OutbreakGarcía-Cosío, BorjaShafiek, HanaaToledo Pons, NuriaIglesias, AmandaBarcelo, MargalidaRepresas-Represas, CristinaComeche, LorenaCatalan, PabloFernandez-Villar, AlbertoLopez-Campos, Jose LuisEchave-Sustaeta, Jose MSoler-Cataluna, Juan JoseCOPD exacerbationMortalityInhaled corticosteroidsHospitalizationEnfermedad Pulmonar Obstructiva CrónicaHumanosSARS-CoV-2COVID-19HospitalizaciónEspañaEstudios de Casos y ControlesBrotes de EnfermedadesMasculinoHospitalizationMaleCase-Control StudiesDisease OutbreaksSARS-CoV-2SpainPulmonary Disease, Chronic ObstructiveHumansCOVID-19Purpose: Exacerbations of COPD (ECOPD) are a frequent cause of hospitalization that seemed to ameliorate during the COVID outbreak. We aimed to evaluate the clinical characteristics of COPD-related hospital admissions and mortality in relation to the presence of COVID-19. Patients and Methods: We conducted a case-control study of patients admitted in four teaching hospitals throughout Spain between March 15 and April 30, 2020. Hospital admissions of respiratory cause with and without PCR-proven SARS-CoV-2 infection in patients with COPD were evaluated. Baseline and episode-related clinical characteristics were analyzed. Logistic regression analysis was performed to evaluate the risk for mortality. Results: During the study period, 2101 patients were admitted for respiratory worsening, 1200 (57.1%) with COVID-19. A total of 228 (10.8%) were admitted due to COPD worsening, of whom 52 (22.8%) tested positive for COVID-19. COPD patients with COVID-19, when compared to those without COVID-19, were more frequently males with better lung function (FEV1 postbronchodilator 71% vs 46% respectively, p<0.001) and had higher mortality (44.9% vs 13.6% respectively, p<0.001) despite similar age, comorbidities, total days of hospitalization and admission to intensive care unit. COVID-19 and eosinopenia were the strongest risk factors for mortality in the multivariate analysis in the overall COPD population. Inhaled corticosteroid use was not associated to mortality. Conclusion: Hospitalizations for ECOPD without COVID-19 were more frequent than COPD with COVID-19 during the first outbreak, but the latter were associated with higher mortality and low eosinophil counts that warrant further analysis.Dove Medical Press20242024-09-1820212021-01-0120212021-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/23168reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/231682026-06-12T12:43:37Z
dc.title.none.fl_str_mv Characterization of COPD Admissions During the First COVID-19 Outbreak
title Characterization of COPD Admissions During the First COVID-19 Outbreak
spellingShingle Characterization of COPD Admissions During the First COVID-19 Outbreak
García-Cosío, Borja
COPD exacerbation
Mortality
Inhaled corticosteroids
Hospitalization
Enfermedad Pulmonar Obstructiva Crónica
Humanos
SARS-CoV-2
COVID-19
Hospitalización
España
Estudios de Casos y Controles
Brotes de Enfermedades
Masculino
Hospitalization
Male
Case-Control Studies
Disease Outbreaks
SARS-CoV-2
Spain
Pulmonary Disease, Chronic Obstructive
Humans
COVID-19
title_short Characterization of COPD Admissions During the First COVID-19 Outbreak
title_full Characterization of COPD Admissions During the First COVID-19 Outbreak
title_fullStr Characterization of COPD Admissions During the First COVID-19 Outbreak
title_full_unstemmed Characterization of COPD Admissions During the First COVID-19 Outbreak
title_sort Characterization of COPD Admissions During the First COVID-19 Outbreak
dc.creator.none.fl_str_mv García-Cosío, Borja
Shafiek, Hanaa
Toledo Pons, Nuria
Iglesias, Amanda
Barcelo, Margalida
Represas-Represas, Cristina
Comeche, Lorena
Catalan, Pablo
Fernandez-Villar, Alberto
Lopez-Campos, Jose Luis
Echave-Sustaeta, Jose M
Soler-Cataluna, Juan Jose
author García-Cosío, Borja
author_facet García-Cosío, Borja
Shafiek, Hanaa
Toledo Pons, Nuria
Iglesias, Amanda
Barcelo, Margalida
Represas-Represas, Cristina
Comeche, Lorena
Catalan, Pablo
Fernandez-Villar, Alberto
Lopez-Campos, Jose Luis
Echave-Sustaeta, Jose M
Soler-Cataluna, Juan Jose
author_role author
author2 Shafiek, Hanaa
Toledo Pons, Nuria
Iglesias, Amanda
Barcelo, Margalida
Represas-Represas, Cristina
Comeche, Lorena
Catalan, Pablo
Fernandez-Villar, Alberto
Lopez-Campos, Jose Luis
Echave-Sustaeta, Jose M
Soler-Cataluna, Juan Jose
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv COPD exacerbation
Mortality
Inhaled corticosteroids
Hospitalization
Enfermedad Pulmonar Obstructiva Crónica
Humanos
SARS-CoV-2
COVID-19
Hospitalización
España
Estudios de Casos y Controles
Brotes de Enfermedades
Masculino
Hospitalization
Male
Case-Control Studies
Disease Outbreaks
SARS-CoV-2
Spain
Pulmonary Disease, Chronic Obstructive
Humans
COVID-19
topic COPD exacerbation
Mortality
Inhaled corticosteroids
Hospitalization
Enfermedad Pulmonar Obstructiva Crónica
Humanos
SARS-CoV-2
COVID-19
Hospitalización
España
Estudios de Casos y Controles
Brotes de Enfermedades
Masculino
Hospitalization
Male
Case-Control Studies
Disease Outbreaks
SARS-CoV-2
Spain
Pulmonary Disease, Chronic Obstructive
Humans
COVID-19
description Purpose: Exacerbations of COPD (ECOPD) are a frequent cause of hospitalization that seemed to ameliorate during the COVID outbreak. We aimed to evaluate the clinical characteristics of COPD-related hospital admissions and mortality in relation to the presence of COVID-19. Patients and Methods: We conducted a case-control study of patients admitted in four teaching hospitals throughout Spain between March 15 and April 30, 2020. Hospital admissions of respiratory cause with and without PCR-proven SARS-CoV-2 infection in patients with COPD were evaluated. Baseline and episode-related clinical characteristics were analyzed. Logistic regression analysis was performed to evaluate the risk for mortality. Results: During the study period, 2101 patients were admitted for respiratory worsening, 1200 (57.1%) with COVID-19. A total of 228 (10.8%) were admitted due to COPD worsening, of whom 52 (22.8%) tested positive for COVID-19. COPD patients with COVID-19, when compared to those without COVID-19, were more frequently males with better lung function (FEV1 postbronchodilator 71% vs 46% respectively, p<0.001) and had higher mortality (44.9% vs 13.6% respectively, p<0.001) despite similar age, comorbidities, total days of hospitalization and admission to intensive care unit. COVID-19 and eosinopenia were the strongest risk factors for mortality in the multivariate analysis in the overall COPD population. Inhaled corticosteroid use was not associated to mortality. Conclusion: Hospitalizations for ECOPD without COVID-19 were more frequent than COPD with COVID-19 during the first outbreak, but the latter were associated with higher mortality and low eosinophil counts that warrant further analysis.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
2024
2024-09-18
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/23168
url https://hdl.handle.net/20.500.12105/23168
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Dove Medical Press
publisher.none.fl_str_mv Dove Medical Press
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414083980165120
score 15,812429

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