Dietary inflammatory index and incidence of cardiovascular disease in the SUN cohort
BACKGROUND: Diet is known to play a key role in atherogenesis and in the development of cardiovascular events. Dietary factors may mediate these processes acting as potential modulators of inflammation. Potential Links between inflammatory properties of diet and the occurrence of cardiovascular even...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/39020 |
| Acceso en línea: | https://hdl.handle.net/10171/39020 |
| Access Level: | acceso abierto |
| Palabra clave: | SUN cohort Diet Inflammatory biomarkers |
| id |
ES_976c7a77e28e3dee80daec2a208f1426 |
|---|---|
| oai_identifier_str |
oai:dadun.unav.edu:10171/39020 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Dietary inflammatory index and incidence of cardiovascular disease in the SUN cohortRamallal, R. (Raul)|||/items/f956c97d-efb5-4df8-9115-b0a770fb2782Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7Hernandez-Hernandez, A. (Aitor)|||/items/a9dcb96d-265e-4e9b-b5fb-f5a88039c189Garcia-Arellano, A. (Ana)|||/items/b617b8f4-1560-4373-9ceb-6aff54d2e497Shivappa, N. (Nitin)|||/items/bf543366-9205-4d81-a346-f799af38db17Hebert, J.R. (James R.)|||/items/17b5bdcb-8e09-4860-a2f9-086cbc15a619Ruiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9SUN cohortDietInflammatory biomarkersBACKGROUND: Diet is known to play a key role in atherogenesis and in the development of cardiovascular events. Dietary factors may mediate these processes acting as potential modulators of inflammation. Potential Links between inflammatory properties of diet and the occurrence of cardiovascular events have not been tested previously. OBJECTIVE: We aimed to assess the association between the dietary inflammatory index (DII), a method to assess the inflammatory potential of the diet, and incident cardiovascular disease. METHODS: In the prospective, dynamic SUN cohort, 18,794 middle-aged, Spanish university graduates were followed up for 8.9 years (median). A validated 136-item food-frequency questionnaire was used to calculate the DII. The DII is based on scientific evidence about the relationship between diet and inflammatory biomarkers (C-reactive protein, IL-1β, IL-4, IL-6, IL-10 and TNF-α). Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between the DII and incident cardiovascular disease (myocardial infarction, stroke or cardiovascular death). RESULTS: The risk for cardiovascular events progressively increased with each increasing quartile of DII (ptrend = 0.017). The multivariable-adjusted HR for participants in the highest (most pro-inflammatory) vs. the lowest quartile of the DII was 2.03 (95% CI 1.06-3.88). CONCLUSIONS: A pro-inflammatory diet was associated with a significantly higher risk for developing cardiovascular events.Public Library of ScienceDadun. Depósito Académico Digital Universidad de Navarra20152015-09-1620152015-01-0120152015-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/39020reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/390202026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Dietary inflammatory index and incidence of cardiovascular disease in the SUN cohort |
| title |
Dietary inflammatory index and incidence of cardiovascular disease in the SUN cohort |
| spellingShingle |
Dietary inflammatory index and incidence of cardiovascular disease in the SUN cohort Ramallal, R. (Raul)|||/items/f956c97d-efb5-4df8-9115-b0a770fb2782 SUN cohort Diet Inflammatory biomarkers |
| title_short |
Dietary inflammatory index and incidence of cardiovascular disease in the SUN cohort |
| title_full |
Dietary inflammatory index and incidence of cardiovascular disease in the SUN cohort |
| title_fullStr |
Dietary inflammatory index and incidence of cardiovascular disease in the SUN cohort |
| title_full_unstemmed |
Dietary inflammatory index and incidence of cardiovascular disease in the SUN cohort |
| title_sort |
Dietary inflammatory index and incidence of cardiovascular disease in the SUN cohort |
| dc.creator.none.fl_str_mv |
Ramallal, R. (Raul)|||/items/f956c97d-efb5-4df8-9115-b0a770fb2782 Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Hernandez-Hernandez, A. (Aitor)|||/items/a9dcb96d-265e-4e9b-b5fb-f5a88039c189 Garcia-Arellano, A. (Ana)|||/items/b617b8f4-1560-4373-9ceb-6aff54d2e497 Shivappa, N. (Nitin)|||/items/bf543366-9205-4d81-a346-f799af38db17 Hebert, J.R. (James R.)|||/items/17b5bdcb-8e09-4860-a2f9-086cbc15a619 Ruiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9 |
| author |
Ramallal, R. (Raul)|||/items/f956c97d-efb5-4df8-9115-b0a770fb2782 |
| author_facet |
Ramallal, R. (Raul)|||/items/f956c97d-efb5-4df8-9115-b0a770fb2782 Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Hernandez-Hernandez, A. (Aitor)|||/items/a9dcb96d-265e-4e9b-b5fb-f5a88039c189 Garcia-Arellano, A. (Ana)|||/items/b617b8f4-1560-4373-9ceb-6aff54d2e497 Shivappa, N. (Nitin)|||/items/bf543366-9205-4d81-a346-f799af38db17 Hebert, J.R. (James R.)|||/items/17b5bdcb-8e09-4860-a2f9-086cbc15a619 Ruiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9 |
| author_role |
author |
| author2 |
Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Hernandez-Hernandez, A. (Aitor)|||/items/a9dcb96d-265e-4e9b-b5fb-f5a88039c189 Garcia-Arellano, A. (Ana)|||/items/b617b8f4-1560-4373-9ceb-6aff54d2e497 Shivappa, N. (Nitin)|||/items/bf543366-9205-4d81-a346-f799af38db17 Hebert, J.R. (James R.)|||/items/17b5bdcb-8e09-4860-a2f9-086cbc15a619 Ruiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9 |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
SUN cohort Diet Inflammatory biomarkers |
| topic |
SUN cohort Diet Inflammatory biomarkers |
| description |
BACKGROUND: Diet is known to play a key role in atherogenesis and in the development of cardiovascular events. Dietary factors may mediate these processes acting as potential modulators of inflammation. Potential Links between inflammatory properties of diet and the occurrence of cardiovascular events have not been tested previously. OBJECTIVE: We aimed to assess the association between the dietary inflammatory index (DII), a method to assess the inflammatory potential of the diet, and incident cardiovascular disease. METHODS: In the prospective, dynamic SUN cohort, 18,794 middle-aged, Spanish university graduates were followed up for 8.9 years (median). A validated 136-item food-frequency questionnaire was used to calculate the DII. The DII is based on scientific evidence about the relationship between diet and inflammatory biomarkers (C-reactive protein, IL-1β, IL-4, IL-6, IL-10 and TNF-α). Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between the DII and incident cardiovascular disease (myocardial infarction, stroke or cardiovascular death). RESULTS: The risk for cardiovascular events progressively increased with each increasing quartile of DII (ptrend = 0.017). The multivariable-adjusted HR for participants in the highest (most pro-inflammatory) vs. the lowest quartile of the DII was 2.03 (95% CI 1.06-3.88). CONCLUSIONS: A pro-inflammatory diet was associated with a significantly higher risk for developing cardiovascular events. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 2015-09-16 2015 2015-01-01 2015 2015-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/39020 |
| url |
https://hdl.handle.net/10171/39020 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Public Library of Science |
| publisher.none.fl_str_mv |
Public Library of Science |
| dc.source.none.fl_str_mv |
reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
| instname_str |
Universidad de Navarra |
| reponame_str |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| collection |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869414078198317056 |
| score |
15,300724 |