1988-2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research

In 1988, two unrelated papers reported the discovery of peptide vectors with innate cell translocation properties, setting the ground for a new area of research that over the years has grown into considerable therapeutic potential. The vectors, named cell-penetrating peptides (CPPs), constitute a no...

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Detalles Bibliográficos
Autores: Gallo, María, 1989-, Defaus, Sira, Andreu Martínez, David
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/71681
Acceso en línea:http://hdl.handle.net/10230/71681
http://dx.doi.org/10.1016/j.abb.2018.11.010
Access Level:acceso abierto
Palabra clave:Cell-penetrating peptides
Drug delivery
Blood-brain barrier
Trans-membrane helix cross-talk disruptor peptides
Anti-parasitic drugs
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spelling 1988-2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical researchGallo, María, 1989-Defaus, SiraAndreu Martínez, DavidCell-penetrating peptidesDrug deliveryBlood-brain barrierTrans-membrane helix cross-talk disruptor peptidesAnti-parasitic drugsIn 1988, two unrelated papers reported the discovery of peptide vectors with innate cell translocation properties, setting the ground for a new area of research that over the years has grown into considerable therapeutic potential. The vectors, named cell-penetrating peptides (CPPs), constitute a now large and diversified family, sharing the extraordinary ability to diffuse unaltered across cell membranes while ferrying diverse associated cargos. Such properties have made CPPs ideal tools for delivery of nucleic acids, proteins and other therapeutic/diagnostic molecules to cells and tissues via covalent conjugation or complexation. This year 2018 marks the 30th anniversary of a peptide research landmark opening new perspectives in drug delivery. Given its vastness, exhaustive coverage of the main features and accomplishments in the CPP field is virtually impossible. Hence this manuscript, after saluting the above 30th jubilee, focuses by necessity on the most recent contributions, providing a comprehensive list of recognized CPPs and their latest-reported applications over the last two years. In addition, it thoroughly reviews three areas of peptide vector research of particular interest to us, namely (i) efficient transport of low-bioavailability drugs into the brain; (ii) CPP-delivered disruptors of G protein-coupled receptor (GPCRs) heteromers related to several disorders, and (iii) CPP-mediated delivery of useful but poorly internalized drugs into parasites.Work supported by the Spanish Ministry of Economy and Competitiveness (MINECO), grants SAF2011-24899 and AGL2014-52395-C2 (to D.A.) and “María de Maeztu” Program for Units of Excellence in R&D (to Pompeu Fabra University). Additional support from the EU Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) grant 644167, 2015–2019 (D.A. & S.D.).Elsevier2025202520192025info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/71681http://dx.doi.org/10.1016/j.abb.2018.11.010http://hdl.handle.net/10230/71681reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésArchives of Biochemistry and Biophysics. 2019;661:74-86info:eu-repo/grantAgreement/ES/3PN/SAF2011-24899info:eu-repo/grantAgreement/ES/1PE/AGL2014-52395-C2info:eu-repo/grantAgreement/EC/H2020/644167© Elsevier http://dx.doi.org/10.1016/j.abb.2018.11.010info:eu-repo/semantics/openAccessoai:recercat.cat:10230/716812026-05-29T05:05:01Z
dc.title.none.fl_str_mv 1988-2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research
title 1988-2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research
spellingShingle 1988-2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research
Gallo, María, 1989-
Cell-penetrating peptides
Drug delivery
Blood-brain barrier
Trans-membrane helix cross-talk disruptor peptides
Anti-parasitic drugs
title_short 1988-2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research
title_full 1988-2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research
title_fullStr 1988-2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research
title_full_unstemmed 1988-2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research
title_sort 1988-2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research
dc.creator.none.fl_str_mv Gallo, María, 1989-
Defaus, Sira
Andreu Martínez, David
author Gallo, María, 1989-
author_facet Gallo, María, 1989-
Defaus, Sira
Andreu Martínez, David
author_role author
author2 Defaus, Sira
Andreu Martínez, David
author2_role author
author
dc.subject.none.fl_str_mv Cell-penetrating peptides
Drug delivery
Blood-brain barrier
Trans-membrane helix cross-talk disruptor peptides
Anti-parasitic drugs
topic Cell-penetrating peptides
Drug delivery
Blood-brain barrier
Trans-membrane helix cross-talk disruptor peptides
Anti-parasitic drugs
description In 1988, two unrelated papers reported the discovery of peptide vectors with innate cell translocation properties, setting the ground for a new area of research that over the years has grown into considerable therapeutic potential. The vectors, named cell-penetrating peptides (CPPs), constitute a now large and diversified family, sharing the extraordinary ability to diffuse unaltered across cell membranes while ferrying diverse associated cargos. Such properties have made CPPs ideal tools for delivery of nucleic acids, proteins and other therapeutic/diagnostic molecules to cells and tissues via covalent conjugation or complexation. This year 2018 marks the 30th anniversary of a peptide research landmark opening new perspectives in drug delivery. Given its vastness, exhaustive coverage of the main features and accomplishments in the CPP field is virtually impossible. Hence this manuscript, after saluting the above 30th jubilee, focuses by necessity on the most recent contributions, providing a comprehensive list of recognized CPPs and their latest-reported applications over the last two years. In addition, it thoroughly reviews three areas of peptide vector research of particular interest to us, namely (i) efficient transport of low-bioavailability drugs into the brain; (ii) CPP-delivered disruptors of G protein-coupled receptor (GPCRs) heteromers related to several disorders, and (iii) CPP-mediated delivery of useful but poorly internalized drugs into parasites.
publishDate 2019
dc.date.none.fl_str_mv 2019
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/71681
http://dx.doi.org/10.1016/j.abb.2018.11.010
http://hdl.handle.net/10230/71681
url http://hdl.handle.net/10230/71681
http://dx.doi.org/10.1016/j.abb.2018.11.010
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Archives of Biochemistry and Biophysics. 2019;661:74-86
info:eu-repo/grantAgreement/ES/3PN/SAF2011-24899
info:eu-repo/grantAgreement/ES/1PE/AGL2014-52395-C2
info:eu-repo/grantAgreement/EC/H2020/644167
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.abb.2018.11.010
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.abb.2018.11.010
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
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