A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation

Efficient drug delivery across the blood–brain barrier (BBB) remains a significant obstacle in treating central nervous system (CNS) disorders. This review provides an in-depth analysis of the structural and molecular mechanisms underlying BBB integrity and its functional properties. We detail the r...

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Detalhes bibliográficos
Autores: Porro, Giulia Maria, Basile, Marco, Xie, Zhendong, Tuveri, Gianmarco, Battaglia, Giuseppe, Carvalho Ferreira Lopes, Cátia Daniela
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/222241
Acesso em linha:https://hdl.handle.net/2445/222241
Access Level:acceso abierto
Palavra-chave:Neurofarmacologia
Farmacocinètica
Barrera hematoencefàlica
Neuropharmacology
Pharmacokinetics
Blood-brain barrier
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spelling A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeationPorro, Giulia MariaBasile, MarcoXie, ZhendongTuveri, GianmarcoBattaglia, GiuseppeCarvalho Ferreira Lopes, Cátia DanielaNeurofarmacologiaFarmacocinèticaBarrera hematoencefàlicaNeuropharmacologyPharmacokineticsBlood-brain barrierEfficient drug delivery across the blood–brain barrier (BBB) remains a significant obstacle in treating central nervous system (CNS) disorders. This review provides an in-depth analysis of the structural and molecular mechanisms underlying BBB integrity and its functional properties. We detail the role of key cellular and molecular components that regulate selective molecular transport across the barrier, alongside a description of the current therapeutic approaches for brain drug delivery, including those leveraging receptor-mediated transcytosis. Emphasis is placed on multivalency-based strategies that enhance the specificity of nanoparticle targeting and improve transport efficacy across the BBB. Additionally, we discuss the added value of integrating mathematical and computational models with experimental validation for accelerating BBB-targeted delivery systems optimisation.Elsevier2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion18 p.application/pdfhttps://hdl.handle.net/2445/222241Articles publicats en revistes (Física de la Matèria Condensada)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.addr.2025.115637Advanced Drug Delivery Reviews, 2025, vol. 224, 115637https://doi.org/10.1016/j.addr.2025.115637cc-by (c) Porro, Giulia Maria et al., 2025http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2222412026-05-29T05:05:01Z
dc.title.none.fl_str_mv A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation
title A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation
spellingShingle A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation
Porro, Giulia Maria
Neurofarmacologia
Farmacocinètica
Barrera hematoencefàlica
Neuropharmacology
Pharmacokinetics
Blood-brain barrier
title_short A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation
title_full A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation
title_fullStr A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation
title_full_unstemmed A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation
title_sort A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation
dc.creator.none.fl_str_mv Porro, Giulia Maria
Basile, Marco
Xie, Zhendong
Tuveri, Gianmarco
Battaglia, Giuseppe
Carvalho Ferreira Lopes, Cátia Daniela
author Porro, Giulia Maria
author_facet Porro, Giulia Maria
Basile, Marco
Xie, Zhendong
Tuveri, Gianmarco
Battaglia, Giuseppe
Carvalho Ferreira Lopes, Cátia Daniela
author_role author
author2 Basile, Marco
Xie, Zhendong
Tuveri, Gianmarco
Battaglia, Giuseppe
Carvalho Ferreira Lopes, Cátia Daniela
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Neurofarmacologia
Farmacocinètica
Barrera hematoencefàlica
Neuropharmacology
Pharmacokinetics
Blood-brain barrier
topic Neurofarmacologia
Farmacocinètica
Barrera hematoencefàlica
Neuropharmacology
Pharmacokinetics
Blood-brain barrier
description Efficient drug delivery across the blood–brain barrier (BBB) remains a significant obstacle in treating central nervous system (CNS) disorders. This review provides an in-depth analysis of the structural and molecular mechanisms underlying BBB integrity and its functional properties. We detail the role of key cellular and molecular components that regulate selective molecular transport across the barrier, alongside a description of the current therapeutic approaches for brain drug delivery, including those leveraging receptor-mediated transcytosis. Emphasis is placed on multivalency-based strategies that enhance the specificity of nanoparticle targeting and improve transport efficacy across the BBB. Additionally, we discuss the added value of integrating mathematical and computational models with experimental validation for accelerating BBB-targeted delivery systems optimisation.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/222241
url https://hdl.handle.net/2445/222241
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.addr.2025.115637
Advanced Drug Delivery Reviews, 2025, vol. 224, 115637
https://doi.org/10.1016/j.addr.2025.115637
dc.rights.none.fl_str_mv cc-by (c) Porro, Giulia Maria et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Porro, Giulia Maria et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 18 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Física de la Matèria Condensada)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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