A prospective study of lung disease in a cohort of early rheumatoid arthritis patients

Lung disease is common in patients with rheumatoid arthritis (RA). The onset of lung involvement in RA is not well known. The objective is to describe the features and evolution of lung involvement in early RA, its relationship with disease activity parameters, smoking and treatments. Consecutive pa...

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Autores: Robles-Pérez, Alejandro, Luburich Hernaiz, Patricio, Bolívar Cuevas, Santiago, Dorca i Sargatal, Jordi, Nolla Solé, Joan Miquel, Molina Molina, María, Narváez García, Francisco Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/172598
Acceso en línea:https://hdl.handle.net/2445/172598
Access Level:acceso abierto
Palabra clave:Pulmó
Artritis reumatoide
Atenció precoç
Lung
Rheumatoid arthritis
Early intervention (Education)
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spelling A prospective study of lung disease in a cohort of early rheumatoid arthritis patientsRobles-Pérez, AlejandroLuburich Hernaiz, PatricioBolívar Cuevas, SantiagoDorca i Sargatal, JordiNolla Solé, Joan MiquelMolina Molina, MaríaNarváez García, Francisco JavierPulmóArtritis reumatoideAtenció precoçLungRheumatoid arthritisEarly intervention (Education)Lung disease is common in patients with rheumatoid arthritis (RA). The onset of lung involvement in RA is not well known. The objective is to describe the features and evolution of lung involvement in early RA, its relationship with disease activity parameters, smoking and treatments. Consecutive patients with early RA without respiratory symptoms were included and tracked for 5 years. Lung assessment included clinical, radiological and pulmonary function tests at diagnosis and during follow-up. Peripheral blood parameters (erythrocyte sedimentation rate, C reactive protein, rheumatoid factor and anti-citrullinated peptide autoantibodies) and scales of articular involvement, such as DAS28-CRP, were evaluated. 40 patients were included and 32 completed the 5-year follow up. 13 patients presented lung involvement in the initial 5 years after RA diagnosis, 3 of them interstitial lung disease. Significant decrease of diffusion lung transfer capacity of carbon monoxide over time was observed in six patients, 2 of them developed interstitial lung disease. DLCO decrease was correlated with higher values of CRP and ESR at diagnosis. Methotrexate was not associated with DLCO deterioration or lung disease development. Subclinical progressive lung disease correlates with RA activity parameters. Smoking status and methotrexate were not associated with development or progression of lung disease.Nature Publishing Group2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/172598Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41598-020-72768-zScientific Reports, 2020, vol. 10 , num. 1, p. 15640https://doi.org/10.1038/s41598-020-72768-zcc-by (c) Robles-Pérez, Alejandro et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1725982026-05-27T06:46:51Z
dc.title.none.fl_str_mv A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
title A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
spellingShingle A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
Robles-Pérez, Alejandro
Pulmó
Artritis reumatoide
Atenció precoç
Lung
Rheumatoid arthritis
Early intervention (Education)
title_short A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
title_full A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
title_fullStr A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
title_full_unstemmed A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
title_sort A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
dc.creator.none.fl_str_mv Robles-Pérez, Alejandro
Luburich Hernaiz, Patricio
Bolívar Cuevas, Santiago
Dorca i Sargatal, Jordi
Nolla Solé, Joan Miquel
Molina Molina, María
Narváez García, Francisco Javier
author Robles-Pérez, Alejandro
author_facet Robles-Pérez, Alejandro
Luburich Hernaiz, Patricio
Bolívar Cuevas, Santiago
Dorca i Sargatal, Jordi
Nolla Solé, Joan Miquel
Molina Molina, María
Narváez García, Francisco Javier
author_role author
author2 Luburich Hernaiz, Patricio
Bolívar Cuevas, Santiago
Dorca i Sargatal, Jordi
Nolla Solé, Joan Miquel
Molina Molina, María
Narváez García, Francisco Javier
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Pulmó
Artritis reumatoide
Atenció precoç
Lung
Rheumatoid arthritis
Early intervention (Education)
topic Pulmó
Artritis reumatoide
Atenció precoç
Lung
Rheumatoid arthritis
Early intervention (Education)
description Lung disease is common in patients with rheumatoid arthritis (RA). The onset of lung involvement in RA is not well known. The objective is to describe the features and evolution of lung involvement in early RA, its relationship with disease activity parameters, smoking and treatments. Consecutive patients with early RA without respiratory symptoms were included and tracked for 5 years. Lung assessment included clinical, radiological and pulmonary function tests at diagnosis and during follow-up. Peripheral blood parameters (erythrocyte sedimentation rate, C reactive protein, rheumatoid factor and anti-citrullinated peptide autoantibodies) and scales of articular involvement, such as DAS28-CRP, were evaluated. 40 patients were included and 32 completed the 5-year follow up. 13 patients presented lung involvement in the initial 5 years after RA diagnosis, 3 of them interstitial lung disease. Significant decrease of diffusion lung transfer capacity of carbon monoxide over time was observed in six patients, 2 of them developed interstitial lung disease. DLCO decrease was correlated with higher values of CRP and ESR at diagnosis. Methotrexate was not associated with DLCO deterioration or lung disease development. Subclinical progressive lung disease correlates with RA activity parameters. Smoking status and methotrexate were not associated with development or progression of lung disease.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172598
url https://hdl.handle.net/2445/172598
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-72768-z
Scientific Reports, 2020, vol. 10 , num. 1, p. 15640
https://doi.org/10.1038/s41598-020-72768-z
dc.rights.none.fl_str_mv cc-by (c) Robles-Pérez, Alejandro et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Robles-Pérez, Alejandro et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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