Use of epidemiological analytic tools and molecular characterization techniques to inform bovine tuberculosis eradication programs
Bovine tuberculosis (bTB) is an infectious disease with a complex epidemiology at the human-animal-environment interface which, despite the application of extensive control measures, is still prevalent in livestock and wildlife in several regions of Spain. The disease, caused by Mycobacterium bovis...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | español |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/11387 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/11387 |
| Access Level: | acceso abierto |
| Palabra clave: | 636:616.24-002.5(043.2) Tuberculosis in cattle Tuberculosis en el ganado vacuno Ganado vacuno 3104.07 Ovinos |
| Sumario: | Bovine tuberculosis (bTB) is an infectious disease with a complex epidemiology at the human-animal-environment interface which, despite the application of extensive control measures, is still prevalent in livestock and wildlife in several regions of Spain. The disease, caused by Mycobacterium bovis (and to a lesser extent M. caprae), remains a concern due to its negative impact on animal health and welfare, together with the important consequences for production and animal trade that its presence imposes. Eradication programs of bTB in cattle in Spain are based on a combination of regular test and slaughter policies using mostly the single intradermal test (SIT), the interferon-gamma (IFN-γ) assay as an ancillary test in infected herds, and abattoir post-mortem inspection. Disease eradication at the herd level is challenging due to several factors including the limitations in the sensitivity of available diagnostic techniques, the risk of introduction of undetected infected animals, the proximity to positive farms, and the contact with infected wildlife reservoirs. This thesis is based on the application of different analytic tools such as social network analysis, epidemiological models and whole genome sequencing (WGS) to quantify the relative importance of risk factors impairing disease control in Spain using a multidisciplinary approach... |
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