Distinct Physical Properties of β-Hematin in Two Synthetic Media: Compelling Evidence

16 pages, 10 figures, 12 tables

Detalles Bibliográficos
Autores: Herrera, Julieth, García, Karen Edilma, Perez, Valentina, Marco, J.F., Barrero Meneses, César
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/387206
Acceso en línea:http://hdl.handle.net/10261/387206
https://api.elsevier.com/content/abstract/scopus_id/105000433558
Access Level:acceso abierto
Palabra clave:http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
id ES_970d841e028b331eaffd0084cf2409a2
oai_identifier_str oai:digital.csic.es:10261/387206
network_acronym_str ES
network_name_str España
repository_id_str
spelling Distinct Physical Properties of β-Hematin in Two Synthetic Media: Compelling EvidenceHerrera, JuliethGarcía, Karen EdilmaPerez, ValentinaMarco, J.F.Barrero Meneses, Césarhttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all ages16 pages, 10 figures, 12 tablesIt is now widely accepted that detailed knowledge of the physicochemical characteristics of the β-hematin crystals, i.e., the synthetic versions of the natural hemozoin crystals, is important for understanding their formation, the design of antimalarial medicines, and malarial diagnosis. We report that the overall physical properties exhibited by β-hematins greatly depend on the synthetic media. Here, we synthesize β-hematin from hemin in aqueous-acetate and in aqueous-oily media and characterize their properties by several techniques. Infrared spectra clearly demonstrate the formation of β-hematin in both media. The β-hematin crystals prepared in aqueous-acetate are composed by needle-like particles with average lengths around 760-770 nm; their lattice parameters and unit cell volumes are larger than those reported in the literature. They are paramagnetic at 300 K and antiferromagnetic at very low temperatures. Their Mössbauer spectra at 298 K, 77 K, and 10 K are consistent with the presence of high-spin Fe (III) and are less asymmetric as a result of the occurrence of fast spin-spin relaxation time, and their surface composition is complex, showing the presence of a multiplicity of iron oxidation and spin states (although with a majority of high-spin Fe3+ ions). In comparison, the β-hematin crystals prepared in aqueous-oily medium have significantly smaller lengths (ca. 560 nm) and slightly larger unit cell volume in comparison to the previous sample. The magnetic measurements show that they are affected by superparamagnetism and paramagnetism at 298 K and the coexistence of weakly ferromagnetic or possibly ferrimagnetic and paramagnetic phases at 80 K. Their Mössbauer spectra at 298 K, 77 K, and 10 K, also consistent with the presence of high-spin Fe (III), show longer spin-spin relaxation times, and their surface composition is also complex containing less surface OH- groups and higher amounts of Fe (II) ions in low- and high-spin states. The observed differences are discussed in relation to the specific formation conditions present in the synthesis medium. The results reported here are of outmost importance for understanding how the physicochemical properties of β-hematins depend on the synthesis conditions.We greatly acknowledge the financial support from CODI-Universidad de Antioquia through the projects (“ConvocatoriaProgramática 2019-2020: Ciencias Exactas y Naturales”,Project code 2020-33176).Peer reviewedAmerican Chemical SocietyUniversidad de AntioquiaHerrera, Julieth [0000-0001-6799-7616]#NODATA##NODATA#Marco, J.F. [0000-0002-5147-1449]Barrero Meneses, César [0000-0002-4217-1161]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/387206https://api.elsevier.com/content/abstract/scopus_id/105000433558reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésACS omegahttps://doi.org/10.1021/acsomega.4c06694Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3872062026-05-22T06:33:51Z
dc.title.none.fl_str_mv Distinct Physical Properties of β-Hematin in Two Synthetic Media: Compelling Evidence
title Distinct Physical Properties of β-Hematin in Two Synthetic Media: Compelling Evidence
spellingShingle Distinct Physical Properties of β-Hematin in Two Synthetic Media: Compelling Evidence
Herrera, Julieth
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Distinct Physical Properties of β-Hematin in Two Synthetic Media: Compelling Evidence
title_full Distinct Physical Properties of β-Hematin in Two Synthetic Media: Compelling Evidence
title_fullStr Distinct Physical Properties of β-Hematin in Two Synthetic Media: Compelling Evidence
title_full_unstemmed Distinct Physical Properties of β-Hematin in Two Synthetic Media: Compelling Evidence
title_sort Distinct Physical Properties of β-Hematin in Two Synthetic Media: Compelling Evidence
dc.creator.none.fl_str_mv Herrera, Julieth
García, Karen Edilma
Perez, Valentina
Marco, J.F.
Barrero Meneses, César
author Herrera, Julieth
author_facet Herrera, Julieth
García, Karen Edilma
Perez, Valentina
Marco, J.F.
Barrero Meneses, César
author_role author
author2 García, Karen Edilma
Perez, Valentina
Marco, J.F.
Barrero Meneses, César
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Antioquia
Herrera, Julieth [0000-0001-6799-7616]
#NODATA#
#NODATA#
Marco, J.F. [0000-0002-5147-1449]
Barrero Meneses, César [0000-0002-4217-1161]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description 16 pages, 10 figures, 12 tables
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/387206
https://api.elsevier.com/content/abstract/scopus_id/105000433558
url http://hdl.handle.net/10261/387206
https://api.elsevier.com/content/abstract/scopus_id/105000433558
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv ACS omega
https://doi.org/10.1021/acsomega.4c06694
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414032763518976
score 15,81155

Similares en LA Referencia