Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, anxiety, hyperactivity, and interest restricted to specific subjects. In addition to the genetic factors, multiple environmental factors have been related to the deve...

ver descrição completa

Detalhes bibliográficos
Autores: Ricarte, Marina, Tagkalidou, Niki, Bellot, Marina, Bedrossiantz, Juliette, Prats, Eva, Gómez-Canela, Cristian, Garcia-Reyero, Natàlia, Raldúa, Demetrio
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universitat Ramon Llull (URL)
Repositorio:DAU Arxiu Digital de la Universitat Ramon Llull
OAI Identifier:oai:dau.url.edu:20.500.14342/4750
Acesso em linha:http://hdl.handle.net/20.500.14342/4750
https://doi.org/10.3390/ijms25147688
Access Level:acceso abierto
Palavra-chave:valproic acid
animal model
zebrafish
autism spectrum disorder
social behavior
neurotransmitter
615
id ES_96cd8467fdf011e7f1d63bf0dbd917d5
oai_identifier_str oai:dau.url.edu:20.500.14342/4750
network_acronym_str ES
network_name_str España
repository_id_str
spelling Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in ZebrafishRicarte, MarinaTagkalidou, NikiBellot, MarinaBedrossiantz, JuliettePrats, EvaGómez-Canela, CristianGarcia-Reyero, NatàliaRaldúa, Demetriovalproic acidanimal modelzebrafishautism spectrum disordersocial behaviorneurotransmitter615Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, anxiety, hyperactivity, and interest restricted to specific subjects. In addition to the genetic factors, multiple environmental factors have been related to the development of ASD. Animal models can serve as crucial tools for understanding the complexity of ASD. In this study, a chemical model of ASD has been developed in zebrafish by exposing embryos to valproic acid (VPA) from 4 to 48 h post-fertilization, rearing them to the adult stage in fish water. For the first time, an integrative approach combining behavioral analysis and neurotransmitters profile has been used for determining the effects of early-life exposure to VPA both in the larval and adult stages. Larvae from VPA-treated embryos showed hyperactivity and decreased visual and vibrational escape responses, as well as an altered neurotransmitters profile, with increased glutamate and decreased acetylcholine and norepinephrine levels. Adults from VPA-treated embryos exhibited impaired social behavior characterized by larger shoal sizes and a decreased interest for their conspecifics. A neurotransmitter analysis revealed a significant decrease in dopamine and GABA levels in the brain. These results support the potential predictive validity of this model for ASD research.info:eu-repo/semantics/publishedVersionMDPIUniversitat Ramon Llull. IQS202520252024info:eu-repo/semantics/article12 p.application/pdfhttp://hdl.handle.net/20.500.14342/4750https://doi.org/10.3390/ijms25147688reponame:DAU Arxiu Digital de la Universitat Ramon Llullinstname:Universitat Ramon Llull (URL)InglésInternational Journal of Molecular Sciences. 2024;25(14):7688info:eu-repo/grantAgreement/MCIN/PN I+D/PID2020-113371RB-C21info:eu-repo/grantAgreement/MCIN/PN I+D/PID2020-113371RB-C21info:eu-repo/grantAgreement/MCIN/PN I+D/TED2021-130845B-C3info:eu-repo/grantAgreement/MCIN i IDAEA-CSIC/PN I+D/CEX2018-000794-Sinfo:eu-repo/grantAgreement/MICIN i FSE/FI/PRE2018-083513© L'autor/aAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dau.url.edu:20.500.14342/47502026-06-21T06:40:37Z
dc.title.none.fl_str_mv Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
spellingShingle Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
Ricarte, Marina
valproic acid
animal model
zebrafish
autism spectrum disorder
social behavior
neurotransmitter
615
title_short Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title_full Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title_fullStr Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title_full_unstemmed Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title_sort Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
dc.creator.none.fl_str_mv Ricarte, Marina
Tagkalidou, Niki
Bellot, Marina
Bedrossiantz, Juliette
Prats, Eva
Gómez-Canela, Cristian
Garcia-Reyero, Natàlia
Raldúa, Demetrio
author Ricarte, Marina
author_facet Ricarte, Marina
Tagkalidou, Niki
Bellot, Marina
Bedrossiantz, Juliette
Prats, Eva
Gómez-Canela, Cristian
Garcia-Reyero, Natàlia
Raldúa, Demetrio
author_role author
author2 Tagkalidou, Niki
Bellot, Marina
Bedrossiantz, Juliette
Prats, Eva
Gómez-Canela, Cristian
Garcia-Reyero, Natàlia
Raldúa, Demetrio
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. IQS
dc.subject.none.fl_str_mv valproic acid
animal model
zebrafish
autism spectrum disorder
social behavior
neurotransmitter
615
topic valproic acid
animal model
zebrafish
autism spectrum disorder
social behavior
neurotransmitter
615
description Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, anxiety, hyperactivity, and interest restricted to specific subjects. In addition to the genetic factors, multiple environmental factors have been related to the development of ASD. Animal models can serve as crucial tools for understanding the complexity of ASD. In this study, a chemical model of ASD has been developed in zebrafish by exposing embryos to valproic acid (VPA) from 4 to 48 h post-fertilization, rearing them to the adult stage in fish water. For the first time, an integrative approach combining behavioral analysis and neurotransmitters profile has been used for determining the effects of early-life exposure to VPA both in the larval and adult stages. Larvae from VPA-treated embryos showed hyperactivity and decreased visual and vibrational escape responses, as well as an altered neurotransmitters profile, with increased glutamate and decreased acetylcholine and norepinephrine levels. Adults from VPA-treated embryos exhibited impaired social behavior characterized by larger shoal sizes and a decreased interest for their conspecifics. A neurotransmitter analysis revealed a significant decrease in dopamine and GABA levels in the brain. These results support the potential predictive validity of this model for ASD research.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/4750
https://doi.org/10.3390/ijms25147688
url http://hdl.handle.net/20.500.14342/4750
https://doi.org/10.3390/ijms25147688
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Sciences. 2024;25(14):7688
info:eu-repo/grantAgreement/MCIN/PN I+D/PID2020-113371RB-C21
info:eu-repo/grantAgreement/MCIN/PN I+D/PID2020-113371RB-C21
info:eu-repo/grantAgreement/MCIN/PN I+D/TED2021-130845B-C3
info:eu-repo/grantAgreement/MCIN i IDAEA-CSIC/PN I+D/CEX2018-000794-S
info:eu-repo/grantAgreement/MICIN i FSE/FI/PRE2018-083513
dc.rights.none.fl_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:DAU Arxiu Digital de la Universitat Ramon Llull
instname:Universitat Ramon Llull (URL)
instname_str Universitat Ramon Llull (URL)
reponame_str DAU Arxiu Digital de la Universitat Ramon Llull
collection DAU Arxiu Digital de la Universitat Ramon Llull
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413979992883200
score 15.812429

Registos relacionados