Correction of hyponatremia may be a treatment stratification biomarker: A two-stage systematic review and meta-analysis

Producción Científica

Detalles Bibliográficos
Autores: Herrera Gómez, Francisco Magno, Monge Donaire, Diana, Ochoa Sangrador, Carlos, Bustamante Munguira, Juan, Alamartine, Eric, Álvarez González, Francisco Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/55918
Acceso en línea:https://doi.org/10.3390/jcm7090262
https://uvadoc.uva.es/handle/10324/55918
Access Level:acceso abierto
Palabra clave:Hyponatremia
Biomarkers
Drug evaluation
Heart failure
Ascites
32 Ciencias Médicas
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spelling Correction of hyponatremia may be a treatment stratification biomarker: A two-stage systematic review and meta-analysisHerrera Gómez, Francisco MagnoMonge Donaire, DianaOchoa Sangrador, CarlosBustamante Munguira, JuanAlamartine, EricÁlvarez González, Francisco JavierHyponatremiaBiomarkersDrug evaluationHeart failureAscites32 Ciencias MédicasProducción CientíficaChanges in serum sodium concentration ([Na+]serum) can permit evaluation of the treatment effect of vasopressin antagonists (vaptans) in patients with worsening heart failure (HF) or cirrhotic ascites; that is, they may act as a treatment stratification biomarker. A two-stage systematic review and meta-analysis were carried out and contextualized by experts in fluid resuscitation and translational pharmacology (registration ID in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42017051440). Meta-analysis of aggregated dichotomous outcomes was performed. Pooled estimates for correction of hyponatremia (normalization or an increase in [Na+]serum of at least 3–5 mEq/L) under treatment with vaptans (Stage 1) and for clinical outcomes in both worsening HF (rehospitalization and/or death) and cirrhotic ascites (ascites worsening) when correction of hyponatremia is achieved (Stage 2) were calculated. The body of evidence was assessed. Correction of hyponatremia was achieved under vaptans (odds ratio (OR)/95% confidence interval (95% CI)/I2/number of studies (n): 7.48/4.95–11.30/58%/15). Clinical outcomes in both worsening HF and cirrhotic ascites improved when correction of hyponatremia was achieved (OR/95% CI/I2/n: 0.51/0.26–0.99/52%/3). Despite the appropriateness of the study design, however, there are too few trials to consider that correction of hyponatremia is a treatment stratification biomarker. Patients with worsening HF or with cirrhotic ascites needing treatment with vaptans, have better clinical outcomes when correction of hyponatremia is achieved. However, the evidence base needs to be enlarged to propose formally correction of hyponatremia as a new treatment stratification biomarker. Markers for use with drugs are needed to improve outcomes related to the use of medicines.Junta de Castilla y León (VA161G18)MDPI2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/jcm7090262https://uvadoc.uva.es/handle/10324/55918reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.mdpi.com/2077-0383/7/9/262info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:uvadoc.uva.es:10324/559182026-06-13T12:44:47Z
dc.title.none.fl_str_mv Correction of hyponatremia may be a treatment stratification biomarker: A two-stage systematic review and meta-analysis
title Correction of hyponatremia may be a treatment stratification biomarker: A two-stage systematic review and meta-analysis
spellingShingle Correction of hyponatremia may be a treatment stratification biomarker: A two-stage systematic review and meta-analysis
Herrera Gómez, Francisco Magno
Hyponatremia
Biomarkers
Drug evaluation
Heart failure
Ascites
32 Ciencias Médicas
title_short Correction of hyponatremia may be a treatment stratification biomarker: A two-stage systematic review and meta-analysis
title_full Correction of hyponatremia may be a treatment stratification biomarker: A two-stage systematic review and meta-analysis
title_fullStr Correction of hyponatremia may be a treatment stratification biomarker: A two-stage systematic review and meta-analysis
title_full_unstemmed Correction of hyponatremia may be a treatment stratification biomarker: A two-stage systematic review and meta-analysis
title_sort Correction of hyponatremia may be a treatment stratification biomarker: A two-stage systematic review and meta-analysis
dc.creator.none.fl_str_mv Herrera Gómez, Francisco Magno
Monge Donaire, Diana
Ochoa Sangrador, Carlos
Bustamante Munguira, Juan
Alamartine, Eric
Álvarez González, Francisco Javier
author Herrera Gómez, Francisco Magno
author_facet Herrera Gómez, Francisco Magno
Monge Donaire, Diana
Ochoa Sangrador, Carlos
Bustamante Munguira, Juan
Alamartine, Eric
Álvarez González, Francisco Javier
author_role author
author2 Monge Donaire, Diana
Ochoa Sangrador, Carlos
Bustamante Munguira, Juan
Alamartine, Eric
Álvarez González, Francisco Javier
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Hyponatremia
Biomarkers
Drug evaluation
Heart failure
Ascites
32 Ciencias Médicas
topic Hyponatremia
Biomarkers
Drug evaluation
Heart failure
Ascites
32 Ciencias Médicas
description Producción Científica
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/jcm7090262
https://uvadoc.uva.es/handle/10324/55918
url https://doi.org/10.3390/jcm7090262
https://uvadoc.uva.es/handle/10324/55918
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/2077-0383/7/9/262
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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