An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies

A new anticancer agent based on the conjugation of a photoactivatable Pt(iv) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing α<inf>V</inf>β<inf>3<...

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Autores: Gandioso, Albert, Shaili, Evyenia, Massaguer i Vall-llovera, Anna, Artigas, Gerard, González-Cantó, Alejandro, Woods, Julie A., Sadler, Evyenia, Marchán, Vicente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/12279
Acceso en línea:http://hdl.handle.net/10256/12279
Access Level:acceso abierto
Palabra clave:Medicaments antineoplàstics
Antineoplastic agents
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spelling An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studiesGandioso, AlbertShaili, EvyeniaMassaguer i Vall-llovera, AnnaArtigas, GerardGonzález-Cantó, AlejandroWoods, Julie A.Sadler, EvyeniaMarchán, VicenteMedicaments antineoplàsticsAntineoplastic agentsA new anticancer agent based on the conjugation of a photoactivatable Pt(iv) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing α<inf>V</inf>β<inf>3</inf> integrin compared to control DU-145 human prostate carcinoma cellsRoyal Society of Chemistry (RSC)2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10256/12279http://hdl.handle.net/10256/12279© Chemical Communications, 2015, vol. 51, p. 9169-9172Articles publicats (D-B)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1039/C5CC03180Jinfo:eu-repo/semantics/altIdentifier/issn/1359-7345info:eu-repo/semantics/altIdentifier/eissn/1364-548XAttribution 3.0 Spainhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/122792026-05-29T05:05:01Z
dc.title.none.fl_str_mv An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies
title An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies
spellingShingle An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies
Gandioso, Albert
Medicaments antineoplàstics
Antineoplastic agents
title_short An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies
title_full An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies
title_fullStr An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies
title_full_unstemmed An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies
title_sort An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies
dc.creator.none.fl_str_mv Gandioso, Albert
Shaili, Evyenia
Massaguer i Vall-llovera, Anna
Artigas, Gerard
González-Cantó, Alejandro
Woods, Julie A.
Sadler, Evyenia
Marchán, Vicente
author Gandioso, Albert
author_facet Gandioso, Albert
Shaili, Evyenia
Massaguer i Vall-llovera, Anna
Artigas, Gerard
González-Cantó, Alejandro
Woods, Julie A.
Sadler, Evyenia
Marchán, Vicente
author_role author
author2 Shaili, Evyenia
Massaguer i Vall-llovera, Anna
Artigas, Gerard
González-Cantó, Alejandro
Woods, Julie A.
Sadler, Evyenia
Marchán, Vicente
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Medicaments antineoplàstics
Antineoplastic agents
topic Medicaments antineoplàstics
Antineoplastic agents
description A new anticancer agent based on the conjugation of a photoactivatable Pt(iv) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing α<inf>V</inf>β<inf>3</inf> integrin compared to control DU-145 human prostate carcinoma cells
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/12279
http://hdl.handle.net/10256/12279
url http://hdl.handle.net/10256/12279
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/C5CC03180J
info:eu-repo/semantics/altIdentifier/issn/1359-7345
info:eu-repo/semantics/altIdentifier/eissn/1364-548X
dc.rights.none.fl_str_mv Attribution 3.0 Spain
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 3.0 Spain
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry (RSC)
publisher.none.fl_str_mv Royal Society of Chemistry (RSC)
dc.source.none.fl_str_mv © Chemical Communications, 2015, vol. 51, p. 9169-9172
Articles publicats (D-B)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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