Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum

Introduction Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the world's population and encompasses a spectrum of liver conditions, from non-alcoholic steatohepatitis (NASH) to inflammation and fibrosis. In addition, NAFLD also links to extrahepatic conditions like diabetes or obe...

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Autores: León-Mengibar, J, Sánchez, E, Herrerías, F, de la Fuente, MC, Santamaría, M, Valdivielso, JM, Bermúdez-López, M, Castro, E, Pallarés, J, Matias-Guiu, X, Vilardell, F, Caixàs, A, Bueno, M, Marti, R, Lecube, A
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p4967
Acesso em linha:https://i3pt.portalinvestigacion.com/publicaciones/4967
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193460456&doi=10.3389%2ffendo.2024.1366015&partnerID=40&md5=fa5ac9fb02391fcc38d90520a26d94f8
Access Level:acceso abierto
Palavra-chave:atherosclerosis
vasa vasorum
vascular disease
nonalcoholic fatty liver disease
obesity
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spelling Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorumLeón-Mengibar, JSánchez, EHerrerías, Fde la Fuente, MCSantamaría, MValdivielso, JMBermúdez-López, MCastro, EPallarés, JMatias-Guiu, XVilardell, FCaixàs, ABueno, MMarti, RLecube, Aatherosclerosisvasa vasorumvascular diseasenonalcoholic fatty liver diseaseobesityIntroduction Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the world's population and encompasses a spectrum of liver conditions, from non-alcoholic steatohepatitis (NASH) to inflammation and fibrosis. In addition, NAFLD also links to extrahepatic conditions like diabetes or obesity. However, it remains unclear if NAFLD independently correlates with the onset and progression of atherosclerosis.Material and methods This cross-sectional study aimed to explore the relationship between NAFLD severity, assessed via liver biopsy, and early atherosclerosis using adventitial vasa vasorum (VV) density. It included 44 patients with obesity (33 with steatosis, 11 with NASH) undergoing bariatric surgery.Results Results revealed no significant differences in adventitial VV density between steatosis and NASH groups, neither in the mean values [0.759 +/- 0.104 vs. 0.780 +/- 0.043, P=0.702] nor left-right sides. Similarly, carotid intima-media thickness (cIMT) did not vary between these groups. Additionally, no linear correlation existed between VV density and cIMT. Only gender showed an association with VV density.Conclusion These findings suggest that NASH severity doesn't independently drive early atherosclerosis or affects cIMT. Gender might play a role in early atherosclerotic disease in NAFLD, impacting VV density and cIMT. This highlights the need to consider other risk factors when evaluating cardiovascular risk in NAFLD patients.FRONTIERS MEDIA SA2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/4967https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193460456&doi=10.3389%2ffendo.2024.1366015&partnerID=40&md5=fa5ac9fb02391fcc38d90520a26d94f8Frontiers in EndocrinologyISSN: 16642392reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p49672026-06-21T15:30:37Z
dc.title.none.fl_str_mv Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
title Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
spellingShingle Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
León-Mengibar, J
atherosclerosis
vasa vasorum
vascular disease
nonalcoholic fatty liver disease
obesity
title_short Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
title_full Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
title_fullStr Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
title_full_unstemmed Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
title_sort Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
dc.creator.none.fl_str_mv León-Mengibar, J
Sánchez, E
Herrerías, F
de la Fuente, MC
Santamaría, M
Valdivielso, JM
Bermúdez-López, M
Castro, E
Pallarés, J
Matias-Guiu, X
Vilardell, F
Caixàs, A
Bueno, M
Marti, R
Lecube, A
author León-Mengibar, J
author_facet León-Mengibar, J
Sánchez, E
Herrerías, F
de la Fuente, MC
Santamaría, M
Valdivielso, JM
Bermúdez-López, M
Castro, E
Pallarés, J
Matias-Guiu, X
Vilardell, F
Caixàs, A
Bueno, M
Marti, R
Lecube, A
author_role author
author2 Sánchez, E
Herrerías, F
de la Fuente, MC
Santamaría, M
Valdivielso, JM
Bermúdez-López, M
Castro, E
Pallarés, J
Matias-Guiu, X
Vilardell, F
Caixàs, A
Bueno, M
Marti, R
Lecube, A
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv atherosclerosis
vasa vasorum
vascular disease
nonalcoholic fatty liver disease
obesity
topic atherosclerosis
vasa vasorum
vascular disease
nonalcoholic fatty liver disease
obesity
description Introduction Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the world's population and encompasses a spectrum of liver conditions, from non-alcoholic steatohepatitis (NASH) to inflammation and fibrosis. In addition, NAFLD also links to extrahepatic conditions like diabetes or obesity. However, it remains unclear if NAFLD independently correlates with the onset and progression of atherosclerosis.Material and methods This cross-sectional study aimed to explore the relationship between NAFLD severity, assessed via liver biopsy, and early atherosclerosis using adventitial vasa vasorum (VV) density. It included 44 patients with obesity (33 with steatosis, 11 with NASH) undergoing bariatric surgery.Results Results revealed no significant differences in adventitial VV density between steatosis and NASH groups, neither in the mean values [0.759 +/- 0.104 vs. 0.780 +/- 0.043, P=0.702] nor left-right sides. Similarly, carotid intima-media thickness (cIMT) did not vary between these groups. Additionally, no linear correlation existed between VV density and cIMT. Only gender showed an association with VV density.Conclusion These findings suggest that NASH severity doesn't independently drive early atherosclerosis or affects cIMT. Gender might play a role in early atherosclerotic disease in NAFLD, impacting VV density and cIMT. This highlights the need to consider other risk factors when evaluating cardiovascular risk in NAFLD patients.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/4967
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193460456&doi=10.3389%2ffendo.2024.1366015&partnerID=40&md5=fa5ac9fb02391fcc38d90520a26d94f8
url https://i3pt.portalinvestigacion.com/publicaciones/4967
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193460456&doi=10.3389%2ffendo.2024.1366015&partnerID=40&md5=fa5ac9fb02391fcc38d90520a26d94f8
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Endocrinology
ISSN: 16642392
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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