Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humans
Microtubules are intracellular filaments that define in space and in time a large number of essential cellular functions such as cell division, morphology and motility, intracellular transport and flagella and cilia assembly. They are therefore essential for spermatozoon and oocyte maturation and fu...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/42194 |
| Acceso en línea: | http://hdl.handle.net/10230/42194 http://dx.doi.org/10.1093/biolre/ioy203 |
| Access Level: | acceso abierto |
| Palabra clave: | Early embryo development Oocytes Spermatozoa Tubulin Tubulin isotypes tubulin post-translational modifications (PTMs) |
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Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humansAmargant i Riera, Farners, 1990-Barragan, MontserratVassena, RitaVernos, Isabelle, 1959-Early embryo developmentOocytesSpermatozoaTubulinTubulin isotypestubulin post-translational modifications (PTMs)Microtubules are intracellular filaments that define in space and in time a large number of essential cellular functions such as cell division, morphology and motility, intracellular transport and flagella and cilia assembly. They are therefore essential for spermatozoon and oocyte maturation and function, and for embryo development. The dynamic and functional properties of the microtubules are in large part defined by various classes of interacting proteins including MAPs (microtubule associated proteins), microtubule-dependent motors, and severing and modifying enzymes. Multiple mechanisms regulate these interactions. One of them is defined by the high diversity of the microtubules themselves generated by the combination of different tubulin isotypes and by several tubulin post-translational modifications (PTMs). This generates a so-called tubulin code that finely regulates the specific set of proteins that associates with a given microtubule thereby defining the properties and functions of the network. Here we provide an in depth review of the current knowledge on the tubulin isotypes and PTMs in spermatozoa, oocytes, and preimplantation embryos in various model systems and in the human species. We focus on functional implications of the tubulin code for cytoskeletal function, particularly in the field of human reproduction and development, with special emphasis on gamete quality and infertility. Finally, we discuss some of the knowledge gaps and propose future research directions.Oxford University Press20192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/42194http://dx.doi.org/10.1093/biolre/ioy203reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésBiol Reprod. 2019; 100(3):575-589© Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in Biology of reproduction following peer review. The version of record Amargant F, Barragan M, Vassena R, Vernos I. Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humans. Biol Reprod. 2019; 100(3):575-589 is available online at: http://dx.doi.org/10.1093/biolre/ioy203info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/421942026-06-12T07:21:37Z |
| dc.title.none.fl_str_mv |
Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humans |
| title |
Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humans |
| spellingShingle |
Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humans Amargant i Riera, Farners, 1990- Early embryo development Oocytes Spermatozoa Tubulin Tubulin isotypes tubulin post-translational modifications (PTMs) |
| title_short |
Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humans |
| title_full |
Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humans |
| title_fullStr |
Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humans |
| title_full_unstemmed |
Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humans |
| title_sort |
Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humans |
| dc.creator.none.fl_str_mv |
Amargant i Riera, Farners, 1990- Barragan, Montserrat Vassena, Rita Vernos, Isabelle, 1959- |
| author |
Amargant i Riera, Farners, 1990- |
| author_facet |
Amargant i Riera, Farners, 1990- Barragan, Montserrat Vassena, Rita Vernos, Isabelle, 1959- |
| author_role |
author |
| author2 |
Barragan, Montserrat Vassena, Rita Vernos, Isabelle, 1959- |
| author2_role |
author author author |
| dc.subject.none.fl_str_mv |
Early embryo development Oocytes Spermatozoa Tubulin Tubulin isotypes tubulin post-translational modifications (PTMs) |
| topic |
Early embryo development Oocytes Spermatozoa Tubulin Tubulin isotypes tubulin post-translational modifications (PTMs) |
| description |
Microtubules are intracellular filaments that define in space and in time a large number of essential cellular functions such as cell division, morphology and motility, intracellular transport and flagella and cilia assembly. They are therefore essential for spermatozoon and oocyte maturation and function, and for embryo development. The dynamic and functional properties of the microtubules are in large part defined by various classes of interacting proteins including MAPs (microtubule associated proteins), microtubule-dependent motors, and severing and modifying enzymes. Multiple mechanisms regulate these interactions. One of them is defined by the high diversity of the microtubules themselves generated by the combination of different tubulin isotypes and by several tubulin post-translational modifications (PTMs). This generates a so-called tubulin code that finely regulates the specific set of proteins that associates with a given microtubule thereby defining the properties and functions of the network. Here we provide an in depth review of the current knowledge on the tubulin isotypes and PTMs in spermatozoa, oocytes, and preimplantation embryos in various model systems and in the human species. We focus on functional implications of the tubulin code for cytoskeletal function, particularly in the field of human reproduction and development, with special emphasis on gamete quality and infertility. Finally, we discuss some of the knowledge gaps and propose future research directions. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/42194 http://dx.doi.org/10.1093/biolre/ioy203 |
| url |
http://hdl.handle.net/10230/42194 http://dx.doi.org/10.1093/biolre/ioy203 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Biol Reprod. 2019; 100(3):575-589 |
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info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Oxford University Press |
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Oxford University Press |
| dc.source.none.fl_str_mv |
reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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Repositorio Digital de la UPF |
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Repositorio Digital de la UPF |
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