Assessment of lifetime exposure to trihalomethanes through different routes

5 pages, 1 figure, 2 tables.-- PMID: 16556748 [PubMed].

Detalles Bibliográficos
Autores: Villanueva, Cristina M., Cantor, Kenneth P., Grimalt, Joan O., Castaño-Vinyals, Gemma, Malats, Núria, Silverman, Debra, Tardón, Adonina, Garcia-Closas, Reina, Serra, C., Carrato, Alfredo, Rothman, Nathaniel, Real, Francisco X., Dosemeci, Mustafa, Kogevinas, Manolis
Tipo de recurso: artículo
Fecha de publicación:2006
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/12100
Acceso en línea:http://hdl.handle.net/10261/12100
Access Level:acceso abierto
Palabra clave:Disinfection by‐products
Trihalomethanes
Exposure assessment
Exposure routes
Case‐control study
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spelling Assessment of lifetime exposure to trihalomethanes through different routesVillanueva, Cristina M.Cantor, Kenneth P.Grimalt, Joan O.Castaño-Vinyals, GemmaMalats, NúriaSilverman, DebraTardón, AdoninaGarcia-Closas, ReinaSerra, C.Carrato, AlfredoRothman, NathanielReal, Francisco X.Dosemeci, MustafaKogevinas, ManolisDisinfection by‐productsTrihalomethanesExposure assessmentExposure routesCase‐control study5 pages, 1 figure, 2 tables.-- PMID: 16556748 [PubMed].[Objetives] To evaluate lifetime exposure to trihalomethanes (THM) through ingestion, inhalation, and dermal absorption in a hospital based case‐control study of bladder cancer conducted between 1998 and 2001 in five areas of Spain. The study base was comprised of subjects living in the catchment areas of the participating hospitals.[Methods] Individual information on water related habits was obtained from personal interviews of 1219 cases and 1271 controls: residential and occupational history, drinking water source at each residence and job, amount of water consumption, frequency and duration of showering, bathing, and swimming pool attendance. THM levels, water source history, and year when chlorination started in study areas were ascertained through measurements in drinking water samples and questionnaires to water companies and local authorities. Estimates of THM levels covered 79% of the subjects' person‐years of exposure.[Result] Current and historical average THM levels in water were correlated. Control subjects reported that drinking water source in the last residence was municipal for 63%, bottled for 22%, private well for 2%, and other sources for 13%. For the time window between age 15 and the time of interview, average residential THM level was 32.2 μg/l. THM exposure through ingestion was 23.7 μg/day on average, and was correlated with the ingestion THM level in the workplace. Overall, 79% usually took showers, 16% usually took baths, and 13% had ever attended a swimming pool. Between 21% and 45% of controls unexposed to THM through ingestion were evaluated as moderately or highly exposed through showering or bathing, and 5–10% were exposed through swimming in pools.[Conclusion] The importance of evaluating different routes is underscored by findings from experimental studies showing substantial differences in THM uptake and internal distribution by route.This project was funded by the Spanish Ministry of Health (FIS 2001–2002), the EPICUR-red (ISIII-GO3/174), the Intramural Research Program of the NIH, National Cancer Institute, Division of Cancer Epidemiology and Genetics (NCI Contract No. NO2-CP-11015), and the European Union (Environment and genetic factors in bladder cancer: a multicentric case-control study in Europe. BIOMED. 1998–2001).Peer reviewedBMJ Publishing Group200920092006info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_650119968 bytesapplication/mswordhttp://hdl.handle.net/10261/12100reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1136/oem.2005.023069info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/121002026-05-22T06:33:51Z
dc.title.none.fl_str_mv Assessment of lifetime exposure to trihalomethanes through different routes
title Assessment of lifetime exposure to trihalomethanes through different routes
spellingShingle Assessment of lifetime exposure to trihalomethanes through different routes
Villanueva, Cristina M.
Disinfection by‐products
Trihalomethanes
Exposure assessment
Exposure routes
Case‐control study
title_short Assessment of lifetime exposure to trihalomethanes through different routes
title_full Assessment of lifetime exposure to trihalomethanes through different routes
title_fullStr Assessment of lifetime exposure to trihalomethanes through different routes
title_full_unstemmed Assessment of lifetime exposure to trihalomethanes through different routes
title_sort Assessment of lifetime exposure to trihalomethanes through different routes
dc.creator.none.fl_str_mv Villanueva, Cristina M.
Cantor, Kenneth P.
Grimalt, Joan O.
Castaño-Vinyals, Gemma
Malats, Núria
Silverman, Debra
Tardón, Adonina
Garcia-Closas, Reina
Serra, C.
Carrato, Alfredo
Rothman, Nathaniel
Real, Francisco X.
Dosemeci, Mustafa
Kogevinas, Manolis
author Villanueva, Cristina M.
author_facet Villanueva, Cristina M.
Cantor, Kenneth P.
Grimalt, Joan O.
Castaño-Vinyals, Gemma
Malats, Núria
Silverman, Debra
Tardón, Adonina
Garcia-Closas, Reina
Serra, C.
Carrato, Alfredo
Rothman, Nathaniel
Real, Francisco X.
Dosemeci, Mustafa
Kogevinas, Manolis
author_role author
author2 Cantor, Kenneth P.
Grimalt, Joan O.
Castaño-Vinyals, Gemma
Malats, Núria
Silverman, Debra
Tardón, Adonina
Garcia-Closas, Reina
Serra, C.
Carrato, Alfredo
Rothman, Nathaniel
Real, Francisco X.
Dosemeci, Mustafa
Kogevinas, Manolis
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Disinfection by‐products
Trihalomethanes
Exposure assessment
Exposure routes
Case‐control study
topic Disinfection by‐products
Trihalomethanes
Exposure assessment
Exposure routes
Case‐control study
description 5 pages, 1 figure, 2 tables.-- PMID: 16556748 [PubMed].
publishDate 2006
dc.date.none.fl_str_mv 2006
2009
2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/12100
url http://hdl.handle.net/10261/12100
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1136/oem.2005.023069
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 19968 bytes
application/msword
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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