Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex
To investigate the importance of time in pregnancy and neonatal sex on the association between maternal metabolic parameters and neonatal sum of skinfolds. This was a longitudinal, secondary analysis of the vitamin D and lifestyle intervention for gestational diabetes mellitus study, conducted in ni...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:283892 |
| Acceso en línea: | https://ddd.uab.cat/record/283892 https://dx.doi.org/urn:doi:10.1111/ijpo.12628 |
| Access Level: | acceso abierto |
| Palabra clave: | Foetal growth Foetal programming Maternal health Metabolic syndrome Neonatal body composition Pregnancy |
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Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sexSecondary analysis of the DALI studyLima, Rodrigo|||0000-0002-7778-2616Desoye, Gernot|||0000-0002-5715-3230Simmons, David|||0000-0003-0560-0761Devlieger, Roland|||0000-0001-7837-4684Galjaard, Sander|||0000-0002-4254-6664Corcoy i Pla, Rosa|||0000-0001-5055-6814Adelantado, Juan M.|||0000-0001-6399-4856Dunne, Fidelma|||0000-0003-3682-9403Harreiter, Jürgen|||0000-0003-2508-9403Kautzky-Willer, Alexandra|||0000-0002-3520-4105Damm, Peter|||0000-0002-2067-5246Mathiesen, Elisabeth Reinhardt|||0000-0003-3279-0863Jensen, Dorte M.|||0000-0002-3298-9824Andersen, Lise-Lotte|||0000-0003-2997-2228Tanvig, MetteLapolla, AnnunziataDalfra, Maria Grazia|||0000-0002-3011-0521Bertolotto, Alessandra|||0000-0003-1578-5421Wender-Ozegowska, Ewa|||0000-0002-5492-8651Zawiejska, Agnieszka|||0000-0002-3616-6550Hill, D.J.Snoek, F. J.Jelsma, Judith G. M.|||0000-0001-7943-9160Van Poppel, Mireille|||0000-0001-5694-4324Foetal growthFoetal programmingMaternal healthMetabolic syndromeNeonatal body compositionPregnancyTo investigate the importance of time in pregnancy and neonatal sex on the association between maternal metabolic parameters and neonatal sum of skinfolds. This was a longitudinal, secondary analysis of the vitamin D and lifestyle intervention for gestational diabetes mellitus study, conducted in nine European countries during 2012 to 2015. Pregnant women with a pre-pregnancy body mass index (BMI) of ≥29 kg/m were invited to participate. We measured 14 maternal metabolic parameters at three times during pregnancy: <20 weeks, 24 to 28 weeks, and 35 to 37 weeks of gestation. The sum of four skinfolds assessed within 2 days after birth was the measure of neonatal adiposity. In total, 458 mother-infant pairs (50.2% female infants) were included. Insulin resistance (fasting insulin and HOMA-index of insulin resistance) in early pregnancy was an important predictor for boys' sum of skinfolds, in addition to fasting glucose and maternal adiposity (leptin, BMI and neck circumference) throughout pregnancy. In girls, maternal lipids (triglycerides and fatty acids) in the first half of pregnancy were important predictors of sum of skinfolds, as well as fasting glucose in the second half of pregnancy. Associations between maternal metabolic parameters and neonatal adiposity vary between different periods during pregnancy. This time-dependency is different between sexes, suggesting different growth strategies.Universitat Autònoma de Barcelona 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/283892https://dx.doi.org/urn:doi:10.1111/ijpo.12628reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2838922026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex Secondary analysis of the DALI study |
| title |
Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex |
| spellingShingle |
Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex Lima, Rodrigo|||0000-0002-7778-2616 Foetal growth Foetal programming Maternal health Metabolic syndrome Neonatal body composition Pregnancy |
| title_short |
Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex |
| title_full |
Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex |
| title_fullStr |
Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex |
| title_full_unstemmed |
Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex |
| title_sort |
Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex |
| dc.creator.none.fl_str_mv |
Lima, Rodrigo|||0000-0002-7778-2616 Desoye, Gernot|||0000-0002-5715-3230 Simmons, David|||0000-0003-0560-0761 Devlieger, Roland|||0000-0001-7837-4684 Galjaard, Sander|||0000-0002-4254-6664 Corcoy i Pla, Rosa|||0000-0001-5055-6814 Adelantado, Juan M.|||0000-0001-6399-4856 Dunne, Fidelma|||0000-0003-3682-9403 Harreiter, Jürgen|||0000-0003-2508-9403 Kautzky-Willer, Alexandra|||0000-0002-3520-4105 Damm, Peter|||0000-0002-2067-5246 Mathiesen, Elisabeth Reinhardt|||0000-0003-3279-0863 Jensen, Dorte M.|||0000-0002-3298-9824 Andersen, Lise-Lotte|||0000-0003-2997-2228 Tanvig, Mette Lapolla, Annunziata Dalfra, Maria Grazia|||0000-0002-3011-0521 Bertolotto, Alessandra|||0000-0003-1578-5421 Wender-Ozegowska, Ewa|||0000-0002-5492-8651 Zawiejska, Agnieszka|||0000-0002-3616-6550 Hill, D.J. Snoek, F. J. Jelsma, Judith G. M.|||0000-0001-7943-9160 Van Poppel, Mireille|||0000-0001-5694-4324 |
| author |
Lima, Rodrigo|||0000-0002-7778-2616 |
| author_facet |
Lima, Rodrigo|||0000-0002-7778-2616 Desoye, Gernot|||0000-0002-5715-3230 Simmons, David|||0000-0003-0560-0761 Devlieger, Roland|||0000-0001-7837-4684 Galjaard, Sander|||0000-0002-4254-6664 Corcoy i Pla, Rosa|||0000-0001-5055-6814 Adelantado, Juan M.|||0000-0001-6399-4856 Dunne, Fidelma|||0000-0003-3682-9403 Harreiter, Jürgen|||0000-0003-2508-9403 Kautzky-Willer, Alexandra|||0000-0002-3520-4105 Damm, Peter|||0000-0002-2067-5246 Mathiesen, Elisabeth Reinhardt|||0000-0003-3279-0863 Jensen, Dorte M.|||0000-0002-3298-9824 Andersen, Lise-Lotte|||0000-0003-2997-2228 Tanvig, Mette Lapolla, Annunziata Dalfra, Maria Grazia|||0000-0002-3011-0521 Bertolotto, Alessandra|||0000-0003-1578-5421 Wender-Ozegowska, Ewa|||0000-0002-5492-8651 Zawiejska, Agnieszka|||0000-0002-3616-6550 Hill, D.J. Snoek, F. J. Jelsma, Judith G. M.|||0000-0001-7943-9160 Van Poppel, Mireille|||0000-0001-5694-4324 |
| author_role |
author |
| author2 |
Desoye, Gernot|||0000-0002-5715-3230 Simmons, David|||0000-0003-0560-0761 Devlieger, Roland|||0000-0001-7837-4684 Galjaard, Sander|||0000-0002-4254-6664 Corcoy i Pla, Rosa|||0000-0001-5055-6814 Adelantado, Juan M.|||0000-0001-6399-4856 Dunne, Fidelma|||0000-0003-3682-9403 Harreiter, Jürgen|||0000-0003-2508-9403 Kautzky-Willer, Alexandra|||0000-0002-3520-4105 Damm, Peter|||0000-0002-2067-5246 Mathiesen, Elisabeth Reinhardt|||0000-0003-3279-0863 Jensen, Dorte M.|||0000-0002-3298-9824 Andersen, Lise-Lotte|||0000-0003-2997-2228 Tanvig, Mette Lapolla, Annunziata Dalfra, Maria Grazia|||0000-0002-3011-0521 Bertolotto, Alessandra|||0000-0003-1578-5421 Wender-Ozegowska, Ewa|||0000-0002-5492-8651 Zawiejska, Agnieszka|||0000-0002-3616-6550 Hill, D.J. Snoek, F. J. Jelsma, Judith G. M.|||0000-0001-7943-9160 Van Poppel, Mireille|||0000-0001-5694-4324 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Foetal growth Foetal programming Maternal health Metabolic syndrome Neonatal body composition Pregnancy |
| topic |
Foetal growth Foetal programming Maternal health Metabolic syndrome Neonatal body composition Pregnancy |
| description |
To investigate the importance of time in pregnancy and neonatal sex on the association between maternal metabolic parameters and neonatal sum of skinfolds. This was a longitudinal, secondary analysis of the vitamin D and lifestyle intervention for gestational diabetes mellitus study, conducted in nine European countries during 2012 to 2015. Pregnant women with a pre-pregnancy body mass index (BMI) of ≥29 kg/m were invited to participate. We measured 14 maternal metabolic parameters at three times during pregnancy: <20 weeks, 24 to 28 weeks, and 35 to 37 weeks of gestation. The sum of four skinfolds assessed within 2 days after birth was the measure of neonatal adiposity. In total, 458 mother-infant pairs (50.2% female infants) were included. Insulin resistance (fasting insulin and HOMA-index of insulin resistance) in early pregnancy was an important predictor for boys' sum of skinfolds, in addition to fasting glucose and maternal adiposity (leptin, BMI and neck circumference) throughout pregnancy. In girls, maternal lipids (triglycerides and fatty acids) in the first half of pregnancy were important predictors of sum of skinfolds, as well as fasting glucose in the second half of pregnancy. Associations between maternal metabolic parameters and neonatal adiposity vary between different periods during pregnancy. This time-dependency is different between sexes, suggesting different growth strategies. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2 2020-01-01 2020 2020-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/283892 https://dx.doi.org/urn:doi:10.1111/ijpo.12628 |
| url |
https://ddd.uab.cat/record/283892 https://dx.doi.org/urn:doi:10.1111/ijpo.12628 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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